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Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
Date:4/20/2011

Researchers from the Columbia Center for Children's Environmental Health at the Mailman School of Public Health report evidence of a link between prenatal exposure to the insecticide chlorpyrifos and deficits in IQ and working memory at age seven. This is the first study to evaluate the neurotoxicity of prenatal chlorpyrifos exposure on cognitive development at the time of school entry. Findings are online in Environmental Health Perspectives.

Until banned for indoor residential use by the U.S. Environmental Protection Agency in 2001, chlorpyrifos, an organophosphate pesticide, was one of the most widely used insecticides for residential pest control. In a sample of 265 New York City minority children, born prior to the ban, the researchers found evidence that increases in the amount of chlorpyrifos in the babies' umbilical cord blood were associated with decreases in performance on a measure of cognitive functioning at age 7. Specifically, higher prenatal exposure was associated with lower scores on two different scales of the Wechsler Intelligence Scales for Children (WISC-IV). On average, for each standard deviation increase in chlorpyrifos exposure, the full-Scale IQ was reduced by 1.4% (0.94 to 1.8 points) and Working Memory was reduced by 2.8% (1.6 to 3.7 points). This means that those children who have exposures in the upper 25% of the exposure distribution will score, on average, 5.5% (or 5.3 points) lower on the test of Working memory, and 2.7% (or 2.7) points lower on Full-scale IQ, as compared to those children in the lowest quartile. Furthermore, the decline in test scores begins at the lowest exposures and continues downward with increasing exposure levels. This suggests no evidence of a threshold, below which exposures are completely safe.

The Columbia researchers had previously reported that, prior to the ban, chlorpyrifos was detected in 100% of personal and indoor air samples, and 70% of umbilical cord blood colle
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Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

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