Navigation Links
Previous pulmonary disease linked to increased lung cancer risk in large study

Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals.

"Associations between various respiratory diseases and lung cancer have been shown in earlier studies, but few of these studies considered multiple respiratory diseases simultaneously," said researcher Ann Olsson, PhD, of the International Agency for Research in Cancer in Lyon, France. "In our pooled analysis of seven case-control studies involving more than 12,500 cases and 14,900 controls, we found associations between lung cancer and chronic bronchitis, emphysema, and pneumonia, with a greater increased lung cancer risk among subjects with all three of these conditions."

The findings were published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Data on five previous respiratory diseases (chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma) were collected by self-report. Statistical analyses were adjusted for study center, age, employment in an occupation with an excess risk of lung cancer, level of education and detailed smoking habits.

Pneumonia and chronic bronchitis were the most frequently reported previous respiratory diseases. In analyses adjusting for other respiratory diseases and smoking, chronic bronchitis and emphysema were positively associated with lung cancer, with odds ratios among men of 1.33 (95% CI 1.20-1.48) for bronchitis and 1.50 (95% CI 1.21-1.87) for emphysema. A positive association was also found between pneumonia diagnosed two or fewer years prior and lung cancer (OR=3.31; CI 2.33-4.70 for men), Asthma had an inverse association with lung cancer risk, and no association was found between tuberculosis and lung cancer.

Patients with co-occurring chronic bronchitis, emphysema and pneumonia had a higher risk of lung cancer than those with chronic bronchitis only. There was no association between chronic bronchitis and lung cancer among patients with co-occurring asthma or tuberculosis.

"The variations in the associations between lung cancer and different patterns of previous respiratory diseases that we observed in our study may indicate differences in the underlying etiological mechanisms," said Dr. Olsson. "Better understanding of these associations may help guide the type and frequency of clinical surveillance needed for patients with each of these diseases."

Contact: Nathaniel Dunford
American Thoracic Society

Related medicine news :

1. Diagnostic yield of colonoscopy for melena after nondiagnostic upper endoscopy is lower than previously reported
2. Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought
3. Cancer may require simpler genetic mutations than previously thought
4. HIV superinfection in Uganda may be more common than previously thought, study finds
5. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
6. Benefits of HIV drugs rise -- but less than previously believed, Penn study shows
7. HIV suppression not as good as previously thought, largest study of viral-load blood tests show
8. Survival rates for premature babies in high-level NICUs are better than previously reported
9. The aging brain is more malleable than previously believed
10. Physicians at Pain Care Bring Hope to Hundreds of Pain Management Patients Who Previously Had None Through Use of a New Procedure Called Spinal Cord Stimulation
11. Previous studies on toxic effects of BPA couldnt be reproduced
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the toilets were," said an inventor from Hillside, N.J. "Many people catch diseases ... cover so that individuals will always be protected from germs." , He developed ...
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of the ... 2016, at Caesars Palace in Las Vegas with a pre-conference session on a ...
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its ... exclusive list of CAAHEP accredited colleges, as only one of twelve colleges and universities ...
(Date:11/26/2015)... Marne, MI (PRWEB) , ... November 26, 2015 ... ... center for substance abuse located in central Michigan, have come together on Thanksgiving ... a specially produced video, available for viewing on the Serenity Point YouTube channel, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories and ... offered by healthcare staffing agency Aureus Medical Group . These fields, ... 2015 among those searching for healthcare jobs through the company’s website, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... PUNE, India , November ... --> ... / personal emergency response system ... grow steadily for 5 years ... growing region expected to see ...
(Date:11/26/2015)... November 26, 2015 --> ... combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... has found that immunotherapy can be efficiently combined with ...
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 Research and ... "Asia Pacific Cardiac Pacemaker Market Outlook to 2019 - ... Drive the Demand " report to their offering. ... --> Boston scientific and others. ... global players including Medtronic, Biotronik, Boston ...
Breaking Medicine Technology: