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Prism Pharmaceuticals Receives FDA Approval of NEXTERONE(R) for Life-Threatening Ventricular Fibrillation and Ventricular Tachycardia
Date:1/5/2009

lished in September 2006, provides Prism with non-dilutive capital to enable the company to bring NEXTERONE through the period of NDA review and commercial launch.

Dr. Cooper will present the corporate strategy for PRISM Pharmaceuticals, the commercial plans for NEXTERONE and the product pipeline at the 27th Annual JP Morgan Healthcare Conference on January 13, 2009 at 7:30 a.m. PST/10:30 a.m. EST. A webcast of the presentation will be available on http://www.prismpharma.com.

About Ventricular Fibrillation and Ventricular Tachycardia

Ventricular fibrillation is a condition in which the heart's electrical activity becomes disordered. When this happens, the heart's lower (pumping) chambers contract in a rapid, unsynchronized way. (The ventricles "flutter" rather than beat.) The heart pumps little or no blood. Ventricular fibrillation is very serious. Collapse and sudden cardiac death will follow in minutes unless medical help is provided immediately.

Ventricular tachycardia is a fast or rapid heart rate that starts in the heart's lower chambers (ventricles). Ventricular tachycardia may result from serious heart disease and usually requires prompt treatment.

Important Safety Information About NEXTERONE

The most important treatment-emergent adverse effects associated with intravenous amiodarone therapy in clinical studies were hypotension, asystole/cardiac arrest/electromechanical dissociation (EMD), cardiogenic shock, congestive heart failure, bradycardia, liver function test abnormalities, ventricular tachycardia, and atrioventricular block. Overall, treatment was discontinued for about 9 percent of the patients because of adverse effects. The most common adverse effects leading to discontinuation of intravenous amiodarone therapy were hypotension (1.6 percent), asystole/cardiac arrest/EMD (1.2 percent)
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