Navigation Links
Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease

able. Spleen

volumes had decreased by 40 percent among 11 patients with available

data at one year.

-- At six months, hemoglobin levels had increased from baseline by a mean

of 0.9 grams per deciliter of blood among 17 patients for whom data

were available. Hemoglobin levels had increased by 1.3 grams per

deciliter among 13 patients with available data at one year.

-- Platelet counts increased from baseline by a mean of 18 percent among

17 patients treated for six months and by 34 percent among 13 patients

with available data at one year.

-- Chitotriosidase levels decreased from baseline by a mean of 30 percent

at six months among 20 patients and by 50 percent among 12 patients

treated for one year. Chitotriosidase commonly serves as a biomarker

of Gaucher disease burden, allowing physicians to monitor patient

response to treatment.

These preliminary results are consistent with results observed for patients beginning enzyme replacement therapy.

The analysis showed that drug-related adverse events seen in the trial occurred in a small number of patients, were mild and transient in nature, and did not require any medical intervention. The drug-related adverse events were diarrhea, abdominal pain, tachycardia, and headache.

Genzyme is currently developing protocols for two Phase 3 trials that it expects to initiate early next year. One trial is expected to include untreated Gaucher patients, and the other is expected to include patients previously treated with Cerezyme.

"We have set a very high bar in trying to develop an oral therapy for Gaucher disease given the remarkable impact that Cerezyme has had," said David P. Meeker, M.D., Genzyme's president of Lysosomal Storage Disorder Therapeutics. "We are excited by the potential of Genz-112638. The data we collect from this study and from the Phase 3 program will provide

SOURCE Genzyme Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. WebMD Provides Preliminary First Quarter Results and Updates Financial Guidance for 2008
2. MedCath Provides Preliminary Second Quarter Fiscal 2008 Earnings and Updates Fiscal 2008 Outlook
3. TeamStaff, Inc. Reports Preliminary Second Quarter 2008 Results
4. Longs Reports Preliminary March Retail Drug Store Sales
5. Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU
6. Conseco Reports Preliminary Fourth Quarter and Year-End Results
7. NBTY to Webcast Presentation at Bank of America Consumer Conference: Announces Preliminary Sales and the Repurchase of 6.1 Million Shares
8. Longs Reports Preliminary February Retail Drug Store Sales
9. CRH Medical reports preliminary year end results
10. Sunrise Reports Preliminary Selected Financial and Operating Data for Fourth-Quarter 2007
11. KV Pharmaceutical Reports Record Revenues for Fiscal 2008 Third Quarter and Year-to-Date on a Preliminary Basis
Post Your Comments:
(Date:10/20/2014)... It’s hard to imagine what it’s like ... children around the world, it’s a reality. And while new ... are forced to walk barefoot on rocky terrain or sewage-lined ... with their friends. , Buckner International's Shoes for ... in October to encourage support for Air1 and while ...
(Date:10/20/2014)... October 20, 2014 Do you ever ... Here comes a wonderful app Metassessor for teachers, specialists ... company helped its client “Intervention Development LLC” to ... app is designed for iOS 4.3 or later and ... app is optimized for iPhone 5. It is now ...
(Date:10/19/2014)... October 20, 2014 Recently,, one ... unveiled its new range of bamboo deckings . ... these natural items; they are now available at deeply ... people, it is hard to overstate the significance of ... attention to online services. The company’s workers are striving ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
(Date:10/19/2014)..., a professional company of women’s ... for long evening dresses . All the company’s ... the current discount is up to 66 percent off. ... in the fashion field. Its dress specialists are striving ... various parts of the world. All the company’s items ...
Breaking Medicine News(10 mins):Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Promotion For Beautiful Long Evening Dresses Launched By 2
... an evening news program without hearing about an out-of-control ... how safe and comfortable is the clothing ... fires? Researchers at North Carolina State University are working ... gear worn by wildland firefighters to protect against ...
... bovine tuberculosis (TB) outbreaks increases the risk of infection in ... by researchers at the Medical Research Council Centre for Outbreak ... in the Royal Society journal Biology Letters . ... to license farmers to organise the widespread culling of badgers ...
... are at war and both the conflict and aftermath have ... published in BioMed Central,s open access journal Conflict and ... access to family planning, these services are often not available ... further deprivation and unintended pregnancy. It is often the ...
... by a U-M neurologist, better understanding of the anatomy of ... iPhone. Nerve Whiz is a free application for medical ... plexuses, and peripheral nerves. It can work on Apple personal ... be available for Android devices. The application goes beyond ...
... 12 (HealthDay News) -- Scorching heat and oppressive humidity continued ... exceeding 90 degrees -- and in some cases 100 degrees ... wave is prompting doctors to warn that high temperatures can ... "The body has ways of keeping itself cool, by ...
... a traditional Chinese herbal remedy might help treat deadly ... at the Ohio State University Comprehensive Cancer Center ... Research Institute (OSUCCC James)., The researchers discovered that ... cells, preventing their spread to other areas of the ...
Cached Medicine News:Health News:Research hopes to improve suits for fighting wildfires 2Health News:Localized reactive badger culling raises bovine tuberculosis risk, new analysis confirms 2Health News:Family planning in conflict 2Health News:An app for your brain: new educational tool developed by U-M doctor 2Health News:Soaring Temps Can Pose Serious Health Risks 2Health News:Soaring Temps Can Pose Serious Health Risks 3Health News:Indirubin -- Component Of Chinese herbal remedy might block brain tumor's spread 2
(Date:10/19/2014)... -- Henry Schein, Inc. (NASDAQ: HSIC ), the ... to office-based dental, animal health and medical practitioners, announced ... Inc., a leading full-service provider of dental consumables, implants ... into Japan , the world,s 2 ... the number of countries in which the Company operates. ...
(Date:10/18/2014)... 18, 2014  In a policy paper ... the nation,s largest lesbian, gay, bisexual and transgender ... of Truvada for Pre-Exposure Prophylaxis (PrEP). PrEP is ... prevent the spread of a disease or infection ... name anti-HIV drug combination currently approved for PrEP, ...
(Date:10/17/2014)... 17, 2014  Training market researchers to spot ... factor in today,s highly competitive global marketplace. As ... that effectively and efficiently produce high performing analysts, ... Effective training programs can help ... from internal clients by developing analysts who can ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2
... LLC today announced the appointment of Erica L. Mann as ... business based in Morristown, NJ, USA, with operations in more ... million.  Ms. Mann also becomes a member of the Bayer ... 14, 2011. Ms. Mann most recently served as ...
... NEW YORK, Feb. 22, 2011 announces ... in its catalogue: North American ... This research covers the state ... and restraints for growth, key trends, and end-user ...
Cached Medicine Technology:Erica L. Mann, Former Pfizer Executive, Appointed New President of Bayer HealthCare's Global Consumer Care Division 2Erica L. Mann, Former Pfizer Executive, Appointed New President of Bayer HealthCare's Global Consumer Care Division 3
Used for dilation of a tract to the kidney for removal of stones. Supplied sterile in peel-open packages. Intended for one-time use....
... via the pelvic nerves has proven to ... incontinence. Through the use of mild electrical ... can be strengthened to encourage urinary control ... to its patients as a tool to ...
... High Dose Rate (HDR) treatment system includes ... Sandwich. Using the Template, simply load ... the Template, suture the Sandwich to the ... the needles in place for the duration ...
... The Prostate Stepper Template Set is the ... dose seed implantation technique. The template set ... that can be sutured to the patient ... with variable ultrasound Grid Face Plates. The ...
Medicine Products: