Navigation Links
Prenatal nicotine exposure may lead to ADHD in future generations

TALLAHASSEE, Fla. Prenatal exposure to nicotine could manifest as attention deficit hyperactivity disorder in children born a generation later, according to a new study by Florida State University College of Medicine researchers.

Professors Pradeep G. Bhide and Jinmin Zhu have found evidence that ADHD associated with nicotine can be passed across generations. In other words, your child's ADHD might be an environmentally induced health condition inherited from your grandmother, who may have smoked cigarettes during pregnancy a long time ago. And the fact that you never smoked may be irrelevant for your child's ADHD.

The researchers' findings are published in the current issue of The Journal of Neuroscience.

"What our research and other people's research is showing is that some of the changes in your genome whether induced by drugs or by experience may be permanent and you will transmit that to your offspring," said Bhide, chair of developmental neuroscience and director of the Center for Brain Repair at the College of Medicine.

Bhide and Zhu, assistant professor of biomedical sciences, used a mouse model to test the hypothesis that hyperactivity induced by prenatal nicotine exposure is transmitted from one generation to the next. Their data demonstrated that there is a transgenerational transmission via the maternal, but not the paternal, line of descent.

"Genes are constantly changing. Some are silenced and others are expressed, and that happens not only by hereditary mechanisms, but because of something in the environment or because of what we eat or what we see or what we hear," Bhide said. "So the genetic information that is transmitted to your offspring is qualitatively different than the information you got from your parents. This is how things change over time in the population."

Building on recent discoveries about how things like stress, fear or hormonal imbalance in one individual can be passed along to the next generation, Bhide and Zhu were curious about a proven link between prenatal nicotine exposure and hyperactivity in mice.

Their work at the Center for Brain Repair has included extensive research around ADHD, a neurobehavioral disorder affecting about 10 percent of children and 5 percent of adults in the United States. Researchers have struggled to produce a definitive scientific explanation for a spike in ADHD diagnoses in the last few decades.

"Some reports show up to a 40 percent increase in cases of ADHD in one generation, basically," Bhide said. "It cannot be because a mutation occurred; it takes several generations for that to happen."

One possible contributing factor, though unproven, is that the current spike in ADHD cases correlates in some manner to an increase in the number of women who smoked during pregnancy as cigarettes became fashionable in the United States around the time of World War II and in the decades that followed.

"Other research has shown a very high correlation between heavy smoking during pregnancy and the incidence of kids with ADHD," Bhide said.

"What's important about our study is that we are seeing that changes occurring in my grandparents' genome because of smoking during pregnancy are being passed to my child. So if my child had ADHD it might not matter that I did not have a disposition or that I never smoked."

Bhide cautions that the work, though conclusive, is based on a study in mice, which have served as a proxy for human phenotypes.

"It's not that every child born to a mother who smokes has ADHD, and it also isn't true that every person with ADHD will transmit the genetic material responsible," he said.

"But our work has opened up new possibilities. The next question is how does transmission to future generations happen? What is the mechanism? And the second question is, if the individual is treated successfully would that stop the transmission to future generations?"

Contact: Doug Carlson
Florida State University

Related medicine news :

1. Prenatal exposure to pollution especially dangerous for children with asthma
2. Prenatal exposure to common household chemical increases risk for childhood eczema, study says
3. Prenatal Exposure to Common Household Chemical Linked to Eczema
4. Prenatal maternal smoking associated with increased risk of adolescent obesity
5. Prenatal exposure to pesticide additive linked with childhood cough
6. Prenatal diagnosis of congenital heart disease increases maternal stress, depression, and anxiety
7. Illy Trieste Science Prize: Yuk Ming Dennis Lo awarded for non-invasive prenatal diagnosis
8. Documenting womens experiences with chromosome abnormalities found in new prenatal test
9. Prenatal tests more informative using microarray technology, find GW researchers
10. Prenatal Antidepressants Dont Raise Fetal, Infant Death Risk: Study
11. Prenatal inflammation linked to autism risk
Post Your Comments:
(Date:11/24/2015)... , ... November 24, 2015 , ... ... the Business Action on Health Awards, bestowed annually to the world’s best corporate-supported ... commended companies at Global Health Council’s Landscape Symposium held in Washington D.C and ...
(Date:11/24/2015)... ... 2015 , ... The OSHA Training Center at Chabot-Las ... in Northern California, is calling on retail employers to implement safety measures to ... volume of sales and shoppers rapidly expands, retailers are strongly encouraged to develop ...
(Date:11/24/2015)... ... , ... There’s nothing better than giving the gift of green this holiday ... , This year, gardens are popping up in the most unexpected places. A variety ... Gardens’ African Keyhole Garden Bed ($499) , Water conscious gardeners – and that should ...
(Date:11/24/2015)... ... November 24, 2015 , ... Wireless Analytics, an ... announced new 24-hour weekday support capability. The “all hours” offering was introduced ... international customers, and to enhance after-hours support available in the US. , Available ...
(Date:11/24/2015)... ... , ... Take the audience on a journey with TransFrame Cloud from Pixel Film ... images without ever setting a single keyframe in Final Cut Pro X. Design smooth and ... to change the angle and depth of field to create a unique viewing perspective. , ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015  Figure 1, a free mobile-first ... medical cases, has launched a new completely redesigned web ... version allows radiologists, who work primarily on a desktop, ... engage with its radiologist user base, Figure 1 is ... North America (RSNA) Annual Meeting. ...
(Date:11/24/2015)... , Nov. 24, 2015  Family Rentals, a ... announced the launch of their newly designed, mobile-responsive ... --> Logo ... --> --> Now, renting essential ... and vacation, just got a whole lot easier ...
(Date:11/24/2015)... -- The uptake of recently approved and pipeline premium products ... market growth to 2021, says GBI Research . ... for Type 1 Diabetes Mellitus (T1DM), will be a key driver of ... --> The uptake of recently approved and pipeline premium ... of market growth to 2021, says GBI Research ...
Breaking Medicine Technology: