Navigation Links
Preeclampsia May Stem From Malformed Proteins
Date:1/30/2009

Yale researchers say discovery could lead to earlier diagnosis, treatment

FRIDAY, Jan. 30 (HealthDay News) -- Misfolded proteins may be the cause of preeclampsia, say Yale University researchers. And, they say, the proteins are easy to detect in urine, which could offer a new method of early diagnosis of the common and serious hypertension complication of pregnancy.

In a study of 111 pregnant women, the researchers identified key abnormal proteins in the women's urine weeks before they showed clinical signs of preeclampsia. The urine test designed by the researchers was based on a dye that sticks to misfolded, or incorrectly formed, proteins.

"These results support the hypothesis that preeclampsia is a pregnancy-specific protein misfolding disease," Dr. Irina Buhimschi, an associate professor in the department of obstetrics, gynecology and reproductive sciences and the study's lead author, said in a Yale news release.

"Our findings are compelling for several reasons," she said. "This novel identification of preeclampsia as a disorder of protein misfolding opens a door for researchers that may lead to testing of new drugs or developing new therapies. Our future work will seek to determine whether the different shapes employed by the misfolded proteins in preeclampsia are linked to specific clinical symptoms and the different ways this intriguing disease manifests."

The study was expected to be presented Jan. 30 at the Society for Maternal-Fetal Medicine's annual meeting in San Diego.

Preeclampsia is one of the most common causes of death in pregnant women in the United States and kills about 76,000 women worldwide each year, according to background information in the news release. The condition is also a leading cause of preterm delivery. Establishing a correct diagnosis of preeclampsia can be difficult, especially in women with preexisting hypertension, lupus or kidney disease. Currently, delivery is the only reliable treatment for preeclampsia.

More information

The U.S. National Institute of Child Health and Human Development has more about preeclampsia and eclampsia.



-- Robert Preidt



SOURCE: Yale University, news release, Jan. 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Preeclampsia in Pregnancy Boosts Future Health Risks
2. Preeclampsia Might Protect Against Testicular Cancer
3. Research May Help Predict Preeclampsia
4. Preeclampsia Linked to Cardiovascular Problems After Pregnancy
5. New finding may help explain development of preeclampsia
6. Extra Doses of Vitamins C, E Dont Guard Against Preeclampsia
7. Preeclampsia Linked to Heart Disease Risk
8. Spinal fluid proteins signal Lou Gehrigs disease
9. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
10. Two cardiovascular proteins pose a double whammy in Alzheimers
11. Stopping ovarian cancer by blocking proteins coded by notorious gene
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preeclampsia May Stem From Malformed Proteins
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: