Navigation Links
Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists
Date:4/12/2010

LIVERPOOL, UK 12 April 2010: Scientists at the University of Liverpool have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa.

Their research has found that, in adults with HIV, new African Salmonellae can cause severe disease by invading cells in the blood and bone marrow, where they can hide away, allowing them to evolve into more dangerous, multi-drug resistant strains over time. This is made possible by the loss of immune cells that occurs in HIV which renders the body vulnerable to attack.

In Europe and the US, Salmonella normally causes diarrhoea and is rarely fatal, but in Africa, the new multi-drug resistant strains exploit vulnerable children and adults, causing severe infections that are difficult to treat and leading to death in one in four cases.

Previous work at the University of Liverpool in collaboration with the Wellcome Trust Sanger Institute, showed that new epidemic human strains of Salmonella are unique to Africa and have evolved to give a greater potential to cause serious disease. Researchers showed the strains, which were previously non-invasive, have now developed genetic similarities to the Salmonella bug that causes Typhoid Fever. This is significant because as well as being antibiotic resistant, their behaviour is likely to be intrinsically more invasive and aggressive than typical strains found in the US and Europe. This evolution has probably been driven by the context of the HIV epidemic.

The fact that the cells can persist inside cells in the blood and bone marrow confirms that these strains are behaving in a new and highly invasive fashion. It means that the infections are difficult to treat, and often persist and recur. This in turn means that conditions continue to be favourable for more bacterial adaptation, and for the evolution of more antibiotic resistance.

Dr Melita Gordon, Senior Lecturer and Consultant in Gastroenterology in the University of Liverpool, who carried out the work in partnership with Liverpool School of Tropical Medicine and the Malawi-Liverpool Wellcome Trust Major Overseas Unit, said: "This suggests that the high rate of HIV and other diseases that affect the immune system in Africa has provided an environmental niche in which new, more dangerous strains of Salmonella have been able to emerge.

"We are now studying ways in which these multi-drug resistant infections can be treated better without encouraging the emergence of newer forms of resistance to antibiotics. We should also be able to use the new genetic markers to track and understand the spread and habits of Salmonella in Africa much more effectively."


'/>"/>

Contact: Kate Spark
kate.spark@liv.ac.uk
44-151-794-2247
University of Liverpool
Source:Eurekalert

Related medicine news :

1. Shape of Barretts epithelium effects prevalence of erosive esophagitis
2. First blinded study of venous insufficiency prevalence in MS shows promising results
3. New study reveals prevalence of cyberbullying and its psychological impact on nonheterosexual youth
4. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
5. Study Suggests High HIV Rate Among African Teens
6. Black Journalists Group to Hold Conference on African-American Health and Health Care Disparities
7. AMP Receives Grant From the Bill & Melinda Gates Foundation to Support Cholera Surveillance in Africa
8. LeapFrog Invests $6M in AllLife, Innovative African HIV and Diabetes Insurer
9. New USAID Mission Director for South Africa Sworn In
10. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
11. Most maternal deaths in sub-Saharan Africa could be avoided
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... ... Sun City is the place to be on March 3rd to learn about the latest ... hosting this educational seminar from 5:30 p.m. – 7:00 p.m. Exciting advancements will be presented ... addition, prizes will be given away and light refreshments will be served. , As ...
(Date:2/13/2016)... ... ... Many individuals looking to lead a healthy lifestyle have decreased carbohydrate consumption and increased ... has delved into this niche allowing those giving up their beloved pasta a chance ... grams of protein and only 7 grams of carbohydrates per 50 gram serving--a ratio ...
(Date:2/13/2016)... ... February 13, 2016 , ... In its newly released ... visualization technology should be used to ensure patient safety when placing an IV ... Standards mandate the use of vein visualization technology in patients with difficult venous ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or ... groom themselves to perfection, go out of their way to be romantic, and may ... take a look at any online dating profile. , A recent study from ...
(Date:2/12/2016)... San Antonio, TX (PRWEB) , ... February 12, 2016 , ... ... of love, as expressed in Blue SKies Buddha, the biography of Rama - Dr. ... in fact a love story, the love of a Buddhist teacher for teaching and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Stem cells are primitive cells ... self-renewal and the capacity to differentiate into mature cell ... as the first mouse embryonic stem cells were derived ... 1995 that the first culturing of embryonic stem cells ... not produced until 2006 As a result of these ...
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. ... saving and improving the lives of pets, today announced ... of the New Animal Drug Application (NADA) for Zimeta™ ... field study (KB0120) of Zimeta for the control of ... Company. --> --> ...
(Date:2/11/2016)... 2016   Health 2.0 , the premiere showcase ... announced today " 10 Year Global Retrospective ", a ... the past ten years.   --> ... 2.0 has served as the preeminent thought-leader in the ... of technologies, companies, innovators, and patient-activists through an array ...
Breaking Medicine Technology: