Navigation Links
Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s
Date:5/30/2008

The prevalence of pre-cancerous masses in the colon is the same for average-risk patients who are 40 to 49 years of age and those who are 50 to 59 years of age, reports a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

Currently, standard protocol recommends screening patients age 50 and over for colon cancer based on the increasing incidence of colon cancer at that age. Because observational studies have shown that it takes a decade for pre-cancerous growths, or adenomas, to develop and progress to cancer, the increase in colon cancer prevalence in the over-50 age group, in fact, may be the result of undetected adenomas that were present in the individuals in their 40s.

Investigating this hypothesis, a team of researchers, led by Drs. Alfred I. Neugut and Andrew Rundle from Columbia University Medical Center, compared colonoscopy results, broken down by age group. Analyzing records from a centralized digital medical record system provided by EHE International, the team reviewed 553 screening colonoscopies for patients ages 40 to 49 and 352 screening colonoscopies for patients ages 50 to 59. Individuals who could be deemed "high-risk" because of a family history of colon cancer, a personal history of inflammatory bowel disease or any malignancy other than skin cancer were excluded from the sample.

Of the records reviewed, in the 40 to 49 age group, 79 patients, or 14 percent, had one or more adenoma. Similarly, the 50 to 59 age group had 56 patients, or 16 percent, with one or more adenoma.

"Our results support the theory that adenomas, which later may lead to cancer, form at an age earlier than we screen for today," said Alfred I. Neugut, MD, PhD, professor of medicine and epidemiology at Columbia University Medical Center and head of cancer prevention and control for the Herbert Irving Comprehensive Cancer Center of Columbia University Medical Center and New York-Presbyterian Hospital. "With this information in hand, it is logical to think that if we were to recommend screening for colon cancer at age 40, we may be able to decrease its prevalence even further and save more people from having to battle the disease."

Though the number of adenomas was relatively similar in the two age groups, there was a doubling in the prevalence of abnormal cell growth, or advanced neoplasia, in the 50 to 59 age group versus the 40 to 49 age group. While not statistically significant, in the 40 to 49 age group, 11 patients, or 2 percent, had an advanced neoplasm, and in the 50 to 59 age group, 13 patients, or 4 percent, had an advanced neoplasm.

"What this implies is that while the number of pre-cancerous growths is very similar in both age groups, there is a progression toward cancer in older patients," said Andrew Rundle, DrPH, assistant professor of epidemiology at Columbia's Mailman School of Public Health. "Abnormal cell growth is a warning sign of cancer, so the fact that there's an increase in advanced neoplasia in the older age group is in line with the increased colon cancer incidence we see in individuals over the age of 50. Detecting adenomas when patients are in their 40s could mean that we are able to drastically lower the prevalence of colorectal cancer. Additional studies need to be done to look specifically at this possibility and the cost-benefit of beginning screening at an earlier age."

EHE International, which sponsored the research, has been providing comprehensive physical exams for 95 years, and since 2002 has been using a digital electronic medical record system that can provide anonymous, de-identified data for biomedical research. "We are thrilled that the medical record data that we have accumulated over the years through our business can be used to conduct such important research and promote the greater good," said Deborah McKeever, president of EHE International.

Only one prior study has investigated the prevalence of colorectal adenomas in average-risk individuals aged 40 to 49 years in the U.S., and it reports very similar findings: an adenoma prevalence of 11 percent in the age group.


'/>"/>

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. APIC Launches First National C. Difficile Prevalence Study
2. APIC launches first national C. difficile prevalence study
3. Painful Sex in Women: Studies Show High Prevalence, but New Hope
4. The prevalence and impact of arthritis and other rheumatic conditions in the United States
5. Miscarriage myths persist despite prevalence of medical information
6. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
7. Asymptomatic peripheral artery disease prevalence is rising
8. A low prevalence of H pylori in HIV-positive patients
9. Prevalence of COPD Greater Than Thought
10. Incidental adrenal masses commonly seen on CT are usually benign; no follow-up needed
11. Follow-up imaging of benign-appearing incidental adrenal masses is unnecessary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF Orthopaedic Center ... Houston Area. The new location is located at 2255 E. Mossy Oaks Rd., Suite ... This newest location will provide patients living in the north Houston area (The Woodlands, ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy ... 960 Gruene Road in Building 2. The clinic is the group’s second in New ... says opening the company’s second New Braunfels location brings things full circle for the ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... The IoT ... and WiFi connectivity are making a huge impact on businesses and individual consumers alike. ... estimates the IoT will have a value anywhere from $4 trillion to $11 trillion ...
(Date:3/23/2017)... ... ... of adults are unaware of the dangers that infectious bacteria play in mouth disease, while ... a day that dentists recommend. The ramifications of improper oral upkeep go far beyond bad ... 164 million hours of work each year due to dental issues. That is why Mediaplanet ...
(Date:3/23/2017)... ... ... March is National Kidney Month – the perfect time to pause and ... health. Every day, two kidneys filter about 120 to 150 quarts of blood. Put ... waste, regulating fluid levels and blood pressure, supporting bone health and promoting red blood ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the ... Strategies" report to their offering. ... Pain Management in the ... their physical pain, emphasizing consumer survey analysis, including trends over ... adults who have selected illnesses/conditions strongly associated with physical pain ...
(Date:3/24/2017)... 24, 2017 ShangPharma, a leading ... cost-effective drug development and discovery services, technology, ... industry, announced today the intent for a ... be consolidating the Contract Research Organizations (CRO) ... ChemPartner. These entities include ChemPartner Shanghai, ChemPartner ...
(Date:3/24/2017)... , Mar. 24, 2017 Research and Markets ... Pipeline Analysis, 2016" report to their offering. ... The IPF pipeline is very strong with a ... Merck & Co., Inc., Biogen and Sanofi are involved in the development ... of which one is in Phase III stage, 15 are in Phase ...
Breaking Medicine Technology: