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Preview of articles to be published Jan. 3, 2012
Date:1/3/2012

)-502-5614; Fax: 415-502-5641; E-mail: ljp@ucsf.edu
View this article at: http://www.jci.org/articles/view/58470?key=4c19485504835cbbf900

ONCOLOGY

CHCHD4 helps cancer cells adapt to ch-ch-ch-ch- changes in oxygen availability

The ability of cells to respond to changes in oxygen level is a key determinant of their survival. In many cancer cells, for example, one component of the hypoxia inducible factor complex (HIF-1α) is chronically upregulated, which can result in increased blood vessel density and thus nutrient and oxygen delivery to growing tumors. In this paper, Margaret Ashcroft and her team, at University College, London, describe a mitochondrial protein called CHCHD4 that increases the rate at which cells consume and metabolize oxygen, and is critical for the induction of HIF-1α expression in response to low oxygen levels. They found that decreasing CHCHD4 expression inhibits the ability of cancer cells to form tumors. Furthermore, in cancer patients, increased CHCHD4 expression correlated with the hypoxia gene expression signature, increasing tumor grade, and reduced patient survival. This research identifies a mechanism that is critical for regulating the hypoxic response in tumors, and could indicate a new direction for those searching for strategies to fight tumor growth.

TITLE: Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

AUTHOR CONTACT:

Margaret Ashcroft
University College London, Rayne Inst, London, GBR
Phone: 02076790799; E-mail: m.ashcroft@ucl.ac.uk
View this article at: http://www.jci.org/articles/view/5
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Contact: Karen Honey
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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