Navigation Links
Preeclampsia May Stem From Malformed Proteins
Date:1/30/2009

Yale researchers say discovery could lead to earlier diagnosis, treatment

FRIDAY, Jan. 30 (HealthDay News) -- Misfolded proteins may be the cause of preeclampsia, say Yale University researchers. And, they say, the proteins are easy to detect in urine, which could offer a new method of early diagnosis of the common and serious hypertension complication of pregnancy.

In a study of 111 pregnant women, the researchers identified key abnormal proteins in the women's urine weeks before they showed clinical signs of preeclampsia. The urine test designed by the researchers was based on a dye that sticks to misfolded, or incorrectly formed, proteins.

"These results support the hypothesis that preeclampsia is a pregnancy-specific protein misfolding disease," Dr. Irina Buhimschi, an associate professor in the department of obstetrics, gynecology and reproductive sciences and the study's lead author, said in a Yale news release.

"Our findings are compelling for several reasons," she said. "This novel identification of preeclampsia as a disorder of protein misfolding opens a door for researchers that may lead to testing of new drugs or developing new therapies. Our future work will seek to determine whether the different shapes employed by the misfolded proteins in preeclampsia are linked to specific clinical symptoms and the different ways this intriguing disease manifests."

The study was expected to be presented Jan. 30 at the Society for Maternal-Fetal Medicine's annual meeting in San Diego.

Preeclampsia is one of the most common causes of death in pregnant women in the United States and kills about 76,000 women worldwide each year, according to background information in the news release. The condition is also a leading cause of preterm delivery. Establishing a correct diagnosis of preeclampsia can be difficult, especially in women with preexisting hypertension, lupus or kidney disease. Currently, delivery is the only reliable treatment for preeclampsia.

More information

The U.S. National Institute of Child Health and Human Development has more about preeclampsia and eclampsia.



-- Robert Preidt



SOURCE: Yale University, news release, Jan. 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Preeclampsia in Pregnancy Boosts Future Health Risks
2. Preeclampsia Might Protect Against Testicular Cancer
3. Research May Help Predict Preeclampsia
4. Preeclampsia Linked to Cardiovascular Problems After Pregnancy
5. New finding may help explain development of preeclampsia
6. Extra Doses of Vitamins C, E Dont Guard Against Preeclampsia
7. Preeclampsia Linked to Heart Disease Risk
8. Spinal fluid proteins signal Lou Gehrigs disease
9. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
10. Two cardiovascular proteins pose a double whammy in Alzheimers
11. Stopping ovarian cancer by blocking proteins coded by notorious gene
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preeclampsia May Stem From Malformed Proteins
(Date:8/22/2017)... VEGAS, NEV. (PRWEB) , ... August 22, 2017 ... ... American Academy of Anti-Aging Medicine recently spoke at a popular international aesthetics conference ... therapy has had on restoring his patients’ health and his growing practice. , ...
(Date:8/22/2017)... ... August 22, 2017 , ... Five Star Glass is new to the Texas market, ... replacement of auto glass for most makes and models, in Grand Prairie, TX, located in ... , They have been a family owned business for the past 40 years with 32 ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a unique ... Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, traveler, ... to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least understood ...
(Date:8/21/2017)... ... 22, 2017 , ... PracticeMatch, a company that provides online resources , ... and advanced practitioners like nurse practitioners and physician assistants , will ... of this year. The online career fairs will allow job seekers to connect with ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... ... today announced that it has become the Official Technology Partner of North Country ... AES (Advanced Event Systems) volleyball software, along with providing sport management software ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... June 30, 2017, and updated its financial outlook for ... For the fiscal third quarter, Hill-Rom reported earnings of ... share in the prior-year period. These results reflect after-tax ... share primarily related to the non-cash write-down of assets ...
(Date:7/27/2017)...  West Pharmaceutical Services, Inc. (NYSE: WST ... 2017 and updated financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, ... Net sales at constant currency (organic) grew by 3.9%. ... compared to $0.60 in the prior-year quarter. Second-quarter 2017 ...
(Date:7/26/2017)... , July 26, 2017 Sancilio Pharmaceuticals Company, ... our clinical trial evaluating Altemia TM , an oral ... and Sickle Cell Disease (SCD). The SCOT Trial, is ... efficacy and safety of Altemia TM in pediatric ... under US IND 125274. ...
Breaking Medicine Technology: