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Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
Date:7/13/2010

NEW YORK, July 13, 2010 The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinoma in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. While the mortality rates for DCIS remain low, the risk of local recurrence in the breast is high. Standard treatments following surgery include radiation therapy and hormone treatment. While both treatments have been proven to lower the risk of recurrence in the breast, neither has been shown to improve survival, and both carry potentially serious risks. In an attempt to help physicians and patients weigh the risks and benefits of the available options, researchers from Memorial Sloan-Kettering Cancer Center (MSKCC) are reporting in the Journal of Clinical Oncology on the development of a new prediction tool that calculates a patient's individualized risk for recurrence five and ten years after surgery.

"For the first time, using readily available information, a patient and her oncologist can estimate her individualized risk, and then use this tool to help in the decision-making process regarding treatment options," said Kimberly Van Zee, MD, an attending surgeon in the Breast Cancer Surgical Service at Memorial Sloan-Kettering Cancer Center and the study's lead author. "To date, there has been no other way to integrate all of the known risk factors for recurrence and come up with an individualized absolute risk estimate. This nomogram will be a valuable tool in weighing the pros and cons of various treatments."

Today, approximately one in five new breast cancer cases will be diagnosed as DCIS, making non-invasive breast cancer the fourth most commonly diagnosed malignancy in women. In 2009, more than 67,000 new cases of DCIS were diagnosed in the United States. Experts cite increased use of screening methods such as mammography as the reason for the rise in case numbers.

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Contact: Courtney DeNicola
denicolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

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