Navigation Links
Primary Insomnia Tied to Brain Neurochemical Imbalance
Date:11/3/2008

Finding suggests complaint of a 'racing mind' is not just in patient's head

MONDAY, Nov. 3 (HealthDay News) -- Adults with primary insomnia have a specific neurochemical imbalance that makes it more difficult for their brains to settle down for sleep, a new study says.

People with primary insomnia for more than six months have 30 percent less gamma-aminobutyric acid (GABA), a chemical that slows overall activity in many brain areas, according to the report in the Nov. 1 issue of Sleep. A "racing mind" and an inability to shut down at night is a common complaint of people with primary insomnia.

"GABA is reduced in the brain of individuals with insomnia, suggesting overactivity is present not only at the level of excessive thoughts and emotions, but can also be detected at the level of the nervous system," principal investigator John Winkelman of Brigham and Women's Hospital, in Boston, said in an American Academy of Sleep Medicine news release.

While most insomnia occurs in conjunction with another illness or disorder, either physical or mental, or as a side effect of certain medications or substances, primary insomnia occurs without a coexisting condition. Approximately a quarter of people with insomnia suffer from this particular type of the sleep disorder.

The finding suggests that primary insomnia is a manifestation of hyperarousal, a neurobiological state, that Winkelman said helps validate an often misunderstood complaint of insomnia.

"Recognition that insomnia has manifestations in the brain may increase the legitimacy of those who have insomnia and report substantial daytime consequences," he said. "Insomnia is not just a phenomenon observed at night, but has daytime consequences for energy, concentration and mood."

Lower brain GABA levels also have been found in people with major depressive disorder (MDD) and anxiety disorders. As primary insomnia is a critical risk factor in these conditions, the findings could mean GABA deficiencies seen in people with mood and anxiety disorders may be tied to sleep disturbances.

Many of the hypnotic medications most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons, the study also reported.

More information

The American Academy of Sleep Medicine has more about insomnia.



-- Kevin McKeever



SOURCE: American Academy of Sleep Medicine, news release, Nov. 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults
2. Pathwork Tissue of Origin Test Shows Potential to Aid in the Diagnosis of Cancer of Unknown Primary
3. Meijer Honored by Michigan Primary Care Association for Leadership in Promoting Health of Michigan Residents
4. What is the clinical features of primary aortoenteric fistula?
5. Most generalists reluctant to provide primary care for young adults with chronic illness
6. Integrating palliative care for dementia into primary care
7. Patient Centered Primary Care Collaborative Statement on Passage of Medicare Bill
8. Massachusetts Patients Offer Feedback on Their Experiences With Primary Care
9. Primary Care Physicians Prescriptions of Aricept for Alzheimers Disease Will Drop by 20 Percent Following the Availability of Generic Razadyne in December 2008
10. Cardinal Health Formalizes Consolidation of Businesses Into Two Primary Operating and Reporting Segments
11. Disclosing violence to primary care or obstetrics/gynecology physicians most beneficial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Primary Insomnia Tied to Brain Neurochemical Imbalance
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made their ... to an ambitious venture that conjoined the passions of an NBA star, a Liberty ... Liberty community. These shoes will save lives from the rampant infections transmitted through the ...
(Date:8/18/2017)... York, NY (PRWEB) , ... August 18, 2017 ... ... launch of this summer’s edition of “Vision & Hearing,” advocating for active, healthy ... campaign focuses on resources available for individuals with hearing impairments and shares the ...
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez ... consultations to communities throughout the greater DC region, is inaugurating a “New Leash ... rescuing local animals and training them to be companions for veterans in need. ...
(Date:8/18/2017)... ... 18, 2017 , ... The Brian Gifford Agency, an Indiana-based firm providing asset ... of Campagna Academy in a charity drive to provide for at-risk children and teens ... Campagna Academy is a nonprofit organization that has offered critical programs to at-risk and ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active ... hormone replacement therapy and integrative medicine, has become a frontrunner for people seeking ... as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/15/2017)... 15, 2017  AOTI Inc. announced today that its fully owned ... recently opened a New York City Office in Yonkers, ... unique Topical Wound Oxygen (TWO 2 ) homecare therapy. This new ... for Health Care (ACHC) under the company,s DMEPOS accreditation for Home/Durable ... Advanced ...
(Date:8/8/2017)... AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: ... immunology, today reports its financial results for the second ... achievements during the second quarter 2017 and to date: ... multiple clinical development programs for the Company,s lead project, ... 3 pivotal study with BL-8040 as novel stem cell ...
Breaking Medicine Technology: