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Prevention Is Key Research Goal for Premature Babies, Scientists Say
Date:2/10/2010

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Medical problems, such as preeclampsia, which is extremely high blood pressure in the mother, or fetal distress, do not fully explain the increase of induced deliveries, which often result in late preterm births, birth between 32 and 36 weeks gestation.  

"The decision to induce delivery in order to improve fetal viability must be balanced by recognition of the need to minimize the impairments that arise from preterm birth," the authors wrote. "Making this decision will remain a challenge for practitioners, because inducing delivery – by whatever method – before full term has adverse consequences for the newborn, even when it happens close to term."

Family history of preterm birth, stress, race, infection, inflammation and genetics do appear to play a role.  One of every three preterm births occurs to a mother who has an infection in her uterus, but may have no symptoms. Recent research has shown that the genes of the mother seem to make the greatest contribution to preterm birth risk, and genes in the fetus may also play a role.

The New England Journal of Medicine review article is a summary of a three-day symposium held in December 2008, entitled "Preventing Prematurity: Establishing a Network for Innovation and Discovery." It was cosponsored by the Burroughs Wellcome Fund and the March of Dimes and brought together the top investigators in preterm birth prevention research.

The authors note in their article that technological advances allow clinicians to save premature infants from death and some complications by treating the consequences of prematurity. However, "prevention is what is needed, and current research is being directed toward reaching this goal," the authors wrote.

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SOURCE March of Dimes
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