Navigation Links
Preoperative aspirin therapy can benefit cardiac surgery patients
Date:12/5/2011

SACRAMENTO, Calif. -- Aspirin taken within five days of cardiac surgery is associated with a significant decrease in the risk of major postoperative complications, including renal failure, a lengthy intensive care unit stay and even early death (30-day mortality), according to a study by researchers at Thomas Jefferson University and UC Davis Medical Center set to appear in the journal Annals of Surgery.

According to the study's authors, the findings are significant because despite remarkable progress in cardiac surgery, the number of major complications from cardiac surgery remains high.

"Therapies targeted to prevent or reduce major complications associated with cardiac surgery have been few and ineffective so far," said Jianzhong Sun, an anesthesiologist at Thomas Jefferson University and lead author of the study. "These complications are significant and costly both for the public health and the quality of patient life."

The study team evaluated the impact of preoperative aspirin on major outcomes in adults (total 4,256 consecutive patients) who had cardiac surgery -- mostly coronary artery bypass graft or valve surgery -- at Thomas Jefferson University Hospital or UC Davis Medical Center between 2001 and 2009. Among 2,868 patients who met the inclusion criteria, 1,923 took aspirin (about 81 to 325 mg daily) at least once within five days preceding their surgery versus 945 not taking aspirin (non-aspirin therapy).

The outcomes showed that preoperative aspirin therapy (vs. non-aspirin) is associated with a significant decrease in the risk for 30-day mortality, major adverse cardiocerebral events, postoperative renal failure and average time spent in the intensive care unit.

Beneficial effects of preoperative aspirin use found in the current study "are in line with our previous findings and findings from early postoperative aspirin studies," wrote Sun and colleagues in their paper.

"We know that aspirin can be lifesaving for patients who have experienced heart attacks," said Nilas Young, chief of cardiothoracic surgery at UC Davis and a study co-author. "Now we know that this simple intervention can do the same for patients who undergo certain coronary surgeries. This outcome could lead to new preoperative treatment standards in cardiac medicine."

The researchers acknowledge that bleeding remains a concern with preoperative aspirin therapy. However, they said, in the current era of cardiac surgery, the potential for bleeding may be avoided by using antifibrinolytic therapy, which prevents the breakdown of clotting factors in the blood, and/or a low dose of aspirin.

"Overall, the outcome benefits provided by preoperative aspirin therapy may override its possible risk of excess bleeding in patients undergoing cardiac surgery. Nonetheless, further studies are certainly needed to examine this potential side effect carefully," Sun and colleagues wrote.

Added Zvi Grunwald, chair of anesthesiology at Jefferson, "While we are excited that the study clearly showed that preoperative use of aspirin significantly reduced major complications and mortality in patients undergoing cardiac surgery, we do urge further study before recommending aspirin for cardiac surgery patients prior to surgery."


'/>"/>
Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9111
University of California - Davis Health System
Source:Eurekalert

Related medicine news :

1. Preoperative/neoadjuvant therapy in pancreatic cancer
2. Preoperative MRI assists in surgical planning and helps spare erectile function after RALP
3. Can eGFR be a routine preoperative renal function test?
4. Response to preoperative therapy may predict survival in pancreatic cancer patients
5. Preoperative breast MRI suggests high cancer yield
6. Aspirin May Boost Breast Cancer Survival
7. Cardiologists Comment on Aspirin Versus Resveratrol
8. Aspirin Alone Works Best to Prevent Clots a Year After Stenting
9. Aspirin May Increase Risk of Crohns Disease
10. Experts Advise At-Risk Diabetics to Begin Daily Aspirin Later
11. Aspirin recommendations changed for many younger diabetic patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... , ... December 06, 2016 , ... ... availability of the newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol ... audit protocols to understand the scope of their EHS regulatory obligations and rapidly ...
(Date:12/6/2016)... ... 06, 2016 , ... U.S. Security Associates (USA) was named ... their industry leading training methods that engage their associates and link their achievements ... elite in employer-sponsored training and development programs. , “The 2017 Training Top 125 ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... its latest transitional care facility – Avamere Transitional Care of Puget Sound ... foot short-term, post-acute health care center will provide patients recovering from illness or ...
(Date:12/5/2016)... St. Petersburg, Fla. (PRWEB) , ... December 05, 2016 , ... ... effects concussions have on the growing brains of young athletes. Over the course of ... to the head through unique mouth guards. The mouth guards, equipped with special sensors, ...
(Date:12/5/2016)... ... December 05, 2016 , ... Physicians Education Resource®, ... International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma, on February ... are honored to have Amy E. Herman present at this year’s conference, her ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Research and Markets has announced the addition of ... & Biochemical Research, Disease Diagnostics), End User (Academic & Research Institutes, ... to their offering. ... , The western blotting market ... 574.8 Million in 2016, growing at a CAGR of 4.9%. ...
(Date:12/5/2016)... 5, 2016   BIOTRONIK today announced the ... study evaluates the safety and feasibility of performing the ... setting. BioMonitor 2 is an insertable cardiac ... placed underneath a patient,s skin to help physicians accurately ... fibrillation is a leading cause of stroke and heart ...
(Date:12/5/2016)... Dec. 5, 2016  CVS Health, the nation,s largest ... a perfect score of 100 percent on the Corporate ... CEI is an annual national benchmarking survey and report ... administered by the Human Rights Campaign Foundation. ... that our colleagues, customers and suppliers bring to CVS ...
Breaking Medicine Technology: