Navigation Links
Preparing Small Doses of Medication From Syringes Called Risky
Date:1/24/2011

MONDAY, Jan. 24 (HealthDay News) -- Preparing small doses of medications from syringes can be inaccurate and lead to dangerous dosing errors for infants and small children, warns a new study.

The problem is that small doses of potent drugs for young patients are often prepared from stock of less than 0.1 millileter (mL) in size, but the equipment does not permit the accurate measurement of volumes that small, explained study author Dr. Christopher Parshuram, of the University of Toronto.

And medications that most often require small doses include powerful narcotics and sedatives such as morphine, lorazepam and fentanyl, as well as immunosuppressants, noted Parshuram, who works in the Department of Pediatrics at The Hospital for Sick Children and directs Pediatric Patient Safety Research at the University of Toronto Center for Patient Safety.

It's a Catch-22, he and his colleagues acknowledge. "The safe administration of medications requires formulations that permit accurate preparation and administration, but current equipment does not permit the accurate measurement of volumes less than 0.1 mL," said Parshuram in a Canadian Medical Association Journal news release.

In both hypothetical and clinical studies, he and his colleagues looked at 71,218 intravenous doses given to 1,531 infants and children admitted to an intensive care unit in 2006. Of those doses, 7.4 percent of the children and babies needed preparations of less than 0.1 mL of stock solution, and 17.5 percent needed preparations of less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," the researchers wrote.

"Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions," they added. "The clinical [consequences] of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

Since the preparation of small doses of medication is common in pediatric hospitals across North America, there is a need to review preparation methods, regulatory requirements and manufacturing processes, the researchers concluded.

The study appears in the current issue of the Canadian Medical Association Journal.

More information

The U.S. Food and Drug Administration has more about giving medications to children.

-- Robert Preidt

SOURCE: Canadian Medical Association Journal, news release, Jan. 24, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MIT China joint venture is preparing a major commercial launch in July 2010
2. Small Spreads of Breast Cancer May Not Affect Survival
3. Small molecules may prevent ebola infection
4. MIT neuroscientists explain Proustian effect of small details attached to big memories
5. Deadliest Cancer Getting Smaller Chunk of Research Dollars
6. Small molecule may disarm enemy of cancer-fighting p53
7. Small assist device used in emergency case as twin, heart booster pumps for first time in US
8. Unexpectedly small effects of mutations in bacteria bring new perspectives
9. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
10. Small particles show big promise in beating unpleasant odors
11. Small business success spotlighted by USDA at conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preparing Small Doses of Medication From Syringes Called Risky
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many of ... beholder, according to experts who offered insights and commentary in the current issue of ... full issue, click here . , For the American Society of Clinical Oncology ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
Breaking Medicine Technology: