Navigation Links
Preventing lung scarring may extend lives of lung cancer patients
Date:10/29/2007

Researchers have found that using a special type of drug called a pharmaceutical monoclonal antibody to block the integrin beta6-TGF-beta pathway prevents a serious side effect of radiation therapy for lung cancer patients pulmonary fibrosis (scarring of the lungs), thereby extending patients lives and improving their quality of life, according to a study presented at the Plenary I session on October 29, 2007, at the American Society for Therapeutic Radiology and Oncologys 49th Annual Meeting in Los Angeles.

The toxicity of pulmonary fibrosis limits the amount of the radiation dose that can be safely given to patients, said Simon Cheng, M.D., Ph.D., an author of the study and a radiation oncologist at New York University Medical Center in New York. These study results may lead to more effective radiation therapies for advanced lung cancer, which is the leading cause of cancer deaths in the U.S.

More than 50 percent of patients receiving radiation therapy for advanced lung cancer develop radiation-induced lung fibrosis, a painful side effect that can affect patients quality of life and, in some cases, can be fatal. Pulmonary (lung) fibrosis involves inflammation and scarring of the lungs causing patients to feel short of breath, have a chronic dry cough, feel fatigue and pain in the chest, and suffer loss of appetite and weight loss. Over time, fibrosis causes the air sacs of the lungs to be replaced by scar tissue, causing difficulty breathing and an irreversible loss of the tissues ability to transfer oxygen into the bloodstream.

This study involved mice treated with a 14 Gy single dose of radiation to the lungs. Researchers wanted to determine if using an antibody to block integrin beta6 (a specific activator of the transforming growth factor (TGF-beta) signaling pathway), could prevent the onset of radiation-induced pulmonary fibrosis. The study shows that mice that were given integrin beta6 monoclonal antibodies did not develop radiation-induced lung fibrosis, while the control group of mice developed the lung condition.

Fibrosis is a very serious side effect that often keeps doctors from giving patients a full dose of radiation for fear that the serious problems caused by fibrosis will outweigh the good done by the radiation. If further studies conclude that this drug can indeed prevent fibrosis in lung cancer patients, I believe researchers are a huge step closer to curing this disease, said Dr. Cheng.


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-431-2332
American Society for Therapeutic Radiology and Oncology
Source:Eurekalert

Related medicine news :

1. Preventing mental decline in the aged
2. Preventing white coat hypertension
3. Green tea beneficial in preventing osteoarthritis
4. Preventing Childhood Deaths
5. Preventing Vision Loss
6. Preventing Vision Loss
7. Preventing Colorectal Cancer
8. Preventing Prostate Cancer
9. Lycopene Can Help In Preventing Prostate Cancer
10. Heart Drug Also Effective In Preventing Specific Causes Of Death
11. Preventing cavities in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... December 06, 2016 , ... TopConsumerReviews.com recently gave a best-in-class 5 star rating ... Scooters give freedom to people who need help getting around. For some, advancing age ... long period of rehabilitation after an illness or accident. There is a wide variety ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... magazine’s 2017 Training Top 125 for their industry leading training methods that engage ... recognizes USA as among the global elite in employer-sponsored training and development programs. ...
(Date:12/5/2016)... ... 2016 , ... Edward Buckingham MD , and the ... the newest Sciton laser in January 2017. The Halo is the first and ... wavelengths for exceptional results. Outperforming more traditional lasers, the innovative Halo automatically customizes ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... ... announced it has been featured in SuperbCrew magazine, a leading online tech news ... world. This interview, now featured on SuperbCrew.com, explores the state of enterprise mobility ...
(Date:12/5/2016)... Novato, CA (PRWEB) , ... December 05, 2016 ... ... company, has extended its partnership with leading global lifestyle design firm kathy ireland® ... , Worldwise® and kathy ireland® Worldwide entered into an exclusive licensing agreement three ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016 Sanovas, Inc., ... accelerator, announced today the launch of its wholly owned subsidiary, ... Logo - http://photos.prnewswire.com/prnh/20161202/445250LOGO   Logo - http://photos.prnewswire.com/prnh/20161202/445251LOGO   ... ... There are ...
(Date:12/5/2016)... -- Wellbridge Health and Gateway Health proudly announce a dynamic collaboration ... Medicaid plan members with specific high risk needs. ... this group of consumers, Wellbridge combines technology and population expertise ... into members, daily behaviors and lifestyle. ... , , ...
(Date:12/5/2016)... 5, 2016  Recently Zymo Research announced an ... known as Horvath,s Clock. Based on this technology, ... service to academic and biopharma scientific researchers to ... other than sperm. The service quantifies ... age versus chronological age following drug treatments and ...
Breaking Medicine Technology: