Navigation Links
Preventing toxic shock syndrome and other severe diseases
Date:7/30/2009

A researcher at The University of Western Ontario has received over $603,000 from the Canadian Institutes of Health Research (CIHR) to investigate how and why a group of bacterial toxins leads to the development of toxic shock syndrome and other serious diseases. John McCormick is an associate professor in the Department of Microbiology and Immunology at the Schulich School of Medicine & Dentistry, and a scientist with the Lawson Health Research Institute. His research is one of 18 projects at Western and Lawson to receive new CIHR operating grants totaling more than $9.55 million.

"We are looking at how these superantigen toxins bind to proteins on the surface of white blood cells. This binding causes the over-activation of the immune system which can result in the patient developing shock," says McCormick. The bacteria that produce these toxins include Streptococcus pyogenes (responsible for flesh-eating disease) and Staphylococcus aureus, including methicillin-resistant S. aureus, also known as the "MRSA" superbug.

"A patient can have a localized infection, for example, a staph infection in their toe, and that bacteria will release toxins which will go systemic, all through the body, even though the infection hasn't spread. The infection can be treated with antibiotics, but that won't have any affect on the toxins," explains McCormick. "By understanding how these toxins work, we can look at developing drug inhibitors that will target and neutralize the toxins."

On the flip side, McCormick believes these toxins could be utilized to fight cancer. "We know these toxins cause potent activation of the immune system, so if we could engineer them to bind only to cancer cells, we could get the immune system to destroy the cancer. That's a long-term goal we have."


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Page: 1

Related medicine news :

1. Blood-flow detector software show promise in preventing brain damage
2. Preventing variceal bleeding
3. OSHA Issues Draft Ergonomics Guidelines on Preventing Musculoskeletal Injuries in Shipyards
4. Preventing or reducing enlarged heart decreases risk of heart failure
5. Pill Equals Injection in Preventing Clots After Hip Replacement
6. Treating obstructive sleep apnea, preventing heart attacks and strokes
7. Preventing lung scarring may extend lives of lung cancer patients
8. Preventing or reducing enlarged heart may decrease risk for diabetes
9. Study shows drug effective in treating, preventing breast cancer
10. Good Hygiene Is Key to Preventing MRSA
11. Preventing Cancer, This Week on Your Cancer Today(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and its ... cancer. , Gary D. Radine, who recently retired as president and CEO of Delta ... 2015 CEO of the Year , helped lead the effort to raise funds ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating ... a significant number of women and men with eating disorders report a history ... best predicts the development of an eating disorder. , At the 2016 ...
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published data from ... type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels ... in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua Rosenthal, PhD, Chief Scientific ... can use newly released government data on populations and physicians to better calculate ... capture the value they create to succeed in new economic models for value ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... only four states in the U.S. require dental technicians to be certified or ... the dental industry, NADL created the “What’s In Your Mouth?” campaign to inform ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... report "Global Anti-Bacterial Drugs Market Assessment & Forecast: 2015 - 2019" ... North America continued to lead global anti-bacterial ... into revenues worth US$ 16,907.3 million. North ... , Latin America , Middle-East ... market is inclined towards North America and ...
(Date:2/9/2016)... BETHESDA, Md. , Feb. 9, 2016 /PRNewswire-USNewswire/ ... community for pharmaceutical professionals developing and manufacturing sterile ... Global Sterile Manufacturing Regulatory Guidance Comparison – With ... regulatory guidance documents issued by the U.S. FDA, ... World Health Organization. --> ...
(Date:2/8/2016)... Feb.8, 2016 Alzheimer Diagnostic Tests - ... Medical Devices sector report , "Alzheimer Diagnostic ... an overview of Alzheimer Diagnostic Tests currently in ... on the pipeline products with comparative analysis of ... report reviews major players involved in the pipeline ...
Breaking Medicine Technology: