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Press briefings at International Microbicides Conference May 22-25
Date:5/17/2010

aim at HIV from all possible angles. Results of new studies could indicate the direction of future clinical trials, including results from the first primate study evaluating an integrase inhibitor as a topical microbicide.

Participants: Walid Heneine, Ph.D., U.S. Centers for Disease Control and Prevention; Robin Shattock, Ph.D., St. George's, University of London, U.K. Moderator: Jim Turpin, Ph.D., Division of AIDS, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health

MONDAY, May 24
11:15-12 p.m.

Microbicides that Do More than Gel: Vaginal Rings, Tablets and Films

As alternatives to microbicide gels that must be used every day or at the time of sex, researchers are looking at other types of formulations that may be more acceptable for women to use, and for certain drugs or drug combinations, may be more optimal vehicles for their delivery. Unlike a gel, an intravaginal ring, for example, feasibly could provide protection for a month at a time. In fact, one research group has developed an intravaginal ring formulated with two anti-HIV drugs dapivirine and maraviroc that it found can deliver therapeutic levels of both drugs for up to 30 days. Other researchers have developed a vaginal film smaller than a stick of gum and as thin as a sheet of paper. The idea is that as the film would melt away drug would be dispersed to cells to protect against HIV. Laboratory tests of a similar approach an almond-shaped vaginal tablet found it can dissolve quickly yet still deliver sustained levels of anti-HIV drugs over several hours.

Participants: Andrew Loxley, Ph.D., Particle Sciences, Inc., Bethlehem, Pa.; Sanjay Garg, Ph.D., School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; Anthony Ham, Ph.D., ImQuest BioSciences, Frederick, Md. Moderator: Joseph Romano, Ph.D., International Partnership for Microbicides, Silver Spring, Md.'/>"/>

Contact: Lisa Rossi
rossil@upmc.edu
412-916-3315
Microbicides 2010 (International Conference on Microbicides)
Source:Eurekalert

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