Navigation Links
Pregnancy Weight Gain, Especially in 1st Trimester, May Increase a Woman's Risk of Gestational Diabetes

OAKLAND, Calif., Feb. 22 /PRNewswire/ -- Women who gain excessive weight during pregnancy, especially in the first trimester, may increase their risk of developing diabetes later in their pregnancy, according to a study by the Kaiser Permanente Division of Research that appears online in the current issue of Obstetrics and Gynecology.

The three-year study of 1,145 pregnant women from an ethnically diverse population found that women who gained more weight than is recommended by the Institute of Medicine had a 50 percent increased risk of developing gestational diabetes mellitus, also known as GDM. The association between pregnancy weight gain and gestational diabetes risk was more pronounced among overweight and non-white women. The study included 345 pregnant women with gestational diabetes and 800 pregnant women without gestational diabetes.

Gestational diabetes is defined as glucose intolerance that typically occurs during the second or third trimester of pregnancy. It causes complications in as much as seven percent of pregnancies in the United States. It can lead to early delivery, C-sections and type 2 diabetes, and can increase the child's risk of developing diabetes and obesity later in life.

This study is among the first to support a direct link between pregnancy weight gain and gestational diabetes risk. Previous research has shown that weight gain before pregnancy and being overweight or obese at the start of pregnancy are risk factors for gestational diabetes. This study was funded by the American Diabetes Association and the National Institute of Diabetes and Digestive and Kidney Diseases.

The study followed women members of Kaiser Permanente Northern California region and examined their overall rate of pregnancy weight gain up to the time of screening for gestational diabetes (typically between 24-28 gestational weeks), as well as the trimester-specific rates of weight gain compared to the Institute of Medicine's 2009 guidelines for recommended pregnancy weight gain. Based on a woman's pre-pregnancy body mass index, the IOM developed the 2009 guidelines for obstetricians to counsel pregnant women on suggested weight gain during pregnancy.

After adjusting for age at delivery, race/ethnicity, previous births, and pre-pregnancy body mass index, the risk of gestational diabetes increased with increasing rates of pregnancy weight gain. Women who exceeded the IOM guidelines for weight gain had a 50 percent increase in the risk of gestational diabetes compared to women who gained within or below the IOM recommendations.

"Health care providers should talk to their patients early in their pregnancy about the appropriate gestational weight gain, especially during the first trimester, and help women monitor their weight gain. Our research shows that weight gain in early pregnancy is a modifiable risk factor for gestational diabetes," said the study's lead author Monique Hedderson, PhD, a scientist at the Kaiser Permanente Division of Research. "Randomized studies are needed to determine the feasibility of this early intervention and the best methods to help women meet the IOM recommendations."  

Though the exact mechanism for how excessive weight gain may contribute to gestational diabetes is not known, researchers hypothesize that rapid weight gain early in pregnancy may result in an early increase in insulin resistance that leads to the "exhaustion" of the beta-cells in the pancreas that make and release insulin, which controls the level of glucose in the blood. This could reduce beta-cells' capacity to secrete adequate levels of insulin to compensate for the insulin resistance induced by the progression of pregnancy and therefore lead to the development of gestational diabetes, researchers said.

A strength of the study is its representative and ethnically diverse population. However, some limitations should be considered. Pre-pregnancy weights were self-reported for most women. However, researchers have no reason to believe that the women who developed gestational diabetes would have misreported their pre-pregnancy weight more than control women and results were similar when looking at the sub-group of women who had a measured pre-pregnancy weight.

This study is part of ongoing research at Kaiser Permanente to understand, prevent and treat gestational diabetes. A recent published Kaiser Permanente study of 16,000 women in Hawaii found that more than 10 percent of women of Chinese and Korean heritage may be at risk for developing gestational diabetes. Another published Kaiser Permanente study of 10,000 mother-child pairs showed that treating gestational diabetes during pregnancy can break the link between gestational diabetes and childhood obesity. That study showed, for the first time, that by treating women with gestational diabetes, the child's risk of becoming obese years later is significantly reduced.

The study follows other research at Kaiser Permanente regarding healthy weight gain during pregnancy. A recent published Kaiser Permanente study found that obese women who gain more than the recommended amount during pregnancy are much more likely to retain a portion of that weight one year after they give birth. Another published Kaiser Permanente study of 40,000 mother and baby pairs found that women who gained more than 40 pounds during their pregnancies were nearly twice as likely to have a heavy baby.

Assiamira Ferrara, MD, PhD, a research scientist with the Kaiser Permanente Division of Research in Oakland, Calif., is the senior investigator on this study. Erica P. Gunderson, PhD, also with the Kaiser Permanente Division of Research, is an investigator on this study.

The Institute of Medicine guidelines on pregnancy weight gain can be found here:

About the Kaiser Permanente Division of Research (

The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and the society at large. It seeks to understand the determinants of illness and well-being and to improve the quality and cost-effectiveness of health care. Currently, DOR's 500-plus staff is working on more than 250 epidemiological and health services research projects.

About Kaiser Permanente

Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services to improve the health of our members and the communities we serve. We currently serve 8.6 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to:

SOURCE Kaiser Permanente

Back to top



SOURCE Kaiser Permanente
Copyright©2010 PR Newswire.
All rights reserved

Related medicine news :

1. AT&T Foundations $50,000 Donation to National Health Foundation Supports Teen Pregnancy Prevention Program
2. Excessive Weight Gain During Pregnancy Raises Gestational Diabetes Risk
3. Acupuncture May Ease Depression During Pregnancy
4. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
5. Wiser Pregnancy Reveals What Doctors Did In Situations Like Yours
6. Moms Lifestyle in Early Pregnancy Affects Babys Size
7. Depression in Pregnancy May Lead to Antisocial Teens
8. Acupuncture found effective against depression during pregnancy
9. Care Net Calls Tebow Ad Opponents Slam of Pregnancy Centers Nonsensical
10. Stress, Anxiety Can Up Risk of Depression in Pregnancy
11. Enjoy Pregnancy without Foot Pain
Post Your Comments:
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in ... involving adult stem cell therapies to patients with chronic degenerative medical conditions. Now, ... a Registered Trademark (RTM). , Organizations are required to hold a registered trademark ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software helps practice ... an agreement between the practice owner and the patient that automatically manages all ... projections. Click here to learn more. , According to ...
(Date:11/24/2015)... , ... November 24, 2015 , ... New patients who ... a referral for dental implants at her Mississauga, ON practice. Dr. Williams ... in the placement of dental implants. , Missing teeth can lead to a ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and ... signed an agreement for DILON to distribute GE,s Discovery ... the globe. The signing of this distribution agreement will provide ... Molecular Breast Imaging system and is considered an initial ... better healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... 24, 2015 . ... adds Latest Guidebook for Chinese Medical Device ... published in November 2015 to the medical devices ... library at . ... growing global economies with a fifth population in ...
(Date:11/24/2015)... -- Figure 1, a free mobile-first network that enables healthcare ... a new completely redesigned web version that includes uploading. ... work primarily on a desktop, to upload images directly ... user base, Figure 1 is hosting an event during ... (RSNA) Annual Meeting. Joshua Landy ...
Breaking Medicine Technology: