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Preview of articles to be published Jan. 3, 2012
Date:1/3/2012

ancy and poor prognosis in many tumor types. In new research, Alfredo Fusco and colleagues, of Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, in Naples, Italy, generated mice that lacked Cbx7 expression. Remarkably, these mutant mice spontaneously developed malignant growths in the liver and lung. The researchers also demonstrated that CBX7 acts in part by regulating expression of the cell cycle protein CyclinE. These results show that Cbx7 normally acts as a tumor suppressor, keeping cell growth in check.

TITLE: CBX7 is a tumor suppressor in mice and humans

AUTHOR CONTACT:
Alfredo Fusco
CNR/Istituto di Endocrinologia e Oncologia Sperimentale, Naples, ITA
Phone: 0039-081-7463602; E-mail: alfusco@unina.it
View this article at: http://www.jci.org/articles/view/58620?key=91439f519d2c6db02b01

DERMATOLOGY

Zinc-deficient individuals irritated by ATP

Zinc (Zn) is an essential trace element. Zn deficiency can be inherited or acquired, for example as a result of low dietary Zn intake. It has many clinical manifestations, including secondary bacterial and fungal infection of skin lesions due to impaired immune function, however the mechanism through which Zn-deficient individuals develop skin inflammation is unknown. In this paper, Kawamura and colleagues, of the University of Yamanashi, in Japan, determined that mice fed a Zn-deficient diet (ZD mice) develop a severe irritant contact dermatitis (ICD) that has the histological features of the skin inflammation seen in Zn-deficient individuals. Detailed analysis revealed that irritant- injured keratinocytes released ATP causing ICD in this model. The ZD mice had decreased numbers of epidermal Langerhans cells (LCs), which are known to hydrolyze ATP and thereby provide protection against ATP-mediated inflammatory
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Contact: Karen Honey
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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