Navigation Links
Preventive oophorectomy reduces risk of death by 77 percent for women with BRCA mutation
Date:2/24/2014

TORONTO, ON, February 24, 2014 Women who carry a BRCA gene mutation and opt for a preventive oophorectomy, or ovary removal surgery, have a 77 per cent lower risk of death than those who do not, according to a new study led by Women's College Hospital's Amy Finch and Dr. Steven Narod.

Research has long shown that preventive oophorectomy reduces the risks of ovarian and breast cancers in women with a BRCA gene mutation, but the best age for women to have the surgery and its impact on mortality has not been well studied. The findings by Finch and colleagues, published today in the Journal of Clinical Oncology, are the first to look at these effects among a large cohort of women over a nearly six-year followup period.

"Scientific evidence clearly shows removal of a woman's ovaries and fallopian tubes is very effective in preventing both breast and ovarian cancer in women with a BRCA mutation," said Finch, a researcher at Women's College Research Institute and the study's lead author. "But the real question has been at what age these women should have the surgery to best diminish their chance of developing cancer."

In the study, researchers evaluated the effect of a preventive oophorectomy in reducing death and the risk of ovarian, fallopian tube or peritoneal cancer in 5, 783 women with a BRCA gene mutation. They found the surgery was associated with:

  • An 80 per cent reduction in the risk of ovarian, fallopian and peritoneal cancer
  • A 77 per cent lower risk of death from all causes and
  • A 68 per cent lower risk of death from all causes in women who previously had breast cancer

"Our study supports the notion that women who carry a BRCA gene mutation will have a much lower risk of developing or dying from cancer if they have an oophorectomy at age 35," said Dr. Steven Narod, a co-author of the study and senior scientist at Women's College Research Institute. "If a woman with a BRCA1 mutation opts to delay the surgery until age 40 or 50, her chance of developing ovarian, fallopian tube or peritoneal cancers jumps to 4 and 14.2 per cent, respectively."

While oophorectomy is a safe procedure, it can carry some complications, including premature menopause.

"After an oophorectomy, the long-term effects on a woman's cardiovascular health and her bone health are less well known, and further research is needed," Finch added.

Finch and Dr. Narod, along and colleagues from Women's College Hospital and the University Health Network, are now examining these potential impacts in a new study to gain a better understanding of the risks of a preventive oophorectomy for women with a BRCA mutation.

While the decision to undergo oophorectomy is life altering, particularly for young women, these findings showing the clear benefit of this surgery on cancer risk and mortality and will strengthen the recommendation for this surgery, the researchers said.


'/>"/>

Contact: Julie Saccone
julie.saccone@wchospital.ca
416-323-6400 x4054
Women's College Hospital
Source:Eurekalert

Related medicine news :

1. Interactive personal health records increase clinical preventive services
2. Preventive Measures Pay Off for Those at Risk of Stroke
3. Mild HIV type slows development of AIDS and makes new preventive treatments possible
4. VCU medical team recommends preventive antibiotic for COPD sufferers
5. New gene offers hope for preventive medicine against fractures
6. Preventive screening for sudden cardiac death in young athletes debated
7. Metabolic biomarkers for preventive molecular medicine
8. The American College of Preventive Medicine Heads to Phoenix to host Annual Meeting
9. Many Allergic to Fire Ants Sting Dont Get Preventive Shots
10. Millions Got Free Preventive Care Due to Health Law, HHS Says
11. Is your migraine preventive treatment balanced between drugs benefits and harms?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest ... the greater Dallas, Miami, and Raleigh regions, is organizing an extended charity drive ... rare and deadly chromosome abnormality. , After struggling since birth with several health ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of ... of excellence for the field of eating disorders, announces the opening of early ... in Orlando, Florida at the Omni Resort at ChampionsGate. , The ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: