Navigation Links
Pregnancy exposures determine risk of breast cancer in multiple generations of offspring
Date:9/11/2012

ats given a high fat diet during pregnancy compared to the offspring of control rats which ate a normal diet during pregnancy. The increased risk did not extend to the great-granddaughters of high-fat fed rats.

"We also found that if the mother was fed a high fat diet before conception and throughout pregnancy, the risk of increased breast cancer was transmitted to granddaughters through either males or females exposed to the high fat diet in utero," says the study's lead investigator, Sonia de Assis, Ph.D., a postdoctoral researcher in Hilakivi-Clarke's laboratory.

In the other group, rats were fed a diet supplemented with estrogen during the last week of pregnancy, and the control rats were fed a normal diet. The researchers found a 50 percent higher incidence of breast tumors in the exposed rats' daughters, granddaughters, and great-granddaughters, compared to the control group. In this case, increased breast cancer risk was transmitted to granddaughters through the in utero estrogen exposed females only.

Both the high-fat and excess estrogen diets produced breast tissue in the affected generations of female offspring that had more than the normal number of terminal end buds, structures that are the building blocks of mammary epithelial tree and primary targets for carcinogens.

The researchers also documented epigenetic changes in the mammary glands of all three generations of pregnant rats exposed to estrogen.

"Germ cells cells involved in reproduction first develop during the fetal period and in utero exposures, such as the ones in our study, could disrupt their normal epigenetic marks and affect how genes are turned on or turned off," de Assis says. "Those alterations then can be passed on and affect the risk of disease, in this case breast cancer, in subsequent generations."

Hilakivi-Clarke points out that two-thirds of human familial breast cancers have no known genetic mutations. She says the effect seen from a high-fat die
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Breast cancer risks acquired in pregnancy may pass to next 3 generations
2. Rise in Pregnancy-Associated Cancers Not Fully Explained by Older Age
3. Teen Obesity Linked to Moms Smoking in Pregnancy: Study
4. No Truth to Candidates Claim That Rape Hinders Pregnancy, Experts Say
5. Smoking During Pregnancy May Cause Asthma, Wheezing in Kids
6. Smoking during pregnancy increases the risk of wheeze and asthma in preschool children
7. High-Potency Pot in Pregnancy May Cause Brain Damage
8. Chemo During Pregnancy Doesnt Seem to Harm Newborn
9. Drinking in Pregnancy Shows Up in Childs Growth: Study
10. Pregnancy May Raise Risk of Cerebral Bleeding in Some Women
11. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... MillionaireCasket.com is a professional supplier of funeral products. According to ... well in the global market. Recently, the company has announced ... a special offer for all the newly released items. ... caskets are made with superb materials. As is commonly noted, ... respect to the departed saint. MillionaireCasket.com is always here to ...
(Date:7/13/2014)... 13, 2014 Intraocular Lens (IOL) Market: ... 2013 - 2019 , Intraocular lens (IOL) is inserted ... or cataracts. The lenses are inserted inside the eye, ... intraocular lens replaces the focusing power of natural lens. ... lens to deliver the light focusing function which was ...
(Date:7/13/2014)... Victorian Hotel has recently announced that ... of bikes for its "Cycle the City" program, which ... tour the area using a rental bicycle, available for ... to call Vancouver home, as it is a city ... picturesque journeys through the countryside. Vancouver hotel rooms often ...
(Date:7/13/2014)... additives are chemicals, which are added to various fuels ... on, in order to enhance their performance. Fuel additives ... by fuels and improving the combustion properties of fuels. ... scale in the long run, but, in the short ... products. , The various fuel additive types include deposit ...
(Date:7/13/2014)... The Pearland, Texas location of The Little Gym, a ... to 12 years of age that offers everything from gymnastics, ... Summer Camps, is now under new ownership. , Kevin Berry ... spending over six years at The Little Gym of Bellaire ... Berry has over ten years of experience working with children, ...
Breaking Medicine News(10 mins):Health News:Brand New Cherry Caskets Unveiled By China Casket Supplier MillionaireCasket.com 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2
... ... leads through your website. , ... (PRWEB) November 24, 2009 -- 2009 has been another tough year for the U.S. economy. ... afloat and reduce costs. Typically the first items on the chopping block are things like ...
... , 2009 Q3 Financials, S-1 Registration Statement being Prepared ... WESTON, Fla., Nov. 24 American Scientific Resources Inc. (Pink Sheets: ... update. , Since filing 2007 and 2008 audited financials on Pinksheets ... all part of a long term business plan for the Company. ...
... study finds , TUESDAY, Nov. 24 (HealthDay News) -- ... are at increased risk for asthma, researchers say. , ... an immune response in humans -- is found in ... found persistent wheezing (an early warning sign of asthma ...
... Jamba, Inc. (Nasdaq: JMBA ) announced today the ... Juice(TM) Smoothie and Ice Pop Maker, a Jamba Juice-branded toy ... Created together with Think Wow Toys, the EZ-2 MAKE! ... at a leading toy retailer, starting mid-November. The toy ...
... ... and keep an ongoing dialogue with patients. Through Facebook, Twitter, and other social media outlets, ... answer any questions that patients may have. , ... Atlanta, GA (Vocus) November 24, 2009 -- A plastic surgeon in ...
... ... Monthly Revenue for Central Stations and Security Dealers. , ... Dallas, Texas (PRWEB) November 24, 2009 -- NCL ... Revenue for Central Stations and Security Dealers., , ,"Integrated security systems has been and ...
Cached Medicine News:Health News:We Do Web Content Offers Free Lead Generation Report 2Health News:We Do Web Content Offers Free Lead Generation Report 3Health News:American Scientific Resources Inc. Issues Corporate Update 2Health News:American Scientific Resources Inc. Issues Corporate Update 3Health News:Traffic, Dust Linked to Asthma in Kids 2Health News:Jamba Juice and Think Wow Toys Bring the Smoothie Experience Home With Debut of Jamba Branded Toy Blender 2Health News:Jamba Juice and Think Wow Toys Bring the Smoothie Experience Home With Debut of Jamba Branded Toy Blender 3Health News:Atlanta Plastic Surgeon Using Social Media To Connect with Patients 2Health News:Atlanta Plastic Surgeon Using Social Media To Connect with Patients 3Health News:NCL Security Launches EyeCentral Video Platform for the Security Industry to Generate Recurring Monthly Revenue for Central Stations and Security Dealers 2
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... MILTON, N.Y. , Jan. 15, 2014 Sono-Tek Corporation ... three months ended November 30, 2013, compared to sales of ... or 20%. Once again, this quarter has also shown growth ... in the first quarter of this fiscal year. Markets that ...
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across the ... select Meijer pharmacies in Michigan will ... eligible patients, enabling Meijer pharmacists to administer tests and, in ... by a physician participating in the study. The ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: