Navigation Links
Primary Tumors Fuel Growth of Cancer Cells
Date:6/12/2008

Finding suggests interception of this signal may thwart metastases, study says

THURSDAY, June 12 (HealthDay News) -- Primary tumors can fuel the growth of stray cancer cells elsewhere in the body, say researchers at the Massachusetts Institute of Technology.

In experiments with mice, the MIT team found that primary tumors derived from human breast cancers seem to promote the growth of distant cancers by mobilizing bone marrow cells, which then feed the growth of the secondary tumors.

The secretion of a substance called osteopontin by the primary tumor is an important part of this process, said the researchers, who noted that osteopontin is present at elevated levels in women with metastatic breast cancer.

While the researchers found that the primary tumor somehow disturbs the make-up of bone marrow, they don't know exactly how that occurs. They also know that osteopontin does not act alone in this process.

The findings, published in the June 13 issue of Cell, may lead to new cancer treatments.

"If metastases depend on stimulation by primary tumors, interception of the signal through neutralizing antibodies," may prevent the spread of cancer, researcher Robert Weinberg said in a prepared statement. "That's still speculative, but it's an interesting idea to ponder."

He noted that current treatments don't specifically target metastases, which causes the vast majority of cancer deaths.

The findings may also prove important for the pre-clinical study of cancers.

"The ability of instigating tumors to foster the growth of a human colon tumor surgical specimen underscores the power of systemic instigation," Weinberg and colleagues wrote. "Indeed, to our knowledge, methods to expedite the growth of human tumor surgical specimens in vivo have not been previously described. These results suggest that the presently described procedure can be used to study aspects of human tumor biology that would otherwise be difficult if not impossible to study."

More information

The National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: Cell Press, news release, June 12, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Primary snoring in children impacts cardiovascular functioning
2. Primary care visits reduce hospital utilization among Medicare beneficiaries at the end of life
3. Aflac to be Primary Sponsor of Carl Edwards and the No. 99 Ford Fusion
4. Can pathological techniques help identify primary colorectal signet ring cell carcinoma?
5. ACP says major system reforms needed to improve the state of primary care medicine in the US
6. Patient Centered Primary Care Collaborative Releases New Guidelines for Health Care Purchasers
7. Providence Saint Joseph Medical Named LA Countys Third Primary Stroke Center
8. Cardinal Health, ClearCount Medical Solutions Sign Primary Distribution Agreement for RFID-Enabled Sponge Counting, Detection System
9. One-Third of U.S. Primary Care Physicians and Cardiologists Do Not Currently Prescribe Treatment to Meet HDL Cholesterol Targets as Recommended By National Guidelines
10. ‘15by2015’ - A Campaign to Strengthen Primary Healthcare Around the World
11. An efficient response in primary care would reduce the use of hospitals by elderly people
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... CA (PRWEB) , ... February 24, 2017 , ... ... for qualifying into the Senior International Elite division on February 12th. Ms. ... Around divisions at the elite qualifier competition held in Las Vegas, Nevada. Frida ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... Department of Justice jointly issued a letter to withdraw previous guidance ... with their gender identity. The guidance issued in May 2016 by the Obama ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease Report®, ... be participating in Rare Disease Day events, hosted by the Rare Disease Legislative ... Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews with ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... Hamlin Dental ... announce that they are sponsoring a raffle. Throughout the month of February, patients who ... receive a gift card for a dinner for two at the Cheesecake Factory. ...
(Date:2/23/2017)... ... February 23, 2017 , ... On April 13, 2017, ... “Doping in Sport: How the Culture Might Change,” in conjunction with ... symposium will be held at Pepperdine University in Malibu, California. , Sir Philip ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Following receiving CE Marking in Europe ... AMAR is a major milestone for the country where the device was developed ... market in Israel   ... inclusion in the National Health Basket , Israel , ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment of advanced wound ...
(Date:2/24/2017)... Research and Markets has announced the addition of the ... report to their offering. ... The Global Empty Capsules Market is poised to grow at a ... billion by 2025. This industry report analyzes the market ... as regional levels presented in the research scope. The study provides historical ...
(Date:2/24/2017)... , Feb. 24, 2017 Physician General ... Drug and Alcohol Programs Jennifer Smith commended ... providing training for and using naloxone, a life-saving overdose ... McCullough , a recovery specialist and overdose survivor who ... EMS providers. "A significant part of fighting ...
Breaking Medicine Technology: