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Preview of articles to be published Jan. 3, 2012
Date:1/3/2012

rvival. The researchers believe that this work shows that these two mutations are sufficient to drive tumor development, and hope that their model system will be useful for the testing of new therapeutics.

TITLE: An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

AUTHOR CONTACT:
Wayne Phillips
Peter MacCallum Cancer Centre, Melbourne, AUS
Phone: +61402277123; E-mail: wayne.phillips@petermac.org

View this article at: http://www.jci.org/articles/view/59309?key=6304f99669c209a9087e

INFECTIOUS DISEASE

New technique to identify viral vaccine targets

Herpes simplex virus type 1 (HSV-1) is a common human virus that causes cold sores, can lead to brain damage and blindness, and causes some genital herpes. An effective vaccine for HSV-1 will need to stimulate responses from multiple types of immune cells, including both helper and memory T cells. To do so, scientists must first identify the antigens from the virus capable of stimulating T cells. In new research, David Koelle and colleagues, at the University of Washington, Seattle, developed a system to stimulate memory and helper T cells from HSV-1 positive patients, and then isolate those that were specifically reactive to HSV-1. This technique led to the identification of previously unidentified HSV-1 vaccine candidate genes. The researchers then successfully applied their technique to identify T cell antigens of the vaccinia virus, suggesting that it may be useful for the identification of T cell vaccine targets for many other viruses.

TITLE: Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

AUTHOR CONTACT:

David Koelle
University of Washington, Se
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Contact: Karen Honey
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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