Navigation Links
Prenatal Exposure to Traffic Pollution May Lead to Asthma
Date:2/16/2009

Environment can boost mutations in genes, study says

MONDAY, Feb. 16 (HealthDay News) -- Traffic pollution may cause genetic changes in the womb that increase a child's risk of developing asthma, say U.S. researchers who studied umbilical cord blood from New York City children.

They found evidence of a possible new biomarker -- an epigenetic alteration in the gene ACSL3 -- associated with prenatal exposure to polycyclic aromatic hydrocarbons (PAHs), which are created as byproducts of incomplete combustion of carbon-containing fuels such as gasoline.

PAH levels are high in heavy-traffic areas, and exposure to PAHs has been linked to such diseases as cancer and childhood asthma.

The findings, published in the Feb. 16 issue of the journal PLoS One, offer a potential clue for predicting environmentally-related asthma in children, particularly those born to mothers who live in high-traffic areas, said the researchers from the University of Cincinnati and Columbia University Mailman School of Public Health.

Epigenetic changes can disrupt the normal functioning of genes by affecting their expression but don't cause structural changes or mutations in the genes.

"Our data support the concept that environmental exposure can interact with genes during key developmental periods to trigger disease onset later in life, and that tissues are being reprogrammed to become abnormal later," the study's senior author, Shuk-mei Ho, chairwoman of UC's Department of Environmental Health and director of the Center for Environmental Genetics, said in news release.

If the findings are confirmed in future studies, changes in the ACSL3 gene could offer a new biomarker for early diagnosis of pollution-related asthma.

"Understanding early predictors of asthma is an important area of investigation because they represent potential clinical targets for intervention," study co-author Dr. Rachel Miller, director of the Columbia Center for Children's Environmental Health at the Mailman School of Public Health, said in the release.

More information

The American Lung Association has more about childhood asthma.



-- Robert Preidt



SOURCE: University of Cincinnati, news release, Feb. 13, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ther-Rx Corporation Issues Voluntary Nationwide Recall of Prescription Prenatal and Iron Supplements to Wholesale Level
2. ETHEX Corporation Issues Voluntary Nationwide Recall of Prescription Prenatal and Iron Supplements to Wholesale Level
3. Prenatal Nutrition, Postnatal Allergy Protection
4. Upsher-Smith Laboratories Launches Prenexa.com to Support Prenatal Nutrition and Health
5. First and Only Single Capsule Daily Rx Prenatal Vitamin With Plant-Based DHA Now Available
6. High levels of prenatal smoking exposure affect sleep patterns in preterm neonates
7. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
8. Prenatal drug exposure linked to sleep problems in children
9. Prenatal biochemical screening only detects half of chromosomal abnormalities
10. Mothers prenatal stress predisposes their babies to asthma and allergy
11. Expectant Moms Offered Free Prenatal Prescription Vitamins at D-FW Area Carnival, Minyard and Sackn Save Stores
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prenatal Exposure to Traffic Pollution May Lead to Asthma
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
Breaking Medicine Technology: