Navigation Links
Princess Margaret breast cancer research finds new drug target companion prognostic test for hormone therapy resistance
Date:4/1/2013

(TORONTO, Canada April 1, 2013) A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target creates hope for a new therapy.

The findings, published online today in PNAS, the Proceedings of the National Academy of Sciences of the United States of America, "provide a new therapeutic target against hormone therapy-resistant breast cancers and a companion test to identify tumours that would become resistant" says Dr. Lupien, a scientist at the Ontario Cancer Institute, the research arm of the cancer centre, and an Assistant Professor in the Department of Medial Biophysics, University of Toronto. He specializes in epigenetics of hormone-dependent cancers the study of non-genetic determinants of cellular identity that can also be altered to initiate or modify disease.

"In studying the epigenetics of hormone therapy resistance, we discovered that breast cancer cells behave like a chameleon. Indeed, as the chameleon changes its skin colour to camouflage itself and evade predators," says Dr. Lupien, "breast cancer cells change the appearance of their DNA through epigenetics to evade, in this case, hormone therapy." In so doing, hormone therapy-resistant breast cancer cells highlight regions of their DNA related to the Notch pathway.

At the molecular level, the research team characterized the epigenetic appearances of the DNA of drug-resistant and drug-responsive breast cancer cells. The team discovered that the Notch signaling pathway plays the predominant role in drug-resistant breast cancer cells even if cells remain positive for ER.

"This is a highly promising discovery that could rapidly translate in the clinic. Drugs against the Notch pathway are available." says Dr. Lupien. The key will be to test the efficacy of these drugs against hormone therapy resistance in breast cancer.


'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert

Related medicine news :

1. HRH Crown Princess Mary of Denmark announced as patron of Australian and Danish twin registries
2. Blue Deer Center in Margaretville, New York, Welcomes Theodore Finkle as New Center Manager
3. Plant Spirit Medicine Healer Training Begins March 2013 at Blue Deer Center in Margaretville, NY
4. ASH honors Margaret A. Goodell, Ph.D., with 2012 William Dameshek Prize
5. More Evidence Shows Hormone Therapy May Increase Breast Cancer Risk
6. When Breast Cancer Spreads to Lungs, Surgery May Increase Survival
7. Estrogen plus progestin use linked with increased breast cancer incidence and mortality
8. Author of new breast cancer study comments on its findings of increased risk
9. University of Maryland breast cancer research pioneer Dr. Angela Brodie named AACR Academy Fellow
10. Associated Plastic Surgeons & Consultants Reports that Insurance Denied Payment for Bilateral Breast Reconstruction Following Mastectomy
11. Newly Release Video Reveals Technical aspects of Advanced Breast Augmentation Surgery The Cold-Subfascial Breast Augmentation TM
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... ... “Nana Nana Boo Boo”: a delightful tale of a young girl who learns ... is the creation of published author Michael Rush, a Deputy Sheriff, former world champion ... new book presents the importance of manners in a way easily understood by children ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... ... of the Connecticut Community for Addiction Recovery (CCAR) will host a second Multiple ... take place in Punta Gorda, Florida. The conference, born from CCAR’s foundational principle ...
(Date:7/23/2017)... ... July 23, 2017 , ... A 20-year-long study by a national ... the Minneapolis Veterans Administration Health Care System overwhelmingly supports growing evidence that prostate cancer ... benefits. , In the cases involved with this study, surgery did not prolong ...
(Date:7/23/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 23, 2017 , ... ... as a way to gain that elusive college scholarship or even go on to ... Sports Medicine’s Annual Meeting in Toronto, Canada today say “not so fast.” ...
(Date:7/23/2017)... ... July 23, 2017 , ... ... Florida Pain Relief Group – Melbourne, a practice owned by Physician Partners of ... interventional pain management, Dr. Stern also is certified in pediatrics, emergency medicine and ...
Breaking Medicine News(10 mins):
(Date:7/6/2017)... , July 6, 2017 ThriveRx, the nutrition division of Diplomat ... families to thrive on nutrition support. To celebrate its anniversary, ... site has a fresh new look with improved organization to create the ... ... "We,ve ...
(Date:7/5/2017)... Pace Analytical, a company of over 2,000 employees and a leader in environmental ... Sciences, further solidifying their position as the top American owned and operated environmental ... ... Analytical ... Mt Juliet, TN , enhances Pace Analytical,s capability as an innovative full ...
(Date:6/30/2017)... , June 30, 2017 In vitro ... the start of May, at least ten diagnostic companies ... private investments, public offerings and a loan facility.  The ... to almost $80 million.  Kalorama Information provides a monthly ... its Diagnostics Knowledge Center. ...
Breaking Medicine Technology: