Navigation Links
Predisposing factors for conversion of mild cognitive impairment to AD identified
Date:3/1/2010

Amsterdam, March 1, 2010 Mild cognitive impairment (MCI) is often considered an early symptom of Alzheimer's disease (AD). An analysis of genetic risk factors predisposing to MCI is critical for accessing individual predisposition and reliably evaluating the effectiveness of early treatment. In a groundbreaking study published in the February 2010 issue of the Journal of Alzheimer's Disease investigators successfully used artificial neural networks (ANNs) to help understand the causal relation between multiple factors and the occurrence of neurodegenerative disorders.

ANNs are computer algorithms inspired by the highly interactive processing of the human brain. Like the brain, they can recognize patterns, manage data and learn. This novel form of data analysis can accurately detect complex relationships between independent and dependent variables. When exposed to a complex data set, they recognize the underlying mechanisms of time series and outcomes, thus identifying complex interactions among input data, and recognising hidden relations that are not apparent using traditional statistical methods.

Using ANNs a team of researchers lead by Massimo Tabaton, University of Genova, Italy, analyzed 22 variables, which are recognized risk factors of AD in patients with MCI. Analysis indicated that hyperglycemia, female gender and the apoE4 genotype, in this order, were the biological variables with the highest relevance for predicting the conversion of MCI into AD within 2 years. This was followed by the scores on attentional and short memory tests.

Professor Tabaton and his colleagues commented, "This finding may have implications in clinical practice, as genetic variations can be easily examined and combined with other biomarkers, personal history and environmental exposure to establish a tailored risk profile. In fact, adjustment for the baseline risk, which should be more accurately assessed by taking into account genetic variations, would be required to estimate the utility of therapeutic and preventive intervention."

"This work highlights the biological and genetic basis for the conversion of benign forgetfulness to AD and directs our efforts to new therapeutic avenues," agree George Perry and Mark A. Smith, Editors-in-Chief of the Journal of Alzheimer's Disease.


'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Study, meta-analysis examine factors associated with death from heatstroke
3. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
4. Severe heart defect likely caused by genetic factors
5. Aggressively Treating Cardiac Risk Factors May Reverse Ischemia
6. Largest Study Ever to Investigate Risk Factors of Autism and Other Developmental Disabilities Will Begin Enrolling Families in Bay Area and Across U.S.
7. Age, burden, divorce and heavy tea consumption are significant risk factors for erosive esophagitis
8. Cell Addiction to Growth Factors May Help Spur Cancers
9. Study examines factors associated with survival in advanced laryngeal cancer
10. Cardiovascular disease death rates decline, but risk factors still exact heavy toll
11. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... Newark, NJ (PRWEB) , ... May 25, 2016 ... ... the Kids’ Oral Health Program (KOHP), a $500,000 two-year pilot initiative to improve ... includes funding to support professional development for health care providers and promote best ...
(Date:5/25/2016)... ... May 25, 2016 , ... New studies published today by ... across 15 states. The outcomes examined in these studies include recovery of physical ... satisfaction with medical care. , “The goal of the studies is to provide ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Cheryl Bowker ... has to bestow: the Dick McKenna Good Hands Legacy Award. McKenna ran one of ... others which continues to inspire all those who knew him. The award named for ...
(Date:5/25/2016)... ... May 25, 2016 , ... Casa Velas, an adults-only boutique hotel in ... to complement its new wellness suites . The two 1,350 sq. ft. suites ... of special services and insuite amenities, from a custom soap selection and in-suite exercise ...
(Date:5/25/2016)... ... 2016 , ... Laser Skin & Wellness Center is excited to ... of female aging. The Juliet™ procedure helps to reverse the effects ... laxity, itchiness and pain have reported real relief from these and other problems by ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... India , May 25, 2016 ... Review, H1 2016"market research report that provides an ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/24/2016)... , May 24, 2016  Diana Russell suffers ... her organs from the inside out.  This disease has ... dependent on her children and grandchildren to leave her ... wheelchair, Diana,s family cannot haul the wheelchair.  So if ... the car, and Diana is left to wait for ...
(Date:5/24/2016)... 2016 The innovator of ... , s first dual therapy stent, introduces catheters ... OrbusNeich, a global company specializing in the provision ... include products to treat peripheral artery disease. The JADE™ ... devices for lower limb and arteriovenous (AV) fistula intervention. ...
Breaking Medicine Technology: