Navigation Links
Princeton scientists break cholera's lines of communication
Date:11/14/2007

ests.

The team found that when CAI-1 is absent, cholera bacteria act as pathogens. But when the bacteria detect enough of this chemical, they stop making biofilms and releasing toxins, perceiving that it is time to leave the body instead.

"Our findings demonstrate that if you supply CAI-1 to cholera, you can flip their switches to stop the attack," Higgins said.

Chemist Helen Blackwell of the University of Wisconsin-Madison praised the study, calling it a breakthrough for quorum sensing research, and possibly for medical science.

"Lots of other bugs like staph, strep and E. coli use the same general type of signaling mechanism as cholera," said Blackwell, an assistant professor of chemistry. "Many people are looking for ways to inhibit the signaling process, and you could imagine using this process to turn off cholera. It suggests a direct pathway into the clinic."

The field is still far from possessing a complete dictionary of the bacterial chemical lexicon, Bassler said, and this lexicon must be better understood before clinical applications can be developed. But the findings are encouraging.

"We have to show that CAI-1 can cure cholera in lab mice," she said. "We'd also like to understand the chemistry of how the molecule is made in the cell. Meanwhile, the best cure for cholera is to provide the world with clean water."


'/>"/>

Contact: Chad Boutin
cboutin@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota ... it means to “Live Fearless.” , The “Faces ... their stories about how they or someone they know has ... living in the moment. By telling these types of stories ...
(Date:1/22/2015)... January 22, 2015 Juvent Sports ( ... the 2015 PGA Merchandise Show to bestow a Juvent ... female amateur golfer, Arlene McKitrick. The award commemorated and ... golf tournament win. She won her first amateur tournament ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Joan Lunden, ... keynote speaker at the upcoming 32nd Annual Miami ... Physicians’ Education Resource®, LLC (PER®) , shares that ... have gone undetected if she had not followed up ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy ... its highest annual revenues in the past three years. Today, ... wedding dresses. , According to the sales manager of the ... for them in 2015. This point can be reflected on ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... WHAT: In March 2007, YouthAIDS Global Ambassador, acclaimed actress ... with Bollywood stars Sushmita ... explore how HIV travels from high-risk groups to the general ... at risk for infection. ...
... In the Peanuts comic strip, Charlie Brown was never able ... a baseball team. He was also sad and often the ... looking at the connections between athletic skill and social acceptance ... life: kids place a great deal of value on athletic ...
... ever-changing U.S. consumer who enjoys the convenience of ready-to-eat produce ... new challenges to food import safety, experts said Oct. 18. ... $2 trillion this year and expected to triple by 2015, ... at Texas A&M University to discuss ways to strengthen the ...
... cobalt-60 supply for the ... healthcare industry, OTTAWA, ... and radiopharmaceuticals, signed a 17-year,contract for the supply of cobalt-60 with ... upon the,2005 agreement by providing for an increased supply of cobalt-60 ...
... - 6th Consecutive Year in Deloitte,s Technology Fast 50 ... Medical Systems,Inc. (Nasdaq: CASM ), a medical device ... that it has been named,to Deloitte,s prestigious Technology Fast ... growing technology, media, telecommunications,and life sciences companies in the ...
... FARMS, Mich., Oct. 19 United,Physicians, P.C., ... Southeast Michigan, has been recertified by the ... Management. NCQA is an independent,non-profit organization that ... provider organizations., "We are proud that ...
Cached Medicine News:Health News:National Geographic Channel, Ashley Judd and YouthAIDS Host World Premiere Screening of 'India's Hidden Plague' 2Health News:The politics of the playground: lack of athletic skill often means loneliness and peer rejection 2Health News:Consumer demand flavors food import safety issues 2Health News:MDS Nordion signs 17-year contract with Rosenergoatom 2Health News:CAS Medical Systems, Inc. Ranked Among Connecticut's Fastest Growing Technology Companies 2Health News:CAS Medical Systems, Inc. Ranked Among Connecticut's Fastest Growing Technology Companies 3Health News:CAS Medical Systems, Inc. Ranked Among Connecticut's Fastest Growing Technology Companies 4Health News:UP Repeats NCQA Certification in Utilization Management 2
(Date:1/23/2015)... 23, 2015  Today the U.S. Food and Drug Administration ... prevention of serogroup B meningococcal disease in ... Trumenba®, which received FDA approval in October, represent a ... "I have heard over and over ...
(Date:1/23/2015)... Jan. 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released ... care leaders and a new study analyzing the impact of increased ... a nationwide coalition working to educate policy makers and the public ... Capitol was focused on how the Iowa ...
(Date:1/23/2015)... ATLANTA , Jan. 23, 2015 More than a ... a quarter of those with private insurance, filled a prescription ... to a report in this week,s Morbidity and Mortality Weekly ... health care providers to treat moderate to severe pain.  They ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... symptomsSAN FRANCISCO, March 17 In a study published ... found that a brain fitness program measured initially for ... had a significant beneficial impact on symptoms of depression. ... older Americans funded by the National Institutes of Health ...
... 16 Healthpoint today announced that it has initiated ... HP802-247 in venous leg ulcers. HP802-247 is a topical ... designed to determine the effectiveness of two cell concentrations ... standard care, compared to placebo plus standard care, in ...
Cached Medicine Technology:Unexpected Side Effect: Makes You Happier 2Unexpected Side Effect: Makes You Happier 3Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers 2Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers 3
... Provides quick freezing and ... of gas system - cleans ... automatically. Lightweight probe tips have ... Cataract, Retinal Detachment, Glaucoma and ...
Khosla Precision and Quality in Medical and Surgical Products....
Khosla Precision and Quality in Medical and Surgical Products....
Manual Table For Slit Lamp...
Medicine Products: