Navigation Links
Prediction of seasonal flu strains improves chances of universal vaccine

Researchers have determined a way to predict and protect against new strains of the flu virus, in the hope of improving immunity against the disease.

Influenza is a rapidly spreading acute respiratory disease. Worldwide, annual seasonal epidemics of the flu result in 3-5 million cases of severe illness, and up to 500 000 deaths. A newly emerged virus can spread across 74 countries in 2 months.

The study led by the University of Melbourne with Monash University and international colleagues has found how to predict and potentially stop the mutating cells of the influenza virus, which escape our bodies' white blood cells (T cell) immunity.

Senior author, Associate Professor Katherine Kedzierska from the Department of Microbiology and Immunology at the University of Melbourne said the finding may lead to a new universal influenza vaccine to better protect against both seasonal and pandemic outbreaks.

This research, published in PNAS today, will also help researchers understand T cell immunity against other viral infections such as HIV, Hepatitis C and tumours.

"The introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus due to minimal antibody immunity," Assoc Prof Kedzierska said.

"White blood cells called T cells are highly efficient in fighting influenza virus infection. Thus, established T cell immunity towards particular viral regions can provide 'universal' immunity against distinct seasonal and pandemic influenza strains.

"However, influenza viruses can mutate their genes to escape efficient T cells. This constitutes a major problem for a design of a universal vaccine.

In the current paper, researchers have unraveled how influenza viruses evade T cell immunity by introducing specific mutations within the viral proteins.

Professor Peter Doherty, a lead author of the study from the University of Melbourne said predicting and designing vaccines to protect against such mutants can promote T cell immunity.

"The studies suggested that an influenza vaccine that targets T cells and recognizes distinct virus strains could provide universal immunity against any future influenza strain," he said.

Contact: Rebecca Scott
University of Melbourne

Related medicine news :

1. Breast cancer risk prediction model for African American women underestimates risk
2. Astro Clairvoyant Norah Guide for Premium Astrology Publishes New Blog Series on 2013 Predictions
3. Travel Services MyTSOnline Celebrates the Holidays by Extending Lifetime Memberships and Poking Fun at the Mayan End of World Prediction
4. Prepare for 2013 - Clair-Astrologist Norah Jones Goes Social; Read Her 2013 Zodiac Predictions
5. Certified Astro-Clairvoyant Norah Guide with Premium Astrology Makes New Year Predictions for 2013
6. Weather prediction task: Learning achievement with and without stress
7. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
8. A Delicious, And Healthy New Seasonal Hot Chocolate Beverage, Xocai's Sipping Xocolate, Has Been Released By Marketing Xocolate International Corporation (MXI Corp)
9. Study examines role of seasonal prescribing changes in antibiotic resistance
10. NYC Doc Announces 3 Surprising Ways to Beat Seasonal Allergies
11. Does Your Child Have Seasonal Allergies or a Cold?
Post Your Comments:
(Date:11/25/2015)... ... , ... Smiles by Stevens is pleased to announce the addition ... many patients are aware of the benefits of Botox® in the treatment of moderate ... with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) ...
(Date:11/25/2015)... ... 2015 , ... Brillianteen, McGaw YMCA’s student-produced musical show, will ... Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for this final production ... been a treasured tradition for numerous families in the Evanston community. Over the ...
(Date:11/25/2015)... ... 25, 2015 , ... Today, Mothers Against Drunk Driving (MADD) learned ... 10,000 for the first time since 2011. In 2014, there were 9,967 fatalities involving ... by the National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When ... that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In ... She developed the patent-pending RECOVERY BRA for added comfort and support. The bra ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the ... gain, cold hands, and dry skin. But many people who find their cholesterol levels ... regimen instead of their thyroid, especially if they don’t have any of the other ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... the addition of the  "Global Drug ...  report to their offering.  --> ... addition of the  "Global Drug Device ... to their offering.  --> ...
(Date:11/24/2015)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Ron Squarer , will present at the Piper ... public is welcome to participate in the conference ... Jaffray Annual Healthcare ConferencePresenter:  , Ron Squarer, Chief ... Eastern Time Webcast: , ...
(Date:11/24/2015)... NEWPORT NEWS, Va. , Nov. 24, 2015 /PRNewswire/ ... that they have signed an agreement for DILON to ... select geographies across the globe. The signing of this distribution ... GE,s Discovery NM750b Molecular Breast Imaging system and is ... ways to provide better healthcare solutions for clinicians and ...
Breaking Medicine Technology: