Navigation Links
Prions and cancer: A story unfolding
Date:6/25/2012

Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and Alzheimer's. Once misfolded, a protein can no longer exert its normal functions in the cell.

Now, a group led by Dr Jerson Lima Silva at the Federal University of Rio de Janeiro, Brazil, presents some new evidence that p53, a protein with the daunting task of suppressing tumor formation in the body, may show a typical prion-like behavior when mutated.

It has been known for some time that the buildup of p53 in the cell impairs the protein in preventing tumor growth. This has been observed in neuroblastoma, retinoblastoma, breast, and colon cancers. In a paper entitled "Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: Implications for cancer" and published in the Journal of Biological Chemistry, the group shows that in breast cancer cell lines carrying the most common p53 mutation, the formation of amyloid-like aggregates of p53 proteins may explain the protein's lack of function.

Whether this prionoid behavior in fact represents a relevant cancer-related mechanism remains to be shown. Development of novel and ingenious strategies to prevent p53 misfolding and aggregation may be just one way to find out.

"We are planning pre-clinical tests with synthesized nucleic acids in an attempt to prevent the changing in conformation of normal p53, and avoid aggregates of misfolded protein," says Dr. Silva.

If successful, the strategy may help unveil unforeseen molecular mechanisms leading to tumor development. Considering that more than half of the cancers lose p53 function, this prionoid behavior may serve as a potential novel target for cancer therapy, dramatically transforming our way of thinking of cancer and treating cancer patients.


'/>"/>

Contact: Jerson Lima Silva
jerson@bioqmed.ufrj.br
55-212-562-6756
55-21-8596-5962
Publicase Comunicao Cientfica


Source:Eurekalert

Related medicine news :

1. Prions in the brain eliminated by homing molecules
2. Multiple sclerosis patients have lower risk of cancer: UBC-VCH research
3. New Drug Effective for Rare Genetic Skin Cancer: Studies
4. Common Painkillers May Help Prevent Skin Cancer: Study
5. Many Young Adults at Risk of Skin Cancer: CDC
6. Surgery Rates Rising for Non-Melanoma Skin Cancer: Study
7. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
8. You Survived Cancer: Now Pay Attention to Your Overall Health
9. Seattle Physician Shares Health IT Story in the Nation’s Capital
10. Fitness Fights High Blood Pressure, Even With Family History
11. Are women with a history of violent experiences more likely to have risky sex?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... 05, 2016 , ... The 2016 Nike Soccer Camp will be directed by ... coaching staff. Together they bring their winning Vandals coaching philosophy to young athletes. Programs ... 5-13, and high school players. Session dates are as follows: , Youth Day Camp ...
(Date:5/5/2016)... ... 2016 , ... Talent Tech Labs (TTL) is pleased to announce ... National Nurses Week (May 6-12). Currently, HireNurses is a job listing and matching ... Talent Tech Lab Virtual Incubation program, they will dramatically expand the functionality and ease ...
(Date:5/5/2016)... Toledo, Ohio (PRWEB) , ... May 05, 2016 , ... ... Revenue Cycle. , Clark brings more than 15 years of experience within the ... comes from a successful career as the Director of Patient Financial Services at Spectrum ...
(Date:5/5/2016)... , ... May 05, 2016 , ... The Lung Institute will celebrate its ... a seminar at most clinic locations throughout the month of May. To date, the Lung ... “The rapid growth that we’ve seen is a testament to the success of this treatment ...
(Date:5/5/2016)... ... May 05, 2016 , ... T.E.N., a technology and ... May 3, at the 2016 ISE® Central Executive Forum and Awards Gala at ... Chief Security Officer of HMS, was selected as the Information Security Executive® of ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... May 5, 2016 ... addition of the  "Europe Thrombocythemia Market ...  report to their offering.  ... , ,The latest research Europe Thrombocythemia ... 2016, provides comprehensive insights into Thrombocythemia ...
(Date:5/4/2016)... York , May 4, 2016 ... Transparency Market Research entitled "Brain Computer Interface Market - Global ... - 2024," the  global brain computer interface (BCI) market  is ... 2024. The market is estimated to expand at a ... 2016 to 2024. A BCI device provides ...
(Date:5/4/2016)... , May 4, 2016 ... concluded a series of free workshops across ... global requirements for Good Distribution Practices (GDP). ... which ensures that products are consistently stored, transported and ... authorization (MA) or product specification. Only a few years ...
Breaking Medicine Technology: