Navigation Links
Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists
Date:4/12/2010

LIVERPOOL, UK 12 April 2010: Scientists at the University of Liverpool have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa.

Their research has found that, in adults with HIV, new African Salmonellae can cause severe disease by invading cells in the blood and bone marrow, where they can hide away, allowing them to evolve into more dangerous, multi-drug resistant strains over time. This is made possible by the loss of immune cells that occurs in HIV which renders the body vulnerable to attack.

In Europe and the US, Salmonella normally causes diarrhoea and is rarely fatal, but in Africa, the new multi-drug resistant strains exploit vulnerable children and adults, causing severe infections that are difficult to treat and leading to death in one in four cases.

Previous work at the University of Liverpool in collaboration with the Wellcome Trust Sanger Institute, showed that new epidemic human strains of Salmonella are unique to Africa and have evolved to give a greater potential to cause serious disease. Researchers showed the strains, which were previously non-invasive, have now developed genetic similarities to the Salmonella bug that causes Typhoid Fever. This is significant because as well as being antibiotic resistant, their behaviour is likely to be intrinsically more invasive and aggressive than typical strains found in the US and Europe. This evolution has probably been driven by the context of the HIV epidemic.

The fact that the cells can persist inside cells in the blood and bone marrow confirms that these strains are behaving in a new and highly invasive fashion. It means that the infections are difficult to treat, and often persist and recur. This in turn means that conditions continue to be favourable for more bacterial adaptation, and for the evolution of more antibiotic resistance.

Dr Melita Gordon, Senior Lecturer and Consultant in Gastroenterology in the University of Liverpool, who carried out the work in partnership with Liverpool School of Tropical Medicine and the Malawi-Liverpool Wellcome Trust Major Overseas Unit, said: "This suggests that the high rate of HIV and other diseases that affect the immune system in Africa has provided an environmental niche in which new, more dangerous strains of Salmonella have been able to emerge.

"We are now studying ways in which these multi-drug resistant infections can be treated better without encouraging the emergence of newer forms of resistance to antibiotics. We should also be able to use the new genetic markers to track and understand the spread and habits of Salmonella in Africa much more effectively."


'/>"/>

Contact: Kate Spark
kate.spark@liv.ac.uk
44-151-794-2247
University of Liverpool
Source:Eurekalert

Related medicine news :

1. Shape of Barretts epithelium effects prevalence of erosive esophagitis
2. First blinded study of venous insufficiency prevalence in MS shows promising results
3. New study reveals prevalence of cyberbullying and its psychological impact on nonheterosexual youth
4. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
5. Study Suggests High HIV Rate Among African Teens
6. Black Journalists Group to Hold Conference on African-American Health and Health Care Disparities
7. AMP Receives Grant From the Bill & Melinda Gates Foundation to Support Cholera Surveillance in Africa
8. LeapFrog Invests $6M in AllLife, Innovative African HIV and Diabetes Insurer
9. New USAID Mission Director for South Africa Sworn In
10. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
11. Most maternal deaths in sub-Saharan Africa could be avoided
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... ... Dr. Robert Mondavi, one of the dentists in Torrance , is now ... as more patients are discovering the many different ways they can change and improve ... to them and which ones might work for their smiles. , “One of ...
(Date:4/29/2016)... ... April 29, 2016 , ... Reltok Nasal Products proudly announces that Boston ... and neck/ear, nose and throat specialty, has added the KOTLER NASAL AIRWAY™ to its ... is a newly patented safety device secured by nasal surgeons onto the floor ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the market ... funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... and accelerate its technology and product roadmap. , “Jvion is experiencing ...
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored ... satisfaction survey, earning them second place for Tampa’s Best Places to Work. They were ... “This is a great accomplishment for our team,” says RMS Human Resources Manager Irene ...
(Date:4/29/2016)... Newport Beach, CA (PRWEB) , ... April 29, 2016 , ... ... Dr. Jane L. Frederick, Dr. Sanaz Ghazal, and Dr. Daniel A. Potter -- are ... the Society for Assisted Reproductive Technology (SART). In April, SART published the ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... Tie-up with Government hospitals as ... to save newborns   Fortis La Femme, ... collaboration with Breast Milk Foundation (BMF), a non-profit organization within ... Bank, ,Amaara, in Delhi-NCR today. This non-profit centre recognizes that ... and should be available to babies deprived of mother,s milk.  ...
(Date:4/27/2016)... April 27, 2016 Oasmia ... developer of a new generation of drugs within ... survival results for Paclical/Apealea in the Phase III ... with epithelial ovarian cancer. These preliminary results showed ... combination with carboplatin versus Taxol in combination with ...
(Date:4/26/2016)... , April 26, 2016 Diplomat Pharmacy, ... of Jennifer Hagerman , Pharm D., to Vice ... growing role at Diplomat, Hagerman will continue to lead ... company that delivers custom education and training to Diplomat ... specialty pharmacy industry. Diplomat University also houses the quality ...
Breaking Medicine Technology: