Navigation Links
Prions in the brain eliminated by homing molecules
Date:4/24/2012

Toxic prions in the brain can be detected with self-illuminating polymers. The originators, at Linkping University in Sweden, has now shown that the same molecules can also render the prions harmless, and potentially cure fatal nerve-destroying illnesses.

Linkping researchers and their colleagues at the University Hospital in Zrich tested the luminescent conjugated polymers, or LCPs, on tissue sections from the brains of mice that had been infected with prions. The results show that the number of prions, as well as their toxicity and infectibility, decreased drastically. This is the first time anyone has been able to demonstrate the possibility of treating illnesses such as mad cow disease and Creutzfeldt-Jacobs with LCP molecules.

"When we see this effect on prion infections, we believe the same approach could work on Alzheimer's disease as well," says Peter Nilsson, researcher in Bioorganic Chemistry funded by ERC, the European Research Council.

Along with professors Per Hammarstrm and Adriano Aguzzi and others, he is now publishing the results in The Journal of Biological Chemistry.

Prions are diseased forms of normally occurring proteins in the brain. When they clump together in large aggregates, nerve cells in the surrounding area are affected, which leads to serious brain damage and a quick death. Prion illnesses can be inherited, occur spontaneously or through infection, for example through infected meat as was the case with mad cow disease.

The course of the illness is relentless when the prions fall to pieces and replicate at an exponential rate. When researchers inserted the LCP molecules into their model system, the replication was arrested, possible through stabilizing the prion aggregates.

The variable components in an LCP are various chemical subgroups attached onto the polymer. In the published study, eight different substances were tested, and all of them had significant effect on the toxicity of the prions.

"Based on these results, we can now customise entirely new molecules with potentially even better effect. These are now being tested on animal models," Nilsson says.

Researchers want to go even further and test whether the molecules will function on fruit flies with an Alzheimer's-like nerve disorder. Alzheimer's is caused by what is known as amyloid plaque, which has a similar but slower course than prion diseases.


'/>"/>
Contact: Peter Nilsson
peter.r.nilsson@liu.se
46-132-82787
Linkping University
Source:Eurekalert

Related medicine news :

1. How the brains daily clock controls mood: A new project
2. Strength Training May Give Boost to Seniors Brains
3. Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
4. Gatekeeper of brain steroid signals boosts emotional resilience to stress
5. Brain surgery for epilepsy underutilized
6. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
7. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
8. Men More Prone to Complications After Brain, Spine Surgery
9. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
10. Anxiety Linked to Smarts in Brain Study
11. Brain Changes May Hamper Decision-Making in Old Age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... ... "Success Files," a short- and long-form documentary style show ... estimated to affect the lives of more than 5 million Americans living with ... voice in the fight for cure and research into the disease, its causes, ...
(Date:9/22/2017)... ... 2017 , ... “Fruit of the Spirit: “Love””: a delightful adventure of ... created. “Fruit of the Spirit: “Love”” is the creation of published author, Halimah Jones, ... of five. Halimah is an avid writer, her inspiration for “Fruit of the Spirit: ...
(Date:9/22/2017)... Diego, CA (PRWEB) , ... September 22, 2017 ... ... offer groceries, wearable, and more products at customers’ doorstep. According to Smart Mart, ... Smart Mart has stated to offer wearable, and customers can find clothing at ...
(Date:9/22/2017)... Greenwich, Connecticut (PRWEB) , ... September 22, 2017 ... ... to conquering Lyme and other tick-borne diseases through research, education and awareness, today ... , A noted immunologist and microbiologist, Dr. Sellati has more than 20 ...
(Date:9/21/2017)... FL (PRWEB) , ... September 21, 2017 , ... 38-Year-Old ... Aesthetic Surgery Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet ... Top 40 Under 40 is an annual award that was started in ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... INDIANAPOLIS , Sept. 9, 2017  Eli Lilly ... key primary and secondary endpoint data for lasmiditan, an ... migraine, which demonstrated statistically significant improvements compared to placebo ... be highlighted today at the 18th Congress of the ... . "The data presented today demonstrate lasmiditan,s ...
(Date:9/7/2017)... , Sept. 7, 2017 NuvoAir (formerly ... Spirometer, announced today a partnership with Novartis Pharma AG to ... NuvoAir,s position as the leading mobile spirometry platform and Novartis, ... ... ...
(Date:9/6/2017)...  Medical professionals are expected to continuously ... their patients. Medical simulations offer clinicians the ... Simulation provides a safe method for teaching ... refine techniques and build confidence, without putting ... such as augmented reality, will now provide ...
Breaking Medicine Technology: