Navigation Links
Preview of articles to be published Jan. 3, 2012
Date:1/3/2012

)-502-5614; Fax: 415-502-5641; E-mail: ljp@ucsf.edu
View this article at: http://www.jci.org/articles/view/58470?key=4c19485504835cbbf900


ONCOLOGY

CHCHD4 helps cancer cells adapt to ch-ch-ch-ch- changes in oxygen availability

The ability of cells to respond to changes in oxygen level is a key determinant of their survival. In many cancer cells, for example, one component of the hypoxia inducible factor complex (HIF-1α) is chronically upregulated, which can result in increased blood vessel density and thus nutrient and oxygen delivery to growing tumors. In this paper, Margaret Ashcroft and her team, at University College, London, describe a mitochondrial protein called CHCHD4 that increases the rate at which cells consume and metabolize oxygen, and is critical for the induction of HIF-1α expression in response to low oxygen levels. They found that decreasing CHCHD4 expression inhibits the ability of cancer cells to form tumors. Furthermore, in cancer patients, increased CHCHD4 expression correlated with the hypoxia gene expression signature, increasing tumor grade, and reduced patient survival. This research identifies a mechanism that is critical for regulating the hypoxic response in tumors, and could indicate a new direction for those searching for strategies to fight tumor growth.

TITLE: Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

AUTHOR CONTACT:

Margaret Ashcroft
University College London, Rayne Inst, London, GBR
Phone: 02076790799; E-mail: m.ashcroft@ucl.ac.uk
View this article at: http://www.jci.org/articles/view/5
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. FDA-USP workshop to preview updated OTC standards
2. DDW 2010 telebriefing: Preview the latest research and hot topics
3. Nanoparticles help Mayo Clinic researcher deliver steroids to retina
4. Nanoparticles help researchers deliver steroids to retina
5. New device uses gold nanoparticles to test for lung cancer
6. Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer
7. Big Tobacco knew radioactive particles in cigarettes posed cancer risk but kept quiet
8. Could engineered fatty particles help prevent AIDS?
9. Consumers close encounters with nanoparticles
10. Academics guest authoring ghostwritten medical journal articles should be charged with fraud
11. UGA researchers use gold nanoparticles to diagnose flu in minutes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Active Aging Week is a week-long observance ... members of society and promotes the benefits of leading ... a boutique retirement community located at 1200 Overlook Drive, ... of Cyber-Seniors - a humorous and heartwarming documentary. , ... this great film,” says Thomas Cloutier, Executive Director for ...
(Date:9/18/2014)... September 18, 2014 Alexandria, VA — ... today that 10 more communities have joined the growing ... health department accreditation. The decisions bring the number of ... 54. PHAB is the non-profit organization that administers the ... and protect the health of the public by advancing ...
(Date:9/18/2014)... Reinberg HealthDay Reporter , THURSDAY, Sept. ... outbreak in West Africa is starting to spread faster than ever, ... cases of the deadly viral infection were reported in just one ... than 5,300, with roughly half of those reported in the past ... deaths now tops 2,600. WHO has estimated that as many ...
(Date:9/18/2014)... CA (PRWEB) September 18, 2014 Companies ... and refine carbon dioxide, selling it to downstream industries ... markets for carbon dioxide are food and beverage manufacturers. ... such as fruits, vegetables or pizzas. The gas is ... manufacturers use the compound to carbonate soft drinks, beer ...
(Date:9/18/2014)... exercise is good for you. But new research from ... an added benefit for cancer patients undergoing chemotherapy. , ... found that combining exercise with chemotherapy shrunk tumors more ... professor in the School of Nursing and director of ... the senior author on the study, which appears in ...
Breaking Medicine News(10 mins):Health News:In Support of Active Aging Week, a Lake Oswego Retirement Community Will Get a Sneak Peek at an Inter-Generational Documentary – Cyber-Seniors 2Health News:Ten More Communities Reaping Benefits of National Accreditation 2Health News:Ten More Communities Reaping Benefits of National Accreditation 3Health News:Ten More Communities Reaping Benefits of National Accreditation 4Health News:New Ebola Cases Top 700 in Just One Week, Officials Report 2Health News:New Ebola Cases Top 700 in Just One Week, Officials Report 3Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Exercise boosts tumor-fighting ability of chemotherapy, Penn team finds 2
... medical center,s dramatic growth and steady ... over nearly four decades, GLEN BURNIE, Md., Sept. 18 ... those as president and CEO,James R. Walker has announced his ... night at the BWMC Board of Directors meeting. (Photo: ...
... Expanded leave,benefits for military families is a ... to balance the needs of employees and employers, ... the world,s largest,association of human resource professionals., ... for members of the,National Guard, Reservists and their ...
... Quality Forum (NQF) and The Joint Commission today announced the,2007 ... Quality,Awards. Honorees were selected in all four award categories., ... ACHIEVEMENT (2 RECIPIENTS), -- Flaura Koplin Winston, M.D., Ph.D. ... Prevention at The Children,s Hospital of Philadelphia and the ...
... is quiet almost too quiet in movies, it is ... good guys. This holds true for the genes that protect against ... Ohio, have learned. They identified a panel of 15 genes that ... becomes quiet almost too quiet -- it could mean they ...
... In an 18-year-study on attention-deficit hyperactivity disorder (ADHD), ... stimulants is associated with improved long-term academic success ... are the first population-based data to show stimulant ... A related Mayo Clinic study reveals that compared ...
... study finds , , TUESDAY, Sept. 18 (HealthDay News) -- ... by looking at Web sites can leave would-be patients ... study finds. , In looking over six hospital-comparison Web ... inappropriate or incomplete standards to measure a center,s quality, ...
Cached Medicine News:Health News:BWMC President and CEO Announces Retirement 2Health News:BWMC President and CEO Announces Retirement 3Health News:SHRM Testimony Urges Congress to Fix FMLA 2Health News:2007 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 2Health News:2007 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 3Health News:2007 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 4Health News:2007 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 5Health News:Test for lung cancer looks for discomforting quiet among protective genes 2Health News:Test for lung cancer looks for discomforting quiet among protective genes 3Health News:Mayo Clinic study indicates medication for ADHD may help student outcomes 2Health News:Mayo Clinic study indicates medication for ADHD may help student outcomes 3Health News:Hospital Quality Info on Web Can Be Misleading 2Health News:Hospital Quality Info on Web Can Be Misleading 3
(Date:9/18/2014)... 18, 2014 According to ... & Intravascular Systems- Warming & Cooling), Application (Acute ... & Anesthesiologist, Nursing & Paramedical Staff) - Global ... report studies the global Temperature Management Market over ... market is expected to reach $2.5 Billion by ...
(Date:9/18/2014)... 18, 2014 This BCC Research report discusses the medical ... market growth and size, and opportunities for different devices and ... 2018. Patent analysis in the report focuses on technological trends ... Europe and Japan . ... discuss the global medical device technologies market. - Analyze market ...
(Date:9/18/2014)... FRANCISCO , Sept. 18, 2014   Fruit ... has secured an initial seed round of funding. ... investments, was led by a series of individual investors, ... investors whom participated in the initial round are; ... Valley Medical Center Urologist Stacy Childs, Rapha Family Medicine ...
Breaking Medicine Technology:Temperature Management Market Worth $2.5 Billion by 2019 2Temperature Management Market Worth $2.5 Billion by 2019 3Temperature Management Market Worth $2.5 Billion by 2019 4Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3
... Md., Sept. 28 Sleep Solutions, the pioneer ... obstructive sleep apnea (OSA), has changed its name to NovaSom, ... name to better reflect its history and commitment to providing ... market for the diagnosis of obstructive sleep apnea (OSA), said ...
... Deval Patrick and Massachusetts Life Sciences Center President & ... Inc. CEO Geoff MacKay and employees, to celebrate the ... Dan Road in Canton.   Organogenesis kicked ... cell based product has been approved for the treatment ...
Cached Medicine Technology:Sleep Solutions, Inc. Re-incorporates as NovaSom, Inc. 2Sleep Solutions, Inc. Re-incorporates as NovaSom, Inc. 3Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 2Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 3Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 4
... suspension in methanol for faster, more ... histology smears. Our special manufacturing process ... cellular elements producing unequaled definition of ... unexcelled brilliance in the resulting smear. ...
... ideal for stat, routine or back-up staining. ... seconds) and bone marrow (20-30 seconds). Our ... particles which yield excellent color intensity and ... steps involved in the Wright's staining procedure ...
... fast, single-solution staining, Hema-Quik II ... slides into stain solution for ... to deionized water for five ... second time by dipping quickly ...
... Stain is ideal for stat, routine or ... smears and bone marrow. Our unique manufacturing ... yield excellent color intensity and morphological differentiation. ... in the Wright's staining procedure and includes ...
Medicine Products: