Navigation Links
Preventive oophorectomy reduces risk of death by 77 percent for women with BRCA mutation
Date:2/24/2014

TORONTO, ON, February 24, 2014 Women who carry a BRCA gene mutation and opt for a preventive oophorectomy, or ovary removal surgery, have a 77 per cent lower risk of death than those who do not, according to a new study led by Women's College Hospital's Amy Finch and Dr. Steven Narod.

Research has long shown that preventive oophorectomy reduces the risks of ovarian and breast cancers in women with a BRCA gene mutation, but the best age for women to have the surgery and its impact on mortality has not been well studied. The findings by Finch and colleagues, published today in the Journal of Clinical Oncology, are the first to look at these effects among a large cohort of women over a nearly six-year followup period.

"Scientific evidence clearly shows removal of a woman's ovaries and fallopian tubes is very effective in preventing both breast and ovarian cancer in women with a BRCA mutation," said Finch, a researcher at Women's College Research Institute and the study's lead author. "But the real question has been at what age these women should have the surgery to best diminish their chance of developing cancer."

In the study, researchers evaluated the effect of a preventive oophorectomy in reducing death and the risk of ovarian, fallopian tube or peritoneal cancer in 5, 783 women with a BRCA gene mutation. They found the surgery was associated with:

  • An 80 per cent reduction in the risk of ovarian, fallopian and peritoneal cancer
  • A 77 per cent lower risk of death from all causes and
  • A 68 per cent lower risk of death from all causes in women who previously had breast cancer

"Our study supports the notion that women who carry a BRCA gene mutation will have a much lower risk of developing or dying from cancer if they have an oophorectomy at age 35," said Dr. Steven Narod, a co-author of the study and senior scientist at Women's College Research Institute. "If a woman with a BRCA1 mutation opts to delay the surgery until age 40 or 50, her chance of developing ovarian, fallopian tube or peritoneal cancers jumps to 4 and 14.2 per cent, respectively."

While oophorectomy is a safe procedure, it can carry some complications, including premature menopause.

"After an oophorectomy, the long-term effects on a woman's cardiovascular health and her bone health are less well known, and further research is needed," Finch added.

Finch and Dr. Narod, along and colleagues from Women's College Hospital and the University Health Network, are now examining these potential impacts in a new study to gain a better understanding of the risks of a preventive oophorectomy for women with a BRCA mutation.

While the decision to undergo oophorectomy is life altering, particularly for young women, these findings showing the clear benefit of this surgery on cancer risk and mortality and will strengthen the recommendation for this surgery, the researchers said.


'/>"/>

Contact: Julie Saccone
julie.saccone@wchospital.ca
416-323-6400 x4054
Women's College Hospital
Source:Eurekalert

Related medicine news :

1. Interactive personal health records increase clinical preventive services
2. Preventive Measures Pay Off for Those at Risk of Stroke
3. Mild HIV type slows development of AIDS and makes new preventive treatments possible
4. VCU medical team recommends preventive antibiotic for COPD sufferers
5. New gene offers hope for preventive medicine against fractures
6. Preventive screening for sudden cardiac death in young athletes debated
7. Metabolic biomarkers for preventive molecular medicine
8. The American College of Preventive Medicine Heads to Phoenix to host Annual Meeting
9. Many Allergic to Fire Ants Sting Dont Get Preventive Shots
10. Millions Got Free Preventive Care Due to Health Law, HHS Says
11. Is your migraine preventive treatment balanced between drugs benefits and harms?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... 2017 , ... A product of digesting a micronutrient found in soy may ... eating soy foods, while others do not, a University of Pittsburgh Graduate School of ... substance made by some types of “good” gut bacteria when they metabolize isoflavones (micronutrients ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five percent ... those report that family members or friends have also commented about their poor ... loss wear hearing aids. One reason, suggested by 89 percent of American respondents, ...
(Date:2/22/2017)... ... 22, 2017 , ... Super-Sod will attend the Athens Home Show with a ... A shift from Super-Sod’s simple Athens Home Show booth of 2016, this year’s exhibit ... plant manager Chris Roquemore constructed furniture from recycled pallet wood at the Super-Sod farm ...
(Date:2/22/2017)... ... February 22, 2017 , ... Social media marketing is transitioning ... and health systems. Smith & Jones’ delves into this insight and more in its ... Smith & Jones David Vener meets up with social media strategist and partner of ...
(Date:2/22/2017)... ... February 22, 2017 , ... BrightStar Care Charleston ... of the Medical University of South Carolina (MUSC) Center on Aging’s Senior Expo ... “MUSC’s Center on Aging is a tremendous resource in our community. We are thrilled ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... --  Known for selling everyday household products commonly found ... California urologist Dr. Ron ... the British conglomerate that makes those products – it ... her late husband,s invention, business plans, and other trade ... until his violent death in 2013, filed suit yesterday ...
(Date:2/22/2017)... Pharma announced today the completion of its executive management ... were added to form an executive team that will ... the implementation and administration of its newly executed strategic ... companies. Effective as of February ... following eight members reporting to Robert DiCrisci : ...
(Date:2/22/2017)... , Feb. 22, 2017 Henry ... an exclusive distribution agreement with Rijuven, which develops ... diagnostic device to medical practitioners. ... electrocardiogram (ECG) and heart sound signals, transmits real-time ... and offers cloud-based analysis to help physicians provide ...
Breaking Medicine Technology: