forward in this prize should attract the attention of those with the resources necessary to move a potentially effective ALS therapy into the clinic," said Dr. Tom Maniatis, Chair of the Biochemistry & Molecular Biophysics Program at Columbia University, a prominent ALS researcher and member of Prize4Life's Scientific Advisory Board. "The Kremer prize will only be awarded for a therapy that makes a major difference in the disease, the kinds of therapies that ALS patients really need."
Prize4Life was the first disease-oriented organization to utilize the incentive prize model to address neurodegenerative disease. "There are challenges to this model, to be sure," noted Dr. Maniatis, "but if Prize4Life succeeds, the payoff could be huge. This effort could have major implications not just for ALS patients, but for any group looking to bring new ideas to the table for solving a biomedical problem."
After its first year, the Treatment Prize has attracted teams from industry and academia from across the globe. Competing teams are pursuing several therapeutic approaches, including cell-based therapies to replace damaged cells and the use of protein biologics, and small molecule drugs to interfere with pathways implicated in disease progression (see website for more information).
Says Treatment Prize competitor Michal Schwartz, professor at the Weizmann Institute of Science: "We believe that the approach that we have pioneered is promising, a paradigm shift. By exposing our approach to the community, we are hoping that additional scientists will be inspired." Schwartz's lab has identified a severe immune deficit and immunosuppression in ALS patients and mouse models, and is seeking ways to rejuvenate or arrest immune malfunction.
In support of its Treatment Prize competitors, Prize4Life has partnered with the Jackson Laboratory to provide quality-controlled SOD1 mice for preclinical drug testing. They have also prepared Page: 1 2 3 Related medicine news :1
. Prize4Life and the Alzheimer Research Forum Announce Launch of New Web-Portal for ALS Research2
. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top3
. Middle School Marks Most Critical Time to Start Ongoing Conversations About Drug and Alcohol Use With Kids4
. Excerpts from DNC Chairman Howard Deans Remarks at the National Baptist Convention5
. End-to-End HR Performance Benchmarks: Metrics That Will Help Turn the HR Cost Center into a Productivity Driver6
. Health Department Marks Take a Loved One to the Doctor Day7
. Skin Cooling After Laser Treatment Could Leave Marks8
. Grand Opening of Regence Boys & Girls Club Marks a Milestone in Historic New Columbia Community Revitalization9
. Presidents Veto of Childrens Health Bill Marks First Round in National Fight About Health Care10
. 600 Smiles Restored Thanks to the AACDCFs Give Back A Smile Program - October Marks National Domestic Violence Awareness Month11
. Test for Life Marks National Latino AIDS Awareness Day, Announces Launch of Florida Coalition