Navigation Links
Preventing toxic shock syndrome and other severe diseases

A researcher at The University of Western Ontario has received over $603,000 from the Canadian Institutes of Health Research (CIHR) to investigate how and why a group of bacterial toxins leads to the development of toxic shock syndrome and other serious diseases. John McCormick is an associate professor in the Department of Microbiology and Immunology at the Schulich School of Medicine & Dentistry, and a scientist with the Lawson Health Research Institute. His research is one of 18 projects at Western and Lawson to receive new CIHR operating grants totaling more than $9.55 million.

"We are looking at how these superantigen toxins bind to proteins on the surface of white blood cells. This binding causes the over-activation of the immune system which can result in the patient developing shock," says McCormick. The bacteria that produce these toxins include Streptococcus pyogenes (responsible for flesh-eating disease) and Staphylococcus aureus, including methicillin-resistant S. aureus, also known as the "MRSA" superbug.

"A patient can have a localized infection, for example, a staph infection in their toe, and that bacteria will release toxins which will go systemic, all through the body, even though the infection hasn't spread. The infection can be treated with antibiotics, but that won't have any affect on the toxins," explains McCormick. "By understanding how these toxins work, we can look at developing drug inhibitors that will target and neutralize the toxins."

On the flip side, McCormick believes these toxins could be utilized to fight cancer. "We know these toxins cause potent activation of the immune system, so if we could engineer them to bind only to cancer cells, we could get the immune system to destroy the cancer. That's a long-term goal we have."


Contact: Kathy Wallis
519-661-2111 x81136
University of Western Ontario

Page: 1

Related medicine news :

1. Blood-flow detector software show promise in preventing brain damage
2. Preventing variceal bleeding
3. OSHA Issues Draft Ergonomics Guidelines on Preventing Musculoskeletal Injuries in Shipyards
4. Preventing or reducing enlarged heart decreases risk of heart failure
5. Pill Equals Injection in Preventing Clots After Hip Replacement
6. Treating obstructive sleep apnea, preventing heart attacks and strokes
7. Preventing lung scarring may extend lives of lung cancer patients
8. Preventing or reducing enlarged heart may decrease risk for diabetes
9. Study shows drug effective in treating, preventing breast cancer
10. Good Hygiene Is Key to Preventing MRSA
11. Preventing Cancer, This Week on Your Cancer Today(TM)
Post Your Comments:
(Date:11/29/2015)... ... 30, 2015 , ... The Cyber Monday deal is a deep 40% or more discount on ... get gifts for the skin care lover in your circle. Each Christmas, Sublime Beauty ... year, the 3 serums are staples: Collagen, Retinol and Hyaluronic Serums. , Stocking stuffers like ...
(Date:11/29/2015)... (PRWEB) , ... November 29, 2015 , ... While conventional ... kneeling or provide ready access to exercise weights. Fortunately, an inventor from Uniontown, Pa., ... THE TOMMY WALKER to enhance the benefits of a standard walker to improve the ...
(Date:11/29/2015)... ... November 29, 2015 , ... Effective immediately, every single IguanaMed scrub style ... Black Friday Target is offering a “Buy One Scrub Set, Get the 2nd Scrub ... to purchase IguanaMed at a discounted price. , IguanaMed’s mission is to ...
(Date:11/28/2015)... , ... November 28, 2015 , ... Safe storage for ... of two inventors, one from Lakewood, New Jersey and the other from Bradley Beach, ... patent-pending PROTECTOR to save the expense of having to replace NuvaRings more often than ...
(Date:11/28/2015)... ... , ... Pixel Film Studios is back again with ProPanel: Pulse . ... endless. Users have full control over angle of view, speed method, start point, end ... to get heads to turn. , ProPanel: Pulse offers fully customizable pulsating shape masks, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Research and Markets ( ) has announced ... Outlook to 2019 - Rise in Cardiac Disorders and Growing ... to their offering. Boston ... scientific and others. --> The market ... Boston scientific and others. ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... Global Cell Surface Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... European Therapeutic Drug Monitoring (TDM) Market: ... Intelligence, Emerging Opportunities"  report to their ... has announced the addition of the  ...
Breaking Medicine Technology: