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Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
Date:4/10/2012

n Institutional Review Board approved database. We identified 921 children with hearing loss from 2000 to present. Patients who passed NHS with subsequent hearing loss were included.


Perioperative Dexamethasone and The Risk of Bleeding in Pediatric Tonsillectomy: A Prospective, Randomized, Double Blind Trial
Speaker: Thomas Gallagher, DO
Date: Saturday, April 21, 2012
Time: 8:00 8:07am

San Diego, CA One-time perioperative dexamethasone administration prior to tonsillectomy is equivalent to saline placebo with regards to risk of post-operative bleeding in the pediatric population.

"The purpose of this study was to determine if perioperative dexamethasone affected the post-tonsillectomy hemorrhage rate in children," said study author Thomas Gallagher, DO.

This was a multicenter, prospective, randomized, double-blind, placebo-controlled study of 306 patients ages 3-18 undergoing tonsillectomy for either obstructive sleep apnea or recurrent tonsillitis. The chief outcome measure was defined as whether or not there was bleeding in the post-operative period significant enough to return to the operating room for control. A non-inferiority statistical design was chosen in order to demonstrate whether dexamethasone has equivalent bleeding rates compared with placebo. The non-inferiority margin was set at 5% based on a review of the literature as well as in accordance with our historical tonsillectomy bleeding rate. The study group received a one-time, perioperative dose of dexamethasone 0.5mg/kg (max 20mg). The placebo group received volume equivalent 0.9% saline. The post-operative time period was 14 days. All investigators performed tonsillectomy in a standardized fashion using electrocautery on similar power settings.

The summary of results show post-operative bleeding was stratified into three levels of severity. There were 153 children enrolled in each arm. The mean age of the chil
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Contact: Mary Stewart
mstewart@entnet.org
703-535-3762
American Academy of Otolaryngology - Head and Neck Surgery
Source:Eurekalert

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