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Pregnancy is safe for women with estrogen receptor positive breast cancer
Date:3/20/2012

ot become pregnant. Importantly, the study included only women whose oestrogen receptor status (positive or negative) and disease outcome were known. In addition, women in the control group had not relapsed at the time the matched case became pregnant; this enabled the researchers to adjust as far as possible for the "healthy mother effect" a phenomenon whereby the results could be influenced by the fact the women who became pregnant might be healthier than breast cancer patients in the control group.

The researchers followed the women up for an average of 4.7 years after pregnancy. During this period, 30% of the total of 1,207 women had a recurrence of their disease.

Dr Azim said: "Out of all the women, 57% had ER+ disease, but the study showed there was no difference in the length of time women with either ER+ or ER negative [ER-] disease survived without their disease recurring compared with those who did not become pregnant. In addition, we found that patients who became pregnant within two years of breast cancer diagnosis appeared to have a better disease-free survival compared to those who did not become pregnant. However, a clear trend over time was not demonstrated; hence this finding should be interpreted with caution as it could be confounded by potential selection bias, and hence pregnancy within two years of diagnosis should be regarded as safe, and not as protective.

"A secondary objective in this study was to determine the impact of pregnancy on overall survival. We found that breast cancer patients who became pregnant also had a lower risk of death compared to their matched controls, irrespective of ER status."

Neither breastfeeding nor abortion (either in the form of a spontaneous miscarriage or an induced abortion) had an effect on the women's outcome. "Frequently when women with history of breast cancer become pregnant, some physicians advise them to have an abortion for fear that completing the pregnancy coul
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Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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