Navigation Links
Preparing Small Doses of Medication From Syringes Called Risky
Date:1/24/2011

MONDAY, Jan. 24 (HealthDay News) -- Preparing small doses of medications from syringes can be inaccurate and lead to dangerous dosing errors for infants and small children, warns a new study.

The problem is that small doses of potent drugs for young patients are often prepared from stock of less than 0.1 millileter (mL) in size, but the equipment does not permit the accurate measurement of volumes that small, explained study author Dr. Christopher Parshuram, of the University of Toronto.

And medications that most often require small doses include powerful narcotics and sedatives such as morphine, lorazepam and fentanyl, as well as immunosuppressants, noted Parshuram, who works in the Department of Pediatrics at The Hospital for Sick Children and directs Pediatric Patient Safety Research at the University of Toronto Center for Patient Safety.

It's a Catch-22, he and his colleagues acknowledge. "The safe administration of medications requires formulations that permit accurate preparation and administration, but current equipment does not permit the accurate measurement of volumes less than 0.1 mL," said Parshuram in a Canadian Medical Association Journal news release.

In both hypothetical and clinical studies, he and his colleagues looked at 71,218 intravenous doses given to 1,531 infants and children admitted to an intensive care unit in 2006. Of those doses, 7.4 percent of the children and babies needed preparations of less than 0.1 mL of stock solution, and 17.5 percent needed preparations of less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," the researchers wrote.

"Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions," they added. "The clinical [consequences] of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

Since the preparation of small doses of medication is common in pediatric hospitals across North America, there is a need to review preparation methods, regulatory requirements and manufacturing processes, the researchers concluded.

The study appears in the current issue of the Canadian Medical Association Journal.

More information

The U.S. Food and Drug Administration has more about giving medications to children.

-- Robert Preidt

SOURCE: Canadian Medical Association Journal, news release, Jan. 24, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MIT China joint venture is preparing a major commercial launch in July 2010
2. Small Spreads of Breast Cancer May Not Affect Survival
3. Small molecules may prevent ebola infection
4. MIT neuroscientists explain Proustian effect of small details attached to big memories
5. Deadliest Cancer Getting Smaller Chunk of Research Dollars
6. Small molecule may disarm enemy of cancer-fighting p53
7. Small assist device used in emergency case as twin, heart booster pumps for first time in US
8. Unexpectedly small effects of mutations in bacteria bring new perspectives
9. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
10. Small particles show big promise in beating unpleasant odors
11. Small business success spotlighted by USDA at conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preparing Small Doses of Medication From Syringes Called Risky
(Date:6/23/2017)... ... June 23, 2017 , ... Dr. ... New York, has recently begun offering three new minimally invasive procedures to patients ... procedures and reducing downtime, Dr. Rubinstein is excited to bring microneedling, microneedling facials, ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has recently highlighted Dr. ... come up with a proprietary technique that he calls the AuraLyft Facelift. ... For all ages, patients can expect to look refreshed, rejuvenated, and revitalized. , ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent Care opened its ... facility overall and marks the urgent care center's eighth location in Miami-Dade county. , ... Falls shopping mall. The new clinic offers a wide array of services ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus in ... 9 am to 3 pm to present to graduate students exciting new and innovative ... original curriculum project led by The Health Improvement Service of the Western Health & ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & Associates, ... families and business owners in North Central West Virginia, is embarking on a ... differently abled residents in the region. , The Stepping Stones organization offers a ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... BELL, Pa. , June 1, 2017 ... (PRN) and Veterinarian Recommended Solutions (VRS), and KD Pharma ... investment in Nutriceutical Holdings by KD Pharma Group. KD ... Holdings with the option to acquire the entire company. ... partner in KD. They are committed to growing the ...
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/26/2017)... May 25, 2017  In response to the opioid ... Direct Relief is working with Pfizer to make up ... no cost to community health centers, free and charitable ... "Pfizer has a long-standing commitment to ... ensuring patient safety through educational activities," said Caroline ...
Breaking Medicine Technology: