Navigation Links
Preparing Small Doses of Medication From Syringes Called Risky
Date:1/24/2011

MONDAY, Jan. 24 (HealthDay News) -- Preparing small doses of medications from syringes can be inaccurate and lead to dangerous dosing errors for infants and small children, warns a new study.

The problem is that small doses of potent drugs for young patients are often prepared from stock of less than 0.1 millileter (mL) in size, but the equipment does not permit the accurate measurement of volumes that small, explained study author Dr. Christopher Parshuram, of the University of Toronto.

And medications that most often require small doses include powerful narcotics and sedatives such as morphine, lorazepam and fentanyl, as well as immunosuppressants, noted Parshuram, who works in the Department of Pediatrics at The Hospital for Sick Children and directs Pediatric Patient Safety Research at the University of Toronto Center for Patient Safety.

It's a Catch-22, he and his colleagues acknowledge. "The safe administration of medications requires formulations that permit accurate preparation and administration, but current equipment does not permit the accurate measurement of volumes less than 0.1 mL," said Parshuram in a Canadian Medical Association Journal news release.

In both hypothetical and clinical studies, he and his colleagues looked at 71,218 intravenous doses given to 1,531 infants and children admitted to an intensive care unit in 2006. Of those doses, 7.4 percent of the children and babies needed preparations of less than 0.1 mL of stock solution, and 17.5 percent needed preparations of less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," the researchers wrote.

"Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions," they added. "The clinical [consequences] of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

Since the preparation of small doses of medication is common in pediatric hospitals across North America, there is a need to review preparation methods, regulatory requirements and manufacturing processes, the researchers concluded.

The study appears in the current issue of the Canadian Medical Association Journal.

More information

The U.S. Food and Drug Administration has more about giving medications to children.

-- Robert Preidt

SOURCE: Canadian Medical Association Journal, news release, Jan. 24, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MIT China joint venture is preparing a major commercial launch in July 2010
2. Small Spreads of Breast Cancer May Not Affect Survival
3. Small molecules may prevent ebola infection
4. MIT neuroscientists explain Proustian effect of small details attached to big memories
5. Deadliest Cancer Getting Smaller Chunk of Research Dollars
6. Small molecule may disarm enemy of cancer-fighting p53
7. Small assist device used in emergency case as twin, heart booster pumps for first time in US
8. Unexpectedly small effects of mutations in bacteria bring new perspectives
9. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
10. Small particles show big promise in beating unpleasant odors
11. Small business success spotlighted by USDA at conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preparing Small Doses of Medication From Syringes Called Risky
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
Breaking Medicine Technology: