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Preoperative aspirin therapy can benefit cardiac surgery patients
Date:12/5/2011

SACRAMENTO, Calif. -- Aspirin taken within five days of cardiac surgery is associated with a significant decrease in the risk of major postoperative complications, including renal failure, a lengthy intensive care unit stay and even early death (30-day mortality), according to a study by researchers at Thomas Jefferson University and UC Davis Medical Center set to appear in the journal Annals of Surgery.

According to the study's authors, the findings are significant because despite remarkable progress in cardiac surgery, the number of major complications from cardiac surgery remains high.

"Therapies targeted to prevent or reduce major complications associated with cardiac surgery have been few and ineffective so far," said Jianzhong Sun, an anesthesiologist at Thomas Jefferson University and lead author of the study. "These complications are significant and costly both for the public health and the quality of patient life."

The study team evaluated the impact of preoperative aspirin on major outcomes in adults (total 4,256 consecutive patients) who had cardiac surgery -- mostly coronary artery bypass graft or valve surgery -- at Thomas Jefferson University Hospital or UC Davis Medical Center between 2001 and 2009. Among 2,868 patients who met the inclusion criteria, 1,923 took aspirin (about 81 to 325 mg daily) at least once within five days preceding their surgery versus 945 not taking aspirin (non-aspirin therapy).

The outcomes showed that preoperative aspirin therapy (vs. non-aspirin) is associated with a significant decrease in the risk for 30-day mortality, major adverse cardiocerebral events, postoperative renal failure and average time spent in the intensive care unit.

Beneficial effects of preoperative aspirin use found in the current study "are in line with our previous findings and findings from early postoperative aspirin studies," wrote Sun and colleagues in their paper.

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Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9111
University of California - Davis Health System
Source:Eurekalert

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