Navigation Links
Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans
Date:2/25/2010

The maximal standardized uptake value (called SUVmax) measured from FDG PET readings taken from the primary tumor in head and neck squamous cell carcinoma patients before treatment is a strong predictor of disease-specific survival, overall survival and disease-free survival, while pretreatment SUVmax for lymphodenopathy is strongly associated with distant metastasis, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM. Since the head and neck area of the body is very rich in lymphatic drainage, it is common for head and neck cancer patients to also have lympahdenopathy, which is an enlarged neck lymph node. Researchers from the University Hospitals Case Medical Center in Cleveland and the University of Nevada at Reno School of Public health in Reno, Nev., conducted a retrospective study of 295 patients treated with IMRT, with 177 having FDG PET before treatment and having a record of SUVmax for either their primary tumor and/or lymphadenopathy (SUV-LN). "The findings of this study show that we may use SUV before treatment to personalize treatment approaches for some head and neck cancer patients since SUV has been shown to be associated with treatment outcomes," Min Yao, M.D., Ph.D., lead author of the study and a radiation oncologist at University Hospitals Case Medical Center in Cleveland, said. "Higher SUV may mean more aggressive treatment approaches, and since we now know that SUV of the lymph node is associated with distant metastasis, those patients with high SUV-LN may need more aggressive systemic chemotherapy." The three-year distant metastasis-free survival and disease specific survival rates for all patients were both 78.8 percent and the disease free survival and overall survival rates were 63.95 and 67.4 percent, respectively. SUVmax of the primary tumor was found to be significantly associated with disease specific survival and overall survival and strongly associated with disease free survival. SUV-LN was significantly associated with distant metastasis, with the distant metastasis-free survival rate being 82.1 percent at three years when the SUV-LN was less than 11.3 and 63.4 percent when the SUV-LN was greater than 11.3.


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-431-2332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Patients pretreatment quality of life can predict overall lung cancer survival
2. Increased HAART coverage associated with 50 percent drop
3. New research shows emotional impact of low sexual desire and associated distress
4. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
5. Certain pain medications do not appear to be associated with skin cancer risk
6. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
7. Glaucoma medications may be associated with reduced risk of death over 4-year period
8. Prolactin blocks oncogene associated with poor prognosis in breast cancer
9. FDA Announces Safety Risk Associated with HIV Drug
10. Benefits outweigh risks associated with newborn screening for disorder
11. NIH takes step to assess any possible risk associated with low-dose radiation exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... Marne, Michigan (PRWEB) , ... May 02, 2016 ... ... for addiction at a residential inpatient rehabilitation center can find some useful information ... substance abuse located in Central Michigan. This video, which can be viewed on ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... As directed ... Association of Pennsylvania (HAP) issues its full support to allow certified nurse practitioners (CNP) ... supervision after they have worked under such supervision for three years and 3,600 hours. ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Civilian Corps of the U.S. Army Medical ... that care for its uniformed service members, the retired service members, their families and ... 6th through May 12th National Nurses Week. It acknowledges the hard work and dedication ...
(Date:5/2/2016)... ... May 02, 2016 , ... “Engineering Bubbles,” an oil painting submitted by ... Art Forum held recently at the Annual Meeting in Los Angeles. The first annual ... members and Annual Meeting attendees. , “Through art I hope to educate ...
(Date:5/2/2016)... ... May 02, 2016 , ... WestHarbor Growth Partners, a ... the release of Grow Healthy Vending’s newly revamped brand campaign. Grow Healthy ... healthy vending providers in North America with locations across the United States as ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... , May 2, 2016 ... reach USD 11.1 billion by 2024, according to ... Inc. Major drivers of the sonography market include ... and government recommendations for periodic ultrasound screenings of ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) High ...
(Date:4/29/2016)... , April 29, 2016 ... Directeur Financier Sanofi, leader ... publie ses résultats pour le premier ... Groupe, Jérôme Contamine, commente les résultats ... les perspectives pour le reste de ...
(Date:4/28/2016)... NEW YORK , April 28, 2016 /PRNewswire/ ... will notably complement the company,s valve repair and ... the move also places Abbott more firmly into ... one of the fastest growing device areas, with ... to its recent report,  Advanced Remote Patient ...
Breaking Medicine Technology: