Navigation Links
Primary Insomnia Tied to Brain Neurochemical Imbalance
Date:11/3/2008

Finding suggests complaint of a 'racing mind' is not just in patient's head

MONDAY, Nov. 3 (HealthDay News) -- Adults with primary insomnia have a specific neurochemical imbalance that makes it more difficult for their brains to settle down for sleep, a new study says.

People with primary insomnia for more than six months have 30 percent less gamma-aminobutyric acid (GABA), a chemical that slows overall activity in many brain areas, according to the report in the Nov. 1 issue of Sleep. A "racing mind" and an inability to shut down at night is a common complaint of people with primary insomnia.

"GABA is reduced in the brain of individuals with insomnia, suggesting overactivity is present not only at the level of excessive thoughts and emotions, but can also be detected at the level of the nervous system," principal investigator John Winkelman of Brigham and Women's Hospital, in Boston, said in an American Academy of Sleep Medicine news release.

While most insomnia occurs in conjunction with another illness or disorder, either physical or mental, or as a side effect of certain medications or substances, primary insomnia occurs without a coexisting condition. Approximately a quarter of people with insomnia suffer from this particular type of the sleep disorder.

The finding suggests that primary insomnia is a manifestation of hyperarousal, a neurobiological state, that Winkelman said helps validate an often misunderstood complaint of insomnia.

"Recognition that insomnia has manifestations in the brain may increase the legitimacy of those who have insomnia and report substantial daytime consequences," he said. "Insomnia is not just a phenomenon observed at night, but has daytime consequences for energy, concentration and mood."

Lower brain GABA levels also have been found in people with major depressive disorder (MDD) and anxiety disorders. As primary insomnia is a critical risk factor in these conditions, the findings could mean GABA deficiencies seen in people with mood and anxiety disorders may be tied to sleep disturbances.

Many of the hypnotic medications most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons, the study also reported.

More information

The American Academy of Sleep Medicine has more about insomnia.



-- Kevin McKeever



SOURCE: American Academy of Sleep Medicine, news release, Nov. 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults
2. Pathwork Tissue of Origin Test Shows Potential to Aid in the Diagnosis of Cancer of Unknown Primary
3. Meijer Honored by Michigan Primary Care Association for Leadership in Promoting Health of Michigan Residents
4. What is the clinical features of primary aortoenteric fistula?
5. Most generalists reluctant to provide primary care for young adults with chronic illness
6. Integrating palliative care for dementia into primary care
7. Patient Centered Primary Care Collaborative Statement on Passage of Medicare Bill
8. Massachusetts Patients Offer Feedback on Their Experiences With Primary Care
9. Primary Care Physicians Prescriptions of Aricept for Alzheimers Disease Will Drop by 20 Percent Following the Availability of Generic Razadyne in December 2008
10. Cardinal Health Formalizes Consolidation of Businesses Into Two Primary Operating and Reporting Segments
11. Disclosing violence to primary care or obstetrics/gynecology physicians most beneficial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Primary Insomnia Tied to Brain Neurochemical Imbalance
(Date:4/25/2017)... Greifensee, Switzerland (PRWEB) , ... April 25, 2017 ... ... product innovation targets, they rely on contracted partners to help with process innovation ... years of combined drug formulation experience along with state-of-the-art analytical equipment in support ...
(Date:4/25/2017)... ... April 25, 2017 , ... Somnoware, a leading ... patient care management module. Using this new feature, sleep physicians can now predict ... on continuous positive airway pressure (CPAP), oral, or other forms of sleep apnea ...
(Date:4/24/2017)... ... April 24, 2017 , ... Emmanuel College is ... professionals advance their careers. Beginning in the fall of 2017, Emmanuel’s program will allow ... as few as 16 months and for as little as $14,528. These changes will ...
(Date:4/24/2017)... ... April 24, 2017 , ... As part of the nationwide ... honor the victims of the Holocaust and Nazi persecution, Center for Medicine after ... Auschwitz on its CMATH Champions trip to Germany and Poland next week. , The ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Sean Fay ... Oxiclean, Space Bag, Sonicare Toothbrush, Juiceman Juicer, and the George Foreman Grill (which sold ... any other marketer in the last 25 years. , Now, due to changes in ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  Zimmer Biomet Holdings, Inc. (NYSE and ... announced that it will be participating in the Deutsche ... InterContinental Hotel in Boston, Massachusetts ... at 11:20 a.m. Eastern Time. A live ... Biomet,s Investor Relations website at http://investor.zimmerbiomet.com .  The ...
(Date:4/20/2017)... , April 20, 2017  RXi Pharmaceuticals ... innovative therapeutics that address significant unmet medical needs, ... from the Company,s consumer product development program, based ... the Society for Investigative Dermatology (SID) 76 th ... advance and promote the sciences relevant to skin ...
(Date:4/20/2017)... April 20, 2017  CVS Pharmacy, the retail ... a new store design to enhance the retail ... food, health-focused products and expanded beauty selections paired ... customers discover new offerings. Together with its innovative ... of the customer experience at CVS Pharmacy.  ...
Breaking Medicine Technology: