Navigation Links
Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
Date:1/26/2011

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer.

The findings, published online today in Science Translational Medicine (http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3001922) are significant because they suggest that targeting UROD identified for the first time as a key player in human cancers can selectively boost the effects of radiotherapy and chemotherapy in head and neck tumors, while minimizing toxicity to normal tissues.

"Our analysis of patient biopsies revealed that UROD levels were significantly higher in tumor tissues versus normal tissues. Cancer patients with lower UROD levels prior to radiation treatment had improved clinical outcome, suggesting that UROD could potentially be used to predict patients' response to radiation therapy," says principal investigator, Dr. Fei-Fei Liu, Professor of Radiation Oncology at the University of Toronto and PMH, and Senior Scientist at the Ontario Cancer Institute and The Campbell Family Cancer Research Institute.

Lead author Dr. Emma Ito adds: "This means that lower doses of radiation and chemotherapeutic drugs could potentially be administered to patients without affecting treatment efficacy."

"Despite the advances over the last few decades, the toxic side effects associated with current therapies for head and neck cancer have caused disappointing outcomes in many patients," says Dr. Ito. Head and neck tumors are often found near critical structures, so destroying the diseased tissue is often a delicate challenge that can lead to life-threatening conditions.

"UROD is an enzyme involved in the production of a molecule called heme, which is vital to all body organs. Targeting UROD creates an opportunity to exploit the heme synthesis pathway, which disrupts the equilibrium of iron and free radical levels in cells which in turn kills cancer cells." says Dr. Liu.


'/>"/>

Contact: Sommer Ellis
sommer.ellis@uhn.on.ca
416-340-4011
University Health Network
Source:Eurekalert

Related medicine news :

1. Princess Haya Calls for Action to Protect Health in the Developing World
2. Brand New Princess Cut Diamond Tennis Bracelet To Become Anjolee's Best Selling Product of 2010
3. Cancer genetics pioneer wins Margaret Kripke Legend Award
4. The private sale of drugs in public hospitals
5. Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007
6. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
7. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
8. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
9. American Heart Association Comment on Hospitalization of President Bill Clinton
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. SHARECOR Partners With Quantros, Inc. to Facilitate Core Measures and Regulatory Reporting in Louisiana Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
Breaking Medicine Technology: