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Prenatal exposure to maternal antibodies linked to autistic behaviors in offspring
Date:2/11/2008

y crosses the placenta as a protective agent for the growing fetus and newborn child. However, antibodies formed against ones own body (autoantibodies) are implicated in disorders such as lupus, multiple sclerosis and arthritis. The known links between IgG and the prenatal environment and autoimmune-mediated disorders is what originally persuaded Van de Water to test the potential role of fetal-brain-specific IgG in autism.

The presence of stereotypies is part of one major symptom category in addition to social deficits and language impairments of the autism diagnosis. Clinicians do not know for certain why children with autism tend to repeatedly, for instance, rock, flap their hands, twirl objects or walk on their toes. It has been surmised that the repetition might help reduce anxiety or could be related to damage in specific parts of the brain. This new research provides evidence that brain-directed antibodies in the immune systems of mothers may provide part of the answer.

If we confirm that these antibodies are a risk factor for autism, its possible that they could be removed through treatments much like those used for autoimmune and inflammatory diseases, said study lead author Martin, who is now an assistant professor in the Department of Psychology at Azusa Pacific University and was a postdoctoral fellow in the Amaral lab when the study was conducted. Its early in the research process to consider specific therapies, but it is clear that our result should lead to a much greater emphasis in autism science on immune system links to the disorder.


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Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

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