Navigation Links
Prenatal exposure to endocrine-disrupting chemicals linked to breast cancer
Date:5/21/2010

A study in mice reveals that prenatal exposure to endocrine-disrupting chemicals, like bisphenol-A (BPA) and diethylstilbestrol (DES), may program a fetus for life. Therefore, adult women who were exposed prenatally to BPA or DES could be at increased risk of breast cancer, according to a new study accepted for publication in Hormones & Cancer, a journal of The Endocrine Society.

Endocrine-disrupting chemicals are substances in the environment that interfere with hormone biosynthesis, metabolism or action resulting in adverse developmental, reproductive, neurological and immune effects in both humans and wildlife. These chemicals are designed, produced and marketed largely for specific industrial purposes.

"BPA is a weak estrogen and DES is a strong estrogen, yet our study shows both have a profound effect on gene expression in the mammary gland (breast) throughout life," said Hugh Taylor, MD, of the Yale University School of Medicine in New Haven, Conn. and lead author of the study. "All estrogens, even 'weak' ones can alter the development of the breast and ultimately place adult women who were exposed to them prenatally at risk of breast cancer."

In this study, researchers treated pregnant mice with BPA or DES and then looked at the offspring as adults. When the offspring reached adulthood, their mammary glands still produced higher levels of EZH2, a protein that plays a role in the regulation of all genes. Higher EZH2 levels are associated with an increased risk of breast cancer in humans.

"We have demonstrated a novel mechanism by which endocrine-disrupting chemicals regulate developmental programming in the breast," said Taylor. "This study generates important safety concerns about exposures to environmental endocrine disruptors such as BPA and suggests a potential need to monitor women exposed to these chemicals for the development of breast lesions as adults."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
2. Prenatal exposure to flame-retardant compounds affects neurodevelopment of young children
3. Good Parenting Triumphs Over Prenatal Stress
4. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
5. HAPPYBABY Unveils Partners Prenatal Instructional Yoga DVD
6. Prenatal Stress May Boost Babys Asthma Risk
7. Prenatal Healthcare Providers Inconsistent In Weight Gain Counseling
8. Exposure to prenatal smoking may lead to psychiatric problems
9. Babies Responses to Prenatal Stress Differ by Gender
10. Lead Exposure May Contribute to ADHD
11. NIH takes step to assess any possible risk associated with low-dose radiation exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
Breaking Medicine Technology: