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Presentations at AHA expand on clinical utility of deCODE's DNA-based tests
Date:11/7/2008

ntile LDL cholesterol and is as common, with about 25 percent of the general population carrying the high-risk markers.

In the Sunday morning session, deCODE will review the latest findings on these 9p21 variants in MI and other cardiovascular conditions for which these SNPs are risk factors, including abdominal aortic aneurysm and intracranial aneurysm. The session will also summarize the results of a UK clinical study showing that the accuracy of MI risk prediction is increased by measuring these 9p21 variants in addition to conventional risk factors. In two Tuesday sessions, Christie M. Ballantyne, M.D., and his colleagues from Baylor College of Medicine will discuss the clinical utility of measuring the 9p21 markers in addition to conventional risk factors for MI in the context of the ARIC study.

The 4q25 variants and risk of atrial fibrillation and stroke In 2007, deCODE discovered two SNPs on chromosome 4q25 that double the risk of atrial fibrillation (AF), and launched its deCODE AF test to detect these variants. Given that AF is underdiagnosed, one principal purpose of this test is to enable the identification of people at higher risk and to monitor them more intensively and to put those who exhibit AF on appropriate medication.

At this year's AHA, deCODE and independent groups will present data from studies that expand the understanding of how deCODE AF can contribute to better clinical practice. deCODE's original discovery of the 4q25 SNPs was replicated and validated in several European and U.S. case-control cohorts. Since then, the company has published findings that the SNPs in deCODE AF also confer risk of ischemic stroke, with highest risk for cardioembolic stroke. At AHA the company will discuss the implications of linking these markers not only with risk of AF, but also to risk of stroke and non-cardiogenic stroke. One implication is that AF appears to cause an even larger proportion of stroke than originally thought.
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Contact: Amy Speak
Amy.Speak@porternovelli.com
617-480-2708
deCODE genetics
Source:Eurekalert

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