Navigation Links
Preventive Antibiotics Help Some Kids Fend Off Urinary Infections
Date:10/28/2009

Modest reduction may be worthwhile for those most at risk, experts say ,,,,

WEDNESDAY, Oct. 28 (HealthDay News) -- Children who are predisposed to recurrent urinary tract infections are commonly treated with preventive antibiotics, and a new Australian study suggests that such prophylactic therapy may have at least a modest effect.

Only 13 percent of youngsters who were given the antibiotic combination of trimethoprim plus sulfamethoxazole (brand names Bactrim and Septra) developed a urinary tract infection while on the medication compared to 19 percent of the children on a placebo, according to the study.

"There was a small benefit across many groups of children, which will be worthwhile in some -- e.g., very young children, those with severe infections and those with recurrent infections," said the study's lead author, Dr. Jonathan C. Craig, a professor of clinical epidemiology at the School of Public Health at the University of Sydney in Australia.

Results of the study are published in the Oct. 29 issue of the New England Journal of Medicine.

Urinary tract infections (UTIs) are very common in children. According to the study, 2 percent of boys and 8 percent of girls will have at least one UTI by the time they're 7 years old. Although often a mild infection, UTIs can be serious, with as many as 5 percent of children with one of these infections developing some type of kidney damage.

And that kidney damage can be long-lasting, according to Dr. Alejandro Hoberman, of the Children's Hospital of Pittsburgh, who authored an accompanying editorial in the journal.

"Some children have a condition known as vesicoureteral reflux, which with a urinary tract infection can lead to renal scarring, which can eventually lead to high blood pressure, the pregnancy complication preeclampsia and even kidney problems," Hoberman explained.

Craig's study included children with varying degrees of vesicoureteral reflux, which means urine backs up from the bladder into the kidney, as well as children without this condition. However, all of the children included in the study had had at least one symptomatic UTI.

The median age of the children at the start of the study was 14 months, and they were recruited from four centers in Australia. Just under two-thirds of the children were girls.

Half of the children (288) were randomly selected to receive the antibiotic combination preventively for 12 months, while the other youngsters received a placebo for 12 months.

The finding that 13 percent of the children receiving antibiotics developed a UTI during the study period versus 19 percent of those on placebo means that 14 children have to be treated with antibiotics to prevent one UTI from occurring, according to the study.

There were no statistically significant differences in the rates of adverse events in either group.

"This study is a welcome addition to the literature. It was a larger sample of children and had a control group with placebo, but there were only modest treatment effects. I think it's probably not a one-size-fits-all approach. There may still be subgroups of children [like those with reflux] who may benefit more," said Hoberman.

But, he added, "I'm not ready to completely discount antimicrobial prophylaxis yet. Let's not throw the baby out with the bathwater."

Craig said he believes the modest reduction in urinary tract infections with preventive antibiotic use outweighs the potential risks, such as the possible development of antibiotic-resistant bacteria.

More Information

To learn more about urinary tract infections in children, visit the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.



SOURCES: Jonathan C. Craig, M.B.Ch.B., Ph.D., professor of clinical epidemiology, School of Public Health, University of Sydney, Australia; Alejandro Hoberman, M.D., chief, division of general academic pediatrics, professor of pediatrics, and Jack L. Paradise M.D. Endowed Professor of Pediatric Research, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pa.; Oct. 29, 2009 New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. News of Declining Cancer Deaths Underscores the Power of Preventive Screening
2. More Women Choosing Preventive Double Mastectomy
3. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
4. HSA Plans are Covering Preventive Care on a First-Dollar Basis
5. US Preventive Medicine(R) Says Study on Heart Disease-related Deaths Demonstrates Need for Preventive Medical Care
6. U.S. Preventive Medicine to Expand into England with iHealth UK Ltd.
7. New Study: Screening for Problem Drinking is One of the Most Cost-Effective Clinical Preventive Services
8. U.S. Preventive Medicine(R) Predicts Robust Growth Ahead
9. Co-Pays Contribute to Drop in Preventive Care
10. American College of Preventive Medicine calls on ABC to cancel Eli Stone episode
11. Caregiver Magazine Urges Preventive Measures Against Wandering, Falls, Abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Military Connection friend ... entry to the JFK Virgin Atlantic lounge. , Bensko is no stranger to ... years ago, Bensko dedicated her life to supporting our wounded veterans. A world-class photographer, ...
(Date:6/23/2017)... , ... June 23, 2017 , ... ... Cancer Conference from Sept. 18 to 20. , The two-day conference is focused ... with the goal of improving patients’ lives and eliminating racial breast cancer-related disparities. ...
(Date:6/23/2017)... , ... June 23, 2017 , ... American Farmer, will ... series, which is slated to air fourth quarter 2017. American Farmer airs Tuesdays at ... Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking ...
(Date:6/23/2017)... ... 2017 , ... Radabaugh & Associates, a locally owned firm ... in North Central West Virginia, is embarking on a cooperative charity drive with ... the region. , The Stepping Stones organization offers a series of personal development ...
(Date:6/22/2017)... ... , ... Groove Ring is excited to announce they've partnered with Olympic runner ... and all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the ... From the rock face to the auto shop, Groove Ring is the world's first ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... The Cincinnati location of ... (NYSE: DPLO), has been awarded a Top Workplaces 2017 ... Results are based on an employee survey administered by WorkplaceDynamics, ... improvement. The survey measures several aspects of workplace culture, including ... ...
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
Breaking Medicine Technology: