Navigation Links
Preventing eggs' death from chemotherapy
Date:6/17/2013

CHICAGO --- Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function.

Scientists achieved this in female mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin.

The results will be presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco.

"This research advances the efforts to find a medical treatment to protect the fertility and hormone health of girls and young women during cancer treatment, " said So-Youn Kim, the lead investigator and a postdoctoral fellow in the laboratory of Teresa Woodruff, chief of fertility preservation at Northwestern University Feinberg School of Medicine.

Adding imatinib mesylate to the drug cisplatin blocks the action of a protein that triggers a cascade of events resulting in death of the immature eggs. Kim discovered the protein that triggers the oocyte's ultimate death is Tap63.

Previous research suggested that imatinib is a fertility-protecting drug against cisplatin, but reports of the drug's effectiveness have been contradictory, Kim said. Her research confirms its effectiveness in an animal model.

She is currently testing imatinib with other chemotherapy agents to see if it also protects fertility in combination with them.

To demonstrate that imatinib protects oocytes against cisplatin, Kim and colleagues cultured ovaries (containing the immature eggs) from five-day-old mice with imatinib and cisplatin for 96 hours. The ovaries were then placed in a kidney capsule in the host mice to keep the ovaries alive. Two weeks later, the immature eggs were still alive. The imatinib did not block cisplatin-induced DNA damage, but Kim believes the eggs may recover and repair the damage over time.

"Previous reports have shown that chemotherapy and radiation-treated oocytes are able to recover from DNA damage," Kim said.


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces Uncomplicated New Diet Plans for Men to Aid in Preventing Certain Cancers Due to Excess Weight
2. Dr. Robin Fleck Shares Tips on Preventing Sunburn
3. Aspirin Equals Pricier Blood Thinner for Preventing Clots: Study
4. Likelihood of Spousal HPV Oral Infection, Predictors of Melanoma and Throat Cancer, Preventing Cancer Readmissions
5. Spousal oral HPV, predictors of melanoma and throat cancer, preventing cancer readmissions
6. As Summer Approaches, Experts Offer Tips on Preventing Skin Cancer
7. Heart Attack Preventing Drug, Plavix, Poses Continued Risk While Bristol-Myers Squibb Extends the Rights to Others for Generic OTC Versions
8. Protein complex may play role in preventing many forms of cancer, Stanford study shows
9. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
10. Six Tips for Preventing Tooth Erosion in Kids from Family Tree Dental Group
11. Strides Made in Preventing Cancer, But Challenges Remain: Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... British Columbia (PRWEB) , ... June 28, 2017 ... ... CNZCF) (FSE: ZEON) is pleased to announce that a two year study conducted ... the Company's Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As ...
(Date:6/28/2017)... ... June 28, 2017 , ... Doner Financial, ... regions access to insurance assistance and financial planning services, is announcing the commencement ... families in the region facing financial crisis. , Matthew 25: Ministries (M25M) is ...
(Date:6/28/2017)... ... June 28, 2017 , ... The Dianne Michael ... greater Cincinnati metropolitan area, is teaming up with the local chapter of the ... receiving treatment in nearby hospitals. , Ronald McDonald House of Greater Cincinnati, one ...
(Date:6/27/2017)... ... 27, 2017 , ... Nearly 70 percent of consumers now ... by the American Society for Dermatologic Surgery (ASDS). , The ... considering a cosmetic medical procedure has doubled since 2013. , “Cosmetic procedures continue ...
(Date:6/27/2017)... ... 2017 , ... Harbour , a DAO (decentralized autonomous organization) that harnesses ... released their technical specifications . , 2017 has seen an explosion of token ... determining which offerings will garner the greatest ROI. Dean Eigenmann, Co-founder and CEO of ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... -- The Cincinnati location of Diplomat ... DPLO), has been awarded a Top Workplaces 2017 ... are based on an employee survey administered by WorkplaceDynamics, LLC, ... The survey measures several aspects of workplace culture, including alignment, ... ...
(Date:5/30/2017)... , May 30, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... data solutions, today announced that it will be presenting at the ... 8:00 AM PT. Erez Raphael , CEO, of DarioHealth will ... conference will be held on June 6th & 7th, 2017 at ... in the small / micro-cap space. ...
(Date:5/26/2017)... BARBARA, Calif. , May 25, 2017  In ... United States , Direct Relief is working with ... overdose-reversing Naloxone available at no cost to community health ... other nonprofit providers nationwide. "Pfizer has ... access to medicines and ensuring patient safety through educational ...
Breaking Medicine Technology: