Navigation Links
Preoperative aspirin therapy can benefit cardiac surgery patients

SACRAMENTO, Calif. -- Aspirin taken within five days of cardiac surgery is associated with a significant decrease in the risk of major postoperative complications, including renal failure, a lengthy intensive care unit stay and even early death (30-day mortality), according to a study by researchers at Thomas Jefferson University and UC Davis Medical Center set to appear in the journal Annals of Surgery.

According to the study's authors, the findings are significant because despite remarkable progress in cardiac surgery, the number of major complications from cardiac surgery remains high.

"Therapies targeted to prevent or reduce major complications associated with cardiac surgery have been few and ineffective so far," said Jianzhong Sun, an anesthesiologist at Thomas Jefferson University and lead author of the study. "These complications are significant and costly both for the public health and the quality of patient life."

The study team evaluated the impact of preoperative aspirin on major outcomes in adults (total 4,256 consecutive patients) who had cardiac surgery -- mostly coronary artery bypass graft or valve surgery -- at Thomas Jefferson University Hospital or UC Davis Medical Center between 2001 and 2009. Among 2,868 patients who met the inclusion criteria, 1,923 took aspirin (about 81 to 325 mg daily) at least once within five days preceding their surgery versus 945 not taking aspirin (non-aspirin therapy).

The outcomes showed that preoperative aspirin therapy (vs. non-aspirin) is associated with a significant decrease in the risk for 30-day mortality, major adverse cardiocerebral events, postoperative renal failure and average time spent in the intensive care unit.

Beneficial effects of preoperative aspirin use found in the current study "are in line with our previous findings and findings from early postoperative aspirin studies," wrote Sun and colleagues in their paper.

"We know that aspirin can be lifesaving for patients who have experienced heart attacks," said Nilas Young, chief of cardiothoracic surgery at UC Davis and a study co-author. "Now we know that this simple intervention can do the same for patients who undergo certain coronary surgeries. This outcome could lead to new preoperative treatment standards in cardiac medicine."

The researchers acknowledge that bleeding remains a concern with preoperative aspirin therapy. However, they said, in the current era of cardiac surgery, the potential for bleeding may be avoided by using antifibrinolytic therapy, which prevents the breakdown of clotting factors in the blood, and/or a low dose of aspirin.

"Overall, the outcome benefits provided by preoperative aspirin therapy may override its possible risk of excess bleeding in patients undergoing cardiac surgery. Nonetheless, further studies are certainly needed to examine this potential side effect carefully," Sun and colleagues wrote.

Added Zvi Grunwald, chair of anesthesiology at Jefferson, "While we are excited that the study clearly showed that preoperative use of aspirin significantly reduced major complications and mortality in patients undergoing cardiac surgery, we do urge further study before recommending aspirin for cardiac surgery patients prior to surgery."

Contact: Karen Finney
University of California - Davis Health System

Related medicine news :

1. Preoperative/neoadjuvant therapy in pancreatic cancer
2. Preoperative MRI assists in surgical planning and helps spare erectile function after RALP
3. Can eGFR be a routine preoperative renal function test?
4. Response to preoperative therapy may predict survival in pancreatic cancer patients
5. Preoperative breast MRI suggests high cancer yield
6. Aspirin May Boost Breast Cancer Survival
7. Cardiologists Comment on Aspirin Versus Resveratrol
8. Aspirin Alone Works Best to Prevent Clots a Year After Stenting
9. Aspirin May Increase Risk of Crohns Disease
10. Experts Advise At-Risk Diabetics to Begin Daily Aspirin Later
11. Aspirin recommendations changed for many younger diabetic patients
Post Your Comments:
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is actively feeding the Frederick area economy by obtaining investment capital for emerging ... the past 2½ years that have already resulted in more than a million ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
Breaking Medicine Technology: