Navigation Links
Preparing Small Doses of Medication From Syringes Called Risky
Date:1/24/2011

MONDAY, Jan. 24 (HealthDay News) -- Preparing small doses of medications from syringes can be inaccurate and lead to dangerous dosing errors for infants and small children, warns a new study.

The problem is that small doses of potent drugs for young patients are often prepared from stock of less than 0.1 millileter (mL) in size, but the equipment does not permit the accurate measurement of volumes that small, explained study author Dr. Christopher Parshuram, of the University of Toronto.

And medications that most often require small doses include powerful narcotics and sedatives such as morphine, lorazepam and fentanyl, as well as immunosuppressants, noted Parshuram, who works in the Department of Pediatrics at The Hospital for Sick Children and directs Pediatric Patient Safety Research at the University of Toronto Center for Patient Safety.

It's a Catch-22, he and his colleagues acknowledge. "The safe administration of medications requires formulations that permit accurate preparation and administration, but current equipment does not permit the accurate measurement of volumes less than 0.1 mL," said Parshuram in a Canadian Medical Association Journal news release.

In both hypothetical and clinical studies, he and his colleagues looked at 71,218 intravenous doses given to 1,531 infants and children admitted to an intensive care unit in 2006. Of those doses, 7.4 percent of the children and babies needed preparations of less than 0.1 mL of stock solution, and 17.5 percent needed preparations of less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," the researchers wrote.

"Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions," they added. "The clinical [consequences] of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

Since the preparation of small doses of medication is common in pediatric hospitals across North America, there is a need to review preparation methods, regulatory requirements and manufacturing processes, the researchers concluded.

The study appears in the current issue of the Canadian Medical Association Journal.

More information

The U.S. Food and Drug Administration has more about giving medications to children.

-- Robert Preidt

SOURCE: Canadian Medical Association Journal, news release, Jan. 24, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MIT China joint venture is preparing a major commercial launch in July 2010
2. Small Spreads of Breast Cancer May Not Affect Survival
3. Small molecules may prevent ebola infection
4. MIT neuroscientists explain Proustian effect of small details attached to big memories
5. Deadliest Cancer Getting Smaller Chunk of Research Dollars
6. Small molecule may disarm enemy of cancer-fighting p53
7. Small assist device used in emergency case as twin, heart booster pumps for first time in US
8. Unexpectedly small effects of mutations in bacteria bring new perspectives
9. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
10. Small particles show big promise in beating unpleasant odors
11. Small business success spotlighted by USDA at conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preparing Small Doses of Medication From Syringes Called Risky
(Date:12/5/2016)... ... , ... “Epilepsy Awareness,” which can be found at the ... about epilepsy, bearing down on the social stigma and lack of public education ... within their lifetime. With such a large percentage of people affected, it’s critically ...
(Date:12/5/2016)... ... December 05, 2016 , ... Physicians Education Resource®, LLC (PER®) ... on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma, on February 24, 2017. ... to have Amy E. Herman present at this year’s conference, her unprecedented knowledge ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... ... gender, and geographic lines. The goal of Castlewood Treatment Centers has always been ... accessible to as many people as possible. In that spirit, Castlewood has ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one of New York ... participated in the 36th Annual Cutting Edge Aesthetic Symposium at the Waldorf Astoria in ... that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for his expertise in ...
(Date:12/5/2016)... ... 2016 , ... Sideline Products is a Southern York County Pennsylvania-based premier designer ... and the horse. Smaller saddles can pinch and irritate the horse creating safety issues ... properly fitted western saddle so it does not impact the comfort or performance of ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... BOCA RATON, Fla. , Dec. 5, ... Commercialization of Public Research (the Florida Institute) ... agreement SegAna, LLC, an Orlando ... Central Florida. The Florida Institute supports new company ... funding gaps for companies spinning out of Florida-based universities ...
(Date:12/5/2016)... Dec. 5, 2016  Breckenridge Pharmaceutical, Inc. announced ... marketing agreement with development and manufacturing partner Gland ... the terms of this agreement, Breckenridge will market ... the United States . The ... ANDA. The products cover a wide range of ...
(Date:12/5/2016)... 2016  Sharn Anesthesia Inc. announced today that it ... partner for Salter Labs.  The company also received the ... of outstanding sales performance. Salter Labs is ... care, including the market gold standard ECO 2 ... of the Parker Flex-Tip® Endotracheal Tube, which is a ...
Breaking Medicine Technology: