Navigation Links
Pregnant women who exercise protect their offspring against long-term neurodegenerative diseases
Date:9/26/2011

Bethesda, MDIf you are pregnant, here's another reason to work out: you will reduce the chances of your new baby developing neurodegenerative diseases, such as Alzheimer's, later in life. A new research report published online in The FASEB Journal (http://www.fasebj.org) shows that mice bred to develop a neurodegenerative disease roughly equivalent to Alzheimer's disease showed fewer signs of the disease and greater brain plasticity later in life when their mothers exercised regularly than those whose mothers did not exercise.

"This research provides an experimental rationale for the effects of beneficial behavioral stimuli experienced by the pregnant mother affecting the disease status of an as yet-unborn child. Epigenetic alterations (alterations in gene and protein expression caused by mechanisms other than changes in the underlying DNA sequence) provide a most probable mechanism by which mothers could have transferred their own behavioral experience to their progeny," said Kathy Keyvani, M.D., a researcher involved in the work from the Institute of Pathology and Neuropathology at the University Hospital Essen in Essen, Germany. "A better understanding of the underlying pathways may provide novel treatment and/or prevention strategies for Alzheimer's disease and bring more insight into the fascinating link between brain and behavior."

To make this discovery, Keyvani and colleagues mated male mice that express a mutant form of the APP gene found in some Alzheimer's patients with healthy female wild-type mice. After weaning, healthy and "Alzheimer-diseased" offspring were kept in standard cages for five months. Mouse brains were examined for signs of disease shortly thereafter. The "Alzheimer-diseased" mice whose mothers ran on a exercise wheel during pregnancy had fewer Beta-amyloid plaques, smaller plaque size, less inflammation, less oxidative stress, and a better functioning vascular network than those whose mothers did not run. Additionally, the mice whose mothers ran on the wheel also showed an up-regulation of plasticity-related molecules, which are indicators for more and better connections between the nerve cells.

"No one is resistant to the health benefits of exercise," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and this research confirms that reasonable workouts can have a lifetime of benefits for your offspring. Whether you work out at home or go to the gym, you should do it for the sake of your health and that of your offspring."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. A mothers occupation while pregnant can cause asthma in children
2. Low-fat yogurt intake when pregnant may lead to child asthma and hay fever
3. Pregnant Women Reminded to Get Flu Vaccine
4. Stroke risk in pregnant women 2.4 times higher
5. BMC conducts high rates of thyroid testing in pregnant women, study finds
6. Flu Shots for Pregnant Women Also Protect Newborns, Study Finds
7. Study Finds Inconsistent Care for Pregnant Women With Depression
8. Pregnant Women May Go to Great Lengths to Induce Labor
9. Anti-HIV gel being evaluated in pregnant and breastfeeding women
10. Depressed, pregnant women receive inconsistent treatment, have longer hospital stays
11. Undernourishment in pregnant, lactating females found key to next generations disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: