Navigation Links
Prickly protein
Date:2/6/2014

A genetic mechanism that controls the production of a large spike-like protein on the surface of Staphylococcus aureus (staph) bacteria alters the ability of the bacteria to form clumps and to cause disease, according to a new University of Iowa study.

The new study is the first to link this genetic mechanism to the production of the giant surface protein and to clumping behavior in bacteria. It is also the first time that clumping behavior has been associated with endocarditis, a serious infection of heart valves that kills 20,000 Americans each year. The findings were published in the Dec. 2103 issue of the journal PLOS Pathogens.

Under normal conditions, staph bacteria interact with proteins in human blood to form aggregates, or clumps. This clumping behavior has been associated with pathogenesis -- the ability of bacteria to cause disease. However, the mechanisms that control clumping are not well understood.

In the process of investigating how staph bacteria regulate cell-to-cell interactions, researchers at the UI Carver College of Medicine discovered a mutant strain of staph that does not clump at all in the presence of blood proteins.

Further investigation revealed that the clumping defect is due to disruption of a genetic signaling mechanism used by bacteria to sense and respond to their environment. The study shows that when the mechanism is disrupted, the giant surface protein is overproduced -- giving the cells a spiny, or "porcupine-like" appearance -- and the bacteria lose their ability to form clumps.

Importantly, the researchers led by Alexander Horswill, PhD, associate professor of microbiology, found that this clumping defect also makes the bacteria less dangerous in an experimental model of the serious staph infection, endocarditis.

Specifically, the team showed that wild type bacteria cause much larger vegetations (aggregates of bacteria) on the heart valves and are mor
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
2. Critical protein discovered for healthy cell growth in mammals
3. Researchers find changes to protein SirT1
4. 2 proteins compete for 1 port on a growth factor; 1 promotes metastasis, the other blocks it
5. NCCS scientists discover gene regulation is dependent on protein ANP32E
6. Better protein capture a boon for drug manufacturers
7. Homemade Protein Bar Recipe Looks to Cut Out Extra Additives from Health Foods, Believes Carol Newman of The BioGirl Health Show
8. New NuGo Stronger: First Non-GMO High Protein Bar with rBGH-Free Whey Protein for Serious Athletes
9. Tricky protein may help HIV vaccine development
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Rock And Rho: Proteins that help cancer cells groove
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prickly protein
(Date:7/24/2014)... York (PRWEB) July 24, 2014 ... ( http://www.injurybeacon.com/granuflo-dialysis/lawsuit/ ) in the U.S. District ... protective order for plaintiff medical information covered by ... According to the July 16th Order, U.S. District ... for Fresenius Medical Care the right to ...
(Date:7/24/2014)... Amy Norton HealthDay Reporter ... sex-crazed teenage boy may be dead wrong, according to a small ... In interviews with 33 boys between the ages of 14 ... with a girl for the closeness and trust. Very few boasted ... starting a relationship with a girl. "In our culture, we ...
(Date:7/24/2014)... HealthDay Reporter THURSDAY, July ... don,t view their kids as unhealthy or recognize the health ... study. The children of the families surveyed for the ... Children,s Hospital in Providence, R.I. "A third categorized their ... Dr. Kyung Rhee, now an assistant professor of pediatrics at ...
(Date:7/24/2014)... found a way to delay or even prevent Alzheimer,s ... the anti-aging protein Klotho can prevent neuron death in ... These findings currently appear in the Journal of ... most frequent age-related dementia affecting 5.4 million Americans including ... more than 40 percent of people over the age ...
(Date:7/24/2014)... 24, 2014 News Facts , ... has achieved certification for compliance with Department of ... by the DoD Information Assurance Certification and Accreditation ... identified within the DoD as the Enterprise Clinical ... designation from the U.S. Army Medical Materiel Agency. ...
Breaking Medicine News(10 mins):Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 2Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 3Health News:Parents of Obese Kids Often View Them as Healthy 2Health News:Parents of Obese Kids Often View Them as Healthy 3Health News:BU researchers discover that Klotho is neuroprotective against Alzheimer's disease 2Health News:Perceptive Software Achieves DIACAP Certification for Vendor Neutral Archive Solution to Support U.S. Department of Defense Integrated Clinical Systems Program 2Health News:Perceptive Software Achieves DIACAP Certification for Vendor Neutral Archive Solution to Support U.S. Department of Defense Integrated Clinical Systems Program 3Health News:Perceptive Software Achieves DIACAP Certification for Vendor Neutral Archive Solution to Support U.S. Department of Defense Integrated Clinical Systems Program 4
... way to scan brain tumors and predict which ones will ... ever starts treatment. By linking high water movement in ... 70 percent accuracy which patients, tumors were the least likely ... considers himself lucky. When his aggressive brain cancer returned ...
... , , , , ... Hospital scientists lead survey of genome that identifies new genes ... MEMPHIS, Tenn., Aug. 16 Scientists at St. Jude Children,s Research ... percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may ...
... never met Sumita B. Mitra, Ph.D. But your teeth ... genius has helped restore millions of decayed, broken, or discolored ... a glass make that water, please to toast ... Cadotte. Millions of people might well do exactly that. Mickols ...
... Aug. 16, 2009 Attention all smokeless tobacco users! ... chewing tobacco are safe because they don,t burn and produce ... well-researched tobacco hazards, nitrosamines and nicotine, has discovered a single ... tobacco exposes the user to the same amount of another ...
... July 30, 2009 Pregnant women have a higher incidence ... months due to dehydration, according to a study conducted by ... retrospective population-based study was published in the July issue of ... objective of the study was to determine whether the summer ...
... Comprehensive health reform proposals now before Congress could help ... 19-29 gain coverage, and such reforms would also help ... lose it, according to a new Commonwealth Fund report. ... in Medicaid and a health insurance exchange with a ...
Cached Medicine News:Health News:A crystal ball for brain cancer? 2Health News:A crystal ball for brain cancer? 3Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 2Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 3Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 4Health News:'Heroes of Chemistry' for saving teeth, clean water, new high blood pressure drug 2Health News:'Heroes of Chemistry' for saving teeth, clean water, new high blood pressure drug 3Health News:'Heroes of Chemistry' for saving teeth, clean water, new high blood pressure drug 4Health News:New study expands the list of hazardous chemicals in smokeless tobacco 2Health News:Summer heat increases risk of amniotic fluid level deficiency, Ben-Gurion University study reveals 2Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 2Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 3
(Date:7/24/2014)... CAMPBELL, Calif. , July 24, 2014 /PRNewswire/ ... the development of novel interventional devices to facilitate ... United States Patent and Trademark Office has issued ... core technology behind the company,s Lazarus Cover TM ... The Lazarus ReCover is a single-component stent-retriever ...
(Date:7/24/2014)... 2014 Consolidated Net Profit increased by 43.65 ...   , India Business grew by 20.87% to Rs. ... 4,886.70 Mn Rest of World (ROW) Business grew by ... by 34.53% to Rs. 977.26 Mn Latin America Business ... Glenmark Pharmaceuticals Limited, the research-led global integrated pharmaceutical company, today ...
(Date:7/24/2014)... MEMPHIS, Tenn. , July 24, 2014  In ... time, one in 25 patients has at least one ... and Prevention. What,s more, many of these infections prove ... are causing an alarming number of patient deaths per ... of industry conversation. Consequently, a stronger ...
Breaking Medicine Technology:Lazarus Effect Receives Notice of Allowance for New US Patent Covering Core Protection Technology 2Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 2Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 3Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 4Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 2Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 3
... SAN DIEGO , April 26 ADVENTRX Pharmaceuticals, Inc. (NYSE ... reverse stock split is now effective, and the Company,s common stock will ... the market opens today. , , ... The reverse stock split is intended to satisfy the NYSE Amex,s determination, ...
... Israel , April 26, 2010 PolyTouch Medical Ltd., a,leading developer ... LeBlanc , MD, MBA, FACS as Medical Advisor. , ... Dr. Karl LeBlanc , past president ... performed the first,laparoscopic hernia repair in 1991 and has since written three medical ...
Cached Medicine Technology:ADVENTRX Reverse Split Effective; Trading on Adjusted Basis Begins Today 2ADVENTRX Reverse Split Effective; Trading on Adjusted Basis Begins Today 3PolyTouch Medical Ltd. Announces the Appointment of Karl A. LeBlanc, MD, MBA, FACS as Medical Advisor 2PolyTouch Medical Ltd. Announces the Appointment of Karl A. LeBlanc, MD, MBA, FACS as Medical Advisor 3
TEW hooked micro-retractor blade set....
... blades are designed for the retraction of nerves, ... the brain. Equalizes brain retraction pressure. Decreases shear ... Used in conjunction with the Budde Halo Retractor. ... wide and 2 mm and 4 mm wide. ...
Mini-Vise....
The Budde Halo Retractor Side Rail Support is designed for the adaptation and attachment of the Budde Halo Brain Retractor System to the operating room table when a conventional skull clamp is not us...
Medicine Products: