Navigation Links
Preeclampsia Linked to Cardiovascular Problems After Pregnancy

Insulin resistance increases and arteries malfunction years later, researchers say

TUESDAY, June 24 (HealthDay News) -- Preeclampsia may change the way arteries respond to insulin, thereby increasing the risk of cardiovascular problems years after the dangerous pregnancy complication occurs, Scandinavian researchers report.

In this small study, researchers found an association between insulin sensitivity in women and a history of preeclampsia, which is high blood pressure during pregnancy.

"Although insulin sensitivity in non-obese women with previous preeclampsia is similar to that in control women, there was a significant correlation between waist-to-hip ratio and serum triglycerides and insulin sensitivity only in women with history of preeclampsia," said lead researcher Dr. Risto Kaaja, a researcher at Helsinki University Hospital in Finland.

"Secondly, insulin sensitivity correlated to vasodilatation again only in the preeclamptic group," Kaaja said. "Early-onset preeclampsia correlated to impaired insulin sensitivity later in life."

The study was published in the June 23 early online edition of Hypertension.

In the study, Kaaja's team looked at 28 non-obese women who had severe preeclampsia during pregnancy and compared them with 20 women who had normal pregnancies. After five to six years, researchers found an association between insulin sensitivity and dysfunction in the arteries among women with a history of preeclampsia, but not among women who had had normal pregnancies.

"We have been the first to suggest that preeclampsia could be the first manifestation of the metabolic syndrome," Kaaja said. "Although preeclampsia is mainly cured after delivery, features of the metabolic syndrome have been shown to prevail for months to several years after a preeclamptic pregnancy," he said.

"We showed that this impairment is related to insulin sensitivity and also with waist-to-hip ratio," Kaaja said, "meaning that women with history of preeclampsia could be more sensitive to harmful effects of gaining weight and increased waist-hip ratio, leading to insulin resistance and increased risk for atherosclerosis."

These women should be told about their increased risk for cardiovascular disease, Kaaja said.

Women with a normal waist-hip ratio who had preeclampsia should be careful not to gain weight later in life, Kaaja said.

In addition, blood pressure, cholesterol and blood sugar levels should be checked regularly among women with a history of preeclampsia. "With increasing waist-to-hip ratio, they will become insulin-resistant, and their vasodilatation will be impaired," Kaaja said. "Both factors, insulin resistance and impaired vasodilatation, lead to cardiovascular diseases."

Preeclampsia affects between 5 percent and 8 percent of all pregnancies. The condition is characterized by high blood pressure and protein in the urine. Common symptoms include swelling, sudden weight gain, headaches, and changes in vision. However, some women report few symptoms.

Dr. Byron Lee, an associate professor of cardiology at University of California, San Francisco, thinks this study helps explain why women with a history of preeclampsia are at risk for heart disease.

"Although we have known for awhile that women with a history of preeclampsia are at increased risk of coronary artery disease, we were not sure why," Lee said. "This study suggests that the body fat may be the link. Therefore, women who have had preeclampsia should be extra careful to keep off excess weight."

More information

For more on preeclampsia, visit the National Institutes of Health.

SOURCES: Risto Kaaja, M.D., D.M.Sc., researcher, Helsinki University Hospital, Finland; Byron Lee, M.D., associate professor, cardiology, University of California, San Francisco; June 23, 2008, Hypertension, online

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New finding may help explain development of preeclampsia
2. Extra Doses of Vitamins C, E Dont Guard Against Preeclampsia
3. Preeclampsia Linked to Heart Disease Risk
4. Severe retinal hemorrhaging is linked to severe motor vehicle crashes
5. Pennsylvania Department of Health Confirms Fifth Salmonella Case Linked to National Outbreak
6. Pennsylvania Department of Health Investigates Salmonella Cases Linked to National Outbreak
7. Cancer Drug Gleevec Linked to Muscle Damage
8. Gene variants linked to metabolic syndrome and HDL cholesterol levels
9. Hot flashes underreported and linked to forgetfulness
10. Poor sleep linked to suicidal behavior among children and adolescents with depressive episodes
11. Frequent self-cutting linked to risky sexual behavior in teens
Post Your Comments:
Related Image:
Preeclampsia Linked to Cardiovascular Problems After Pregnancy
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
Breaking Medicine Technology: