Navigation Links
Predisposing factors for conversion of mild cognitive impairment to AD identified
Date:3/1/2010

Amsterdam, March 1, 2010 Mild cognitive impairment (MCI) is often considered an early symptom of Alzheimer's disease (AD). An analysis of genetic risk factors predisposing to MCI is critical for accessing individual predisposition and reliably evaluating the effectiveness of early treatment. In a groundbreaking study published in the February 2010 issue of the Journal of Alzheimer's Disease investigators successfully used artificial neural networks (ANNs) to help understand the causal relation between multiple factors and the occurrence of neurodegenerative disorders.

ANNs are computer algorithms inspired by the highly interactive processing of the human brain. Like the brain, they can recognize patterns, manage data and learn. This novel form of data analysis can accurately detect complex relationships between independent and dependent variables. When exposed to a complex data set, they recognize the underlying mechanisms of time series and outcomes, thus identifying complex interactions among input data, and recognising hidden relations that are not apparent using traditional statistical methods.

Using ANNs a team of researchers lead by Massimo Tabaton, University of Genova, Italy, analyzed 22 variables, which are recognized risk factors of AD in patients with MCI. Analysis indicated that hyperglycemia, female gender and the apoE4 genotype, in this order, were the biological variables with the highest relevance for predicting the conversion of MCI into AD within 2 years. This was followed by the scores on attentional and short memory tests.

Professor Tabaton and his colleagues commented, "This finding may have implications in clinical practice, as genetic variations can be easily examined and combined with other biomarkers, personal history and environmental exposure to establish a tailored risk profile. In fact, adjustment for the baseline risk, which should be more accurately assessed by taking into account genetic variations, would be required to estimate the utility of therapeutic and preventive intervention."

"This work highlights the biological and genetic basis for the conversion of benign forgetfulness to AD and directs our efforts to new therapeutic avenues," agree George Perry and Mark A. Smith, Editors-in-Chief of the Journal of Alzheimer's Disease.


'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Study, meta-analysis examine factors associated with death from heatstroke
3. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
4. Severe heart defect likely caused by genetic factors
5. Aggressively Treating Cardiac Risk Factors May Reverse Ischemia
6. Largest Study Ever to Investigate Risk Factors of Autism and Other Developmental Disabilities Will Begin Enrolling Families in Bay Area and Across U.S.
7. Age, burden, divorce and heavy tea consumption are significant risk factors for erosive esophagitis
8. Cell Addiction to Growth Factors May Help Spur Cancers
9. Study examines factors associated with survival in advanced laryngeal cancer
10. Cardiovascular disease death rates decline, but risk factors still exact heavy toll
11. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... , ... March 24, 2017 , ... ... planning, and related services to families and business owners across eastern Michigan, is ... feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, ... Claims Litigation seminar in Chicago, Illinois. She will present on: , Filing ... litigated under ERISA involve claims for long-term disability benefits. This session will ...
(Date:3/24/2017)... ... 24, 2017 , ... Judy Buchanan, co-owner of Serenity Natural ... Judy says, “I am passionate about sharing Reiki as a holistic, complementary therapy ... challenging time.” , A Certified Medical Reiki™ Master trained by Raven Keys Medical ...
(Date:3/24/2017)... ... 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks at ... his life to the fullest, as God intended. “The Adventures of Joey, The Dog ... and grandmother pursuing her passion for writing, especially about truth and human behavior. , ...
(Date:3/23/2017)... Braunfels, TX (PRWEB) , ... March 23, 2017 , ... ... new clinic, located at 960 Gruene Road in Building 2. The clinic is the ... Dr. Andrew Bennett, PT, says opening the company’s second New Braunfels location brings things ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... PUNE, India , March 24, 2017 Abdominal ... to reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% from 2016 ... revenue, and is projected to dominate the market during the study period. ... ... Logo ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... report to their offering. ... The global wound care market was worth $24,482.9 million in 2015 ... 2016-2022 Among the various wound care products type, the advanced ... in 2015. Among the various applications, surgical wound segment held the largest ...
(Date:3/24/2017)... March 24, 2017 ShangPharma, a ... and cost-effective drug development and discovery services, ... biotechnology industry, announced today the intent for ... will be consolidating the Contract Research Organizations ... Shanghai ChemPartner. These entities include ChemPartner Shanghai, ...
Breaking Medicine Technology: