Navigation Links
Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
Date:1/26/2011

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer.

The findings, published online today in Science Translational Medicine (http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3001922) are significant because they suggest that targeting UROD identified for the first time as a key player in human cancers can selectively boost the effects of radiotherapy and chemotherapy in head and neck tumors, while minimizing toxicity to normal tissues.

"Our analysis of patient biopsies revealed that UROD levels were significantly higher in tumor tissues versus normal tissues. Cancer patients with lower UROD levels prior to radiation treatment had improved clinical outcome, suggesting that UROD could potentially be used to predict patients' response to radiation therapy," says principal investigator, Dr. Fei-Fei Liu, Professor of Radiation Oncology at the University of Toronto and PMH, and Senior Scientist at the Ontario Cancer Institute and The Campbell Family Cancer Research Institute.

Lead author Dr. Emma Ito adds: "This means that lower doses of radiation and chemotherapeutic drugs could potentially be administered to patients without affecting treatment efficacy."

"Despite the advances over the last few decades, the toxic side effects associated with current therapies for head and neck cancer have caused disappointing outcomes in many patients," says Dr. Ito. Head and neck tumors are often found near critical structures, so destroying the diseased tissue is often a delicate challenge that can lead to life-threatening conditions.

"UROD is an enzyme involved in the production of a molecule called heme, which is vital to all body organs. Targeting UROD creates an opportunity to exploit the heme synthesis pathway, which disrupts the equilibrium of iron and free radical levels in cells which in turn kills cancer cells." says Dr. Liu.


'/>"/>

Contact: Sommer Ellis
sommer.ellis@uhn.on.ca
416-340-4011
University Health Network
Source:Eurekalert

Related medicine news :

1. Princess Haya Calls for Action to Protect Health in the Developing World
2. Brand New Princess Cut Diamond Tennis Bracelet To Become Anjolee's Best Selling Product of 2010
3. Cancer genetics pioneer wins Margaret Kripke Legend Award
4. The private sale of drugs in public hospitals
5. Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007
6. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
7. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
8. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
9. American Heart Association Comment on Hospitalization of President Bill Clinton
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. SHARECOR Partners With Quantros, Inc. to Facilitate Core Measures and Regulatory Reporting in Louisiana Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in ... in honor of the city’s history as home to some of the world’s leading ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
Breaking Medicine Technology: