Navigation Links
Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
Date:1/26/2011

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer.

The findings, published online today in Science Translational Medicine (http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3001922) are significant because they suggest that targeting UROD identified for the first time as a key player in human cancers can selectively boost the effects of radiotherapy and chemotherapy in head and neck tumors, while minimizing toxicity to normal tissues.

"Our analysis of patient biopsies revealed that UROD levels were significantly higher in tumor tissues versus normal tissues. Cancer patients with lower UROD levels prior to radiation treatment had improved clinical outcome, suggesting that UROD could potentially be used to predict patients' response to radiation therapy," says principal investigator, Dr. Fei-Fei Liu, Professor of Radiation Oncology at the University of Toronto and PMH, and Senior Scientist at the Ontario Cancer Institute and The Campbell Family Cancer Research Institute.

Lead author Dr. Emma Ito adds: "This means that lower doses of radiation and chemotherapeutic drugs could potentially be administered to patients without affecting treatment efficacy."

"Despite the advances over the last few decades, the toxic side effects associated with current therapies for head and neck cancer have caused disappointing outcomes in many patients," says Dr. Ito. Head and neck tumors are often found near critical structures, so destroying the diseased tissue is often a delicate challenge that can lead to life-threatening conditions.

"UROD is an enzyme involved in the production of a molecule called heme, which is vital to all body organs. Targeting UROD creates an opportunity to exploit the heme synthesis pathway, which disrupts the equilibrium of iron and free radical levels in cells which in turn kills cancer cells." says Dr. Liu.


'/>"/>

Contact: Sommer Ellis
sommer.ellis@uhn.on.ca
416-340-4011
University Health Network
Source:Eurekalert

Related medicine news :

1. Princess Haya Calls for Action to Protect Health in the Developing World
2. Brand New Princess Cut Diamond Tennis Bracelet To Become Anjolee's Best Selling Product of 2010
3. Cancer genetics pioneer wins Margaret Kripke Legend Award
4. The private sale of drugs in public hospitals
5. Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007
6. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
7. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
8. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
9. American Heart Association Comment on Hospitalization of President Bill Clinton
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. SHARECOR Partners With Quantros, Inc. to Facilitate Core Measures and Regulatory Reporting in Louisiana Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: