Navigation Links
Probing the mechanism of ADAM28-mediated cancer metastasis
Date:6/8/2012

ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute.

Several ADAMs are known to be found in tumors and are linked with both tumor growth and cancer progression in humans. While ADAM28 is overexpressed in both breast and non-small cell lung cancers, the mechanism of ADAM28-mediated metastasis is unknown.

In order to search for substrates of ADAM28, Satsuki Mochizuki, Ph.D., of the Department of Pathology at the School of Medicine at Keio University in Japan, and colleagues screened a human lung cDNA library for ADAM28-binding proteins by a yeast two-hybrid system, and identified VWF as a candidate. ADAM28's effect on VWF-induced apoptosis was measured in various human cancer cell lines, while the effect of its inhibition on lung metastases of human lung cancer and breast cancer cells was investigated in mouse models.

The researchers found that inhibition of ADAM28 expression or activity showed a substantial reduction in lung metastases and increased apoptosis of cancer cells in blood vessels. "Our data in this study have demonstrated that VWF induces apoptosis in many human cell lines established from carcinomas of the lung, breast, kidney, and liver only when they have very low-level expression of ADAM28 or when the activity and/or expression are knocked down," the researchers write. The researchers note the limitations of the study, however, namely that the model doesn't reflect the spontaneous metastatic process of human cancers that involves invading carcinoma cells from the primary tumors during a long period of time. Still they feel that, "the results suggest that ADAM28 has dual promoting effects on carcinoma cell prolife
'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study supports urate protection against Parkinsons disease, hints at novel mechanism
2. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
3. Researchers gain better understanding of mechanism behind tau spreading in the brain
4. Joslin scientists identify important mechanism that affects the aging process
5. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
6. Study sheds new light on role of genetic mutations in colon cancer development
7. Child CT Scans Might Up Risk of Brain Cancer, Leukemia
8. 2-1-1 could be effective tool in fighting cancer disparities
9. Researchers at IRB Barcelona uncover new clues about the origin of cancer
10. Nanomedicines promise fewer side effects in treating cancer
11. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... quality in health care and,universal care., WASHINGTON, ... the German Embassy:, Quote, With the ... health care coverage for all remains one of ... on individual citizens, employers,insurance companies, and state and ...
... Siemens Provides Advanced Clinical and Information Technology That, Optimizes Cardiology ... ... Efficiency, SEATTLE, May 16 /PRNewswire/ -. ... healthcare market, Siemens Healthcare, (http://www.siemens.com/healthcare ) will demonstrate the syngo(R) Suite ...
... Campaign to Visit Detroit to Rally Residents to Eat Right, Move More and ... ... be defined by the,ups and downs of different fad diets -- which seem ... success has been,slim. Two out of three Americans -- including 30 percent of ...
... 16 Less than a week after,committing medical ... by,Cyclone Nargis, Project HOPE, an international health education ... this time to meet the urgent medical needs ... massive earthquake, which has claimed over,20,000 lives., ...
... than in people who didn,t have cancer as children, study ... had cancer as children or teens are more likely to ... the heart problems surface at a much earlier age than ... Childhood cancer survivors "have approximately a five to 10 times ...
... Texas M. D. Anderson Cancer Center have discovered a ... their energy source and hastening cell starvation. , In ... the Children,s Cancer Hospital at M. D. Anderson, found ... inhibitor, rapamycin, induced more than 90 percent cell death ...
Cached Medicine News:Health News:The German Embassy Would Like to Draw Your Attention to the Press Release of the University of Minnesota Center for German & European Studies to Present Major Healthcare Forum 2Health News:Siemens Healthcare Showcases Its Portfolio of Image Management Solutions at SIIM 2008 2Health News:Siemens Healthcare Showcases Its Portfolio of Image Management Solutions at SIIM 2008 3Health News:Siemens Healthcare Showcases Its Portfolio of Image Management Solutions at SIIM 2008 4Health News:Siemens Healthcare Showcases Its Portfolio of Image Management Solutions at SIIM 2008 5Health News:Message to Michigan Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Michigan Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Project HOPE to Send Humanitarian Assistance to China as Humanitarian Assistance to Myanmar Continues 2Health News:Childhood Cancer Survivors Prone to Early Heart Trouble 2Health News:Childhood Cancer Survivors Prone to Early Heart Trouble 3Health News:New drug combination brings 1-2 punch against acute leukemia 2
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014 /PRNewswire/ ... (NASDAQ: ENDP ) (TSX: ENL), and BioDelivery ... today that they have submitted a New Drug Application ... Food and Drug Administration (FDA).  Buprenorphine HCl Buccal Film ... enough to require daily, around-the-clock, long-term opioid treatment and ...
(Date:12/22/2014)... Apnea Sciences ( www.apneasciences.com ) announced it ... Aliso Viejo , California.  Jimmy Fallon , ... and worldwide expansion, a new facility with expanded infrastructure ... snore cure have exceeded our expectations and thus required ... in 23 countries and will be increasing to 39 ...
(Date:12/22/2014)... LUXEMBOURG , Dec. 22, 2014  ConvaTec, a ... Paul Moraviec has been appointed Interim Chief Executive Officer ... Mr. Moraviec succeeds Ken Berger .  "The Board ... service in leading ConvaTec over the past three years," ... Board of Directors.  "We are confident that the company ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... As previously disclosed, Sun Pharmaceutical Industries, Ltd. And Sun ... Caraco Pharmaceutical Laboratories, Ltd. (NYSE Amex: CPD ) ... by which Sun Pharma would acquire all of the outstanding ... for a per share consideration of $4.75 cash. At a ...
... 7, 2010 The Foundation for the National Institutes ... of a proteomics study performed utilizing plasma samples from ... be shared with scientists worldwide for further analysis.   ... the Biomarkers Consortium Project Use of Targeted Multiplex ...
Cached Medicine Technology:Independent Committee of Caraco Board to Consider Sun Pharma Proposal to Purchase Outstanding Shares 2Independent Committee of Caraco Board to Consider Sun Pharma Proposal to Purchase Outstanding Shares 3The Biomarkers Consortium Announces Availability of Alzheimer's Disease Plasma Proteomics Data 2The Biomarkers Consortium Announces Availability of Alzheimer's Disease Plasma Proteomics Data 3The Biomarkers Consortium Announces Availability of Alzheimer's Disease Plasma Proteomics Data 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: