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Primary biliary cirrhosis more severe in African-American and Hispanic patients
Date:9/5/2007

res, the authors report. Minority patients reported more limitation of activity, more severe itching and more serious complications such as ascites, hepatic encephalopathy and variceal bleeding. Results from the laboratory tests confirmed the disparity in disease severity. Mostly as a result of their poorer health conditions, a significantly smaller proportion of non-Caucasian patients were enrolled in the trialjust 23.2 percent compared to 53.5 percent of Caucasians.

The reasons for the health disparities are unknown, since patients in both groups were of similar age and had the disease for similar lengths of time. It is not clear whether these patients have more rapid disease, less access to care early in their disease, misdiagnoses due to inadequate testing, absence of liver biopsies or presence of comorbidities which may have lead to delay in treatment, the authors report.

To begin to address the disparity, they suggest, primary biliary cirrhosis should be considered as the diagnosis in cholestatic liver disease in all ethnic populations.

While the disease does predominantly affect Caucasian women, this study revealed a significant number of racial minority patients, and disturbing evidence of inexplicably more advanced disease.


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Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

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