Navigation Links
Prion-like proteins drive several diseases of aging
Date:9/5/2013

Two leading neurology researchers have proposed a theory that could unify scientists' thinking about several neurodegenerative diseases and suggest therapeutic strategies to combat them.

The theory and backing for it are described in Nature.

Mathias Jucker and Lary Walker outline the emerging concept that many of the brain diseases associated with aging, such as Alzheimer's and Parkinson's, are caused by specific proteins that misfold and aggregate into harmful seeds.

These seeds behave very much like the pathogenic agents known as prions, which cause mad cow disease, chronic wasting disease in deer, scrapie in sheep, and Creutzfeldt-Jakob disease in humans.

Walker is research professor at Yerkes National Primate Research Center, Emory University. Jucker is head of the Department of Cellular Neurology at the Hertie Institute for Clinical Brain Research at the University of Tbingen and the German Center for Neurodegenerative Diseases.

Unlike prion diseases, which can be infectious, Alzheimer's, Parkinson's, and other neurodegenerative diseases can not be passed from person to person under normal circumstances. Once all of these diseases take hold in the brain, however, it is increasingly apparent that the clumps of misfolded proteins spread throughout the nervous system and disrupt its function.

The authors were the first to show that a protein that is involved in Alzheimer's disease -- known as amyloid-beta -- forms prion-like seeds that stimulate the aggregation of other amyloid-beta molecules in senile plaques and in brain blood vessels. Since then, a growing number of laboratories worldwide have discovered that proteins linked to other neurodegenerative disorders also share key features with prions.

Age-related neurodegenerative disorders remain stubbornly resistant to the discovery of effective treatments. Jucker and Walker propose that the concept of pathogenic protein seeding not only
'/>"/>

Contact: Lisa Newbern
lisa.newbern@emory.edu
404-727-7709
Emory Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New screening approach identifies small proteins unique to melanoma cells, Moffitt researcher says
2. New Alzheimers research suggests possible cause: The interaction of proteins in the brain
3. Proteins in migration
4. Preclinical tests shows agent stops slippery proteins from binding, causing Ewing sarcoma
5. Resurrection of 3-billion-year-old antibiotic-resistance proteins
6. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
7. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
8. Pair of proteins gets brain cells into shape
9. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
10. G proteins regulate remodelling of blood vessels
11. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Utah (PRWEB) September 23, 2014 ... and corporate training, will be attending and exhibiting ... the American Health Information Management Association (AHIMA) in ... September 27 through October 1, and Career Step ... on its suite of coding training products, including ...
(Date:9/22/2014)... (PRWEB) September 23, 2014 The Marietta ... helping to promote National Breast Cancer Awareness Month ... contribute awareness to cause, prevention, diagnosis, treatment and cure by ... offices across the U.S. , A pink edition Philips ... that can tell us why the Sonicare is important to ...
(Date:9/22/2014)... During the annual Oregon Health Care Association ... care and senior housing industry are recognized for their ... of others. , This year, Nicolette Merino, Regional ... awarded the OHCA Special Service Award. This award is ... assist OHCA in reaching strategic objectives or help achieve ...
(Date:9/22/2014)... York, NY (PRWEB) September 22, 2014 On ... Radio Network launched their first evening show, “KC After Dark.” ... Marcus Edwards, “KC After Dark” will air every Tuesday at ... a free iPad for the 50th caller, and because of ... well past the call in mark with 500 callers. ...
(Date:9/22/2014)... Sterling Heights, MI (PRWEB) September 22, 2014 ... will be partnering with Playworks, a local nonprofit that is ... At least 50 volunteers including UHY employees, their families and ... Americas School to help paint on cement games and graphics, ... , This outing was originally scheduled to occur in ...
Breaking Medicine News(10 mins):Health News:Career Step to Exhibit at AHIMA Convention September 27 through October 1 2Health News:Verde Pointe Dental Associates Participate in Breast Cancer Awareness Month 2014 with a Pink Philips Sonicare Giveaway 2Health News:Avamere Family of Companies Regional Director Nominated for the Oregon Health Care Association 2014 Special Service Award 2Health News:The Women’s Radio Network, WRNW1’s First Evening Show a Huge Success 2Health News:Local CPA Firm Gears Up To Revamp Detroit Elementary School Playground 2Health News:Local CPA Firm Gears Up To Revamp Detroit Elementary School Playground 3
... Neuroradiologist in the Mayo clinic said that after the treatment ... ,He says that the treatment is very effective when compared ... ,He also explains that vertebroplasty is a process in ... compression fractures are present. These compressions arise due to osteoporosis. ...
... worst AIDS affected countries in the world, with an infection ... all // those who were in need of it. The ... to 110,000 people. The country is badly in need of ... entire nation will be destroyed socially and economically. ...
... might be using "substandard poultry vaccine", which could be the ... flu //in that country. ,Dr Robert Webster, ... that this problem was not confined to mainland China alone. ... vaccines. I think there are substandard vaccines for influenza in ...
... woman in Gopinathpur village after she underwent a family planning ... panic and confusion in the Kendrapara district. // ... been operated (tubectomy) as a part of the health camp, ... husband, Sudarshan, Jayanti had complaints of severe abdominal pain after ...
... validated from Medicare data as Medicare covers more than 40 ... be known from these data // reports Professor Richard Platt, ... useful for knowing the true benefits of the drug and ... the data obtained from Medicare would be far better than ...
... molecular link between the type 2 diabetes onset and ... fat. // This is because of the disruption in ... according to a recent research. According to the researchers, ... glycosyltransferase (GnT-4a) disrupts insulin production. ,The experiments ...
Cached Medicine News:Health News:Improved cure and activity level seen among patients treated by Vertebroplasty. 2Health News:Botswana Continues Its Fight Against AIDS 2
(Date:9/22/2014)... 2014 ... eTMF im Jahr 2015 verdoppeln werden ... klinischen Versuchsreihen, die zunehmenden Anforderungen der Gesundheitsbehörden ... mit Informationen über ihre Versuchsreihen (Trial Master ... Die bisher größte TMF-Umfrage in der ...
(Date:9/22/2014)... 22, 2014 Levi & Korsinsky is investigating ... "the Company") (NasdaqGS: SIAL ) for possible ... law in connection with the sale of the Company ... to learn more about the investigation: http://zlkdocs.com/SIAL-Info-Request-Form_ma-2199 , ... to you. Under the terms of the ...
(Date:9/22/2014)... Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR ... $200 million of its common stock in an underwritten ... Merrill Lynch are acting as joint book-running managers for ... option to purchase additional shares of its common stock. ... offering are being sold by Avanir.  The offering is ...
Breaking Medicine Technology:Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 2Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 3Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 4Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 5SIGMA-ALDRICH INVESTOR ALERT: Levi & Korsinsky, LLP Investigates the Board of Directors of Sigma-Aldrich Corporation In Connection with the Sale of the Company to Merck -- SIAL 2Avanir Pharmaceuticals Announces Proposed Public Offering of Common Stock 2Avanir Pharmaceuticals Announces Proposed Public Offering of Common Stock 3
... MELVILLE, N.Y., Nov. 28, 2011  Henry Schein, Inc. ... of health care products and services to office-based ... Complete™ program, a new integrated comprehensive solution that ... for the successful implementation of dental sleep medicine ...
... Medical Incorporated (OTCBB: ONCS), a biotechnology company developing ... cancer and other solid tumor cancers, today announced ... presenting at the 15th Annual Biotech and Specialty ... (Logo: http://photos.prnewswire.com/prnh/20110314/MM64943LOGO ) ...
Cached Medicine Technology:Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 2Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 3Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 4Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 5OncoSec to Present at 15th Annual Biotech and Specialty Pharmaceuticals Conference 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: