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Probing the mechanism of ADAM28-mediated cancer metastasis
Date:6/8/2012

ration and spontaneous metastasis to distant organs."

In an accompanying editorial, Stanley Zucker, M.D. and Jian Cao, M.D., of the Department of Medicine at Veterans Affairs Medical Center in Northport, New York, write that the study opens the door to many other questions regarding the metastatic process. For example, they write, "An association of VWF levels in blood and tissues and ADAM28 levels in patients' tumor tissue with indolent versus aggressive cancers would be revealing." They also point out that the fact that mouse lung metastases occur within weeks, but human metastases over years is cause for concern.

The researchers also pose the question of whether a small number of driver genes will be identified in the metastatic process, or individual human tumors will require different proteins to complete the metastatic process. They write, "We have the cell and molecular technology, animal models, and clinical tools to solve the problem, but the path to drug discovery for treatment of metastasis and the dream of turning cancer into a "chronic disease" might turn the dream into an obstacle."


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Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

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