Navigation Links
Prenatal exposure to endocrine-disrupting chemicals linked to breast cancer

A study in mice reveals that prenatal exposure to endocrine-disrupting chemicals, like bisphenol-A (BPA) and diethylstilbestrol (DES), may program a fetus for life. Therefore, adult women who were exposed prenatally to BPA or DES could be at increased risk of breast cancer, according to a new study accepted for publication in Hormones & Cancer, a journal of The Endocrine Society.

Endocrine-disrupting chemicals are substances in the environment that interfere with hormone biosynthesis, metabolism or action resulting in adverse developmental, reproductive, neurological and immune effects in both humans and wildlife. These chemicals are designed, produced and marketed largely for specific industrial purposes.

"BPA is a weak estrogen and DES is a strong estrogen, yet our study shows both have a profound effect on gene expression in the mammary gland (breast) throughout life," said Hugh Taylor, MD, of the Yale University School of Medicine in New Haven, Conn. and lead author of the study. "All estrogens, even 'weak' ones can alter the development of the breast and ultimately place adult women who were exposed to them prenatally at risk of breast cancer."

In this study, researchers treated pregnant mice with BPA or DES and then looked at the offspring as adults. When the offspring reached adulthood, their mammary glands still produced higher levels of EZH2, a protein that plays a role in the regulation of all genes. Higher EZH2 levels are associated with an increased risk of breast cancer in humans.

"We have demonstrated a novel mechanism by which endocrine-disrupting chemicals regulate developmental programming in the breast," said Taylor. "This study generates important safety concerns about exposures to environmental endocrine disruptors such as BPA and suggests a potential need to monitor women exposed to these chemicals for the development of breast lesions as adults."


Contact: Aaron Lohr
The Endocrine Society

Page: 1

Related medicine news :

1. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
2. Prenatal exposure to flame-retardant compounds affects neurodevelopment of young children
3. Good Parenting Triumphs Over Prenatal Stress
4. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
5. HAPPYBABY Unveils Partners Prenatal Instructional Yoga DVD
6. Prenatal Stress May Boost Babys Asthma Risk
7. Prenatal Healthcare Providers Inconsistent In Weight Gain Counseling
8. Exposure to prenatal smoking may lead to psychiatric problems
9. Babies Responses to Prenatal Stress Differ by Gender
10. Lead Exposure May Contribute to ADHD
11. NIH takes step to assess any possible risk associated with low-dose radiation exposure
Post Your Comments:
(Date:10/13/2015)... ... ... Sir Grout of Greater Boston donated an expansive, seven room tile and ... (RMHC®). This donation was made in an effort to give back to the local ... “We believe strongly in the Ronald McDonald House Charities, and they are truly a ...
(Date:10/13/2015)... , ... October 13, 2015 , ... "My friend's son ... fists into his infected cheeks," said an inventor from Platteville, Colo. "I came up ... problems." , He developed the UNTOUCHABLE to prevent a child from rubbing or scratching ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... pain management services, today announced its partnership with WPC Healthcare , a ... disparate systems and organizes the data into an aggregated data repository necessary to ...
(Date:10/13/2015)... ... , ... According to an article published October 5th by the ... lose weight with a bariatric procedure are much less likely to develop endometrial cancer, ... anywhere from 40 to 50 percent of all endometrial cancer cases are caused by ...
(Date:10/13/2015)... ... October 13, 2015 , ... Altec ... their sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits to take ... and NAVUG Summit are independent user conferences designed and led by users to ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015   Vigilant Biosciences, Inc. ("Vigilant"), a ... the early detection and intervention of cancer, announced today ... CEO, Matthew H.J. Kim , the Weaver H. ... entrepreneur who has made extraordinary contributions to the growth ... in the leadership of a company or institution. ...
(Date:10/13/2015)... Oct. 13, 2015 WuXi PharmaTech (Cayman) ... technology platform company serving the pharmaceutical, biotechnology, and ... launched a mobile version of OncoWuXi, the first ... access oncology models and data on the go.  ... at any time to identify relevant tumor models ...
(Date:10/13/2015)... , Oct. 13, 2015   Happy ... direct-to-consumer laboratory home testing kit for breast ... technologies provide an unparalleled, detailed assessment of ... milk—fats, proteins, carbs and key vitamins—all charted ... for personal health tracking.  In addition, Happy Vitals ...
Breaking Medicine Technology: