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Prenatal tests more informative using microarray technology, find GW researchers
Date:12/6/2012

ic or developmental disorders. It also identified additional abnormalities that were completely undetected by karyotyping.

"Particularly when a prenatal ultrasound has shown anomalies it becomes very important for parents to have an explanation. When the karyotype is normal, microarray analysis will provide additional information in 6 percent of cases. This diagnosis allows parents to plan for early intervention, especially in the case of autism spectrum and other neurodevelopmental disorders," said Ms. Zachary.

Use of microarray for analysis of prenatal samples has only been done in a few laboratories in the U.S. until recently, primarily because of high cost, the difficulty in developing protocols which achieve reliable success rates in DNA extraction from uncultured prenatal samples and the limited experience by genetic counselors and physicians in interpreting the results.

Dr. Thom is a research faculty member at the School of Public Health and Health Services. The Biostatistics Center is a research facility under the Office of the Vice President for Research and serves as a coordinating center for large scale multi-center clinical trials and epidemiologic studies. Its researchers participate in major medical research programs of national and international scope, frequently leading to major medical advances.


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Contact: Latarsha Gatlin
lgatlin@gwu.edu
202-994-5631
George Washington University
Source:Eurekalert

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