Navigation Links
Predicting the value of indexing symptoms for ovarian cancer
Date:1/13/2012

The use of symptom indices to identify patients with symptoms associated with ovarian cancer who may need further screening is increasing in both the UK and the US in an attempt to promote earlier diagnosis, but they may need to be reassessed in order to help better detect cancer, according to a study published January 13 in the Journal of the National Cancer Institute.

Ovarian cancer is a disease which is perceived to rarely produce symptoms until the disease has spread to other organs of the body, allowing the disease to reach an advanced stage before it is caught. Some evidence suggests patient-reported symptoms may help detect the cancer early on, and in fact, the Goff index, which uses questionnaire data, has been reported to be effective in identifying women who are at a low to moderate risk of ovarian cancer. However, symptom assessment may greatly influence index performance.

To determine the effectiveness of the symptom indices, Anita Wey Wey Lim of the Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, at Queen Mary University of London and associates looked at data from 194 women who had recently been diagnosed with ovarian cancer and 268 control subjects who underwent ovarian cancer screenings. The symptom data was assessed through questionnaires, telephone interviews, and general practitioner notes. The sensitivity of the symptoms reported within a few months of the diagnosis was also determined by comparing two 12 month periods (0-11 and 3-14 months before diagnosis).

The researchers found that the results were similar to those found in previous reports on the Goff index and that the sensitivity of the symptoms were stronger in late- vs early-stage disease. The assessment also shows that there is only a slight variation in the symptoms reported by women with early- vs late-stage disease.

The authors note that a strong point in the study comes from a comparison of multiple data sources, which had never been done before. Even so, they write that, "The small differences between the three indices indicate that there is little to gain from deriving new symptom indices." They also suggest that while a symptom index could advance the diagnosis of ovarian cancer, the benefits of such are greatly overemphasized, given that most symptoms of the disease emerge within three months before diagnosis. They write, "At best, a symptom index might advance diagnosis of ovarian cancer by 3 months or more in two-thirds of women. For a more specific index, the sensitivity would be approximately one-third."

In an accompanying editorial, Patricia Hartge, ScD, at National Cancer Institute's Division of Cancer Epidemiology and Genetics, and James L. Speyer, MD, from the NYU Langone Cancer Center, write that symptom indices such as the Goff index and two novel indices described in the study are viewed as good for detecting early-stage ovarian cancer with the assumption that an early detection and therapy can achieve a better patient outcome. While this can be true, they caution that these indices were not highly specific and that the screeners found the cancer symptoms close to the time in which the patient was diagnosed. "The study design permits no calculation of years of life that might have been saved or lost if screeners actually were usedonly a large and expensive randomized trial would do thatbut clinical gains likely would be minor, and many women would undergo unnecessary diagnostic procedures to assure that they are cancer free." They also point out that the difficulty of detecting ovarian cancer early persists for various reasons. "The biology of ovarian cancer, the arithmetic of screening, and the clinical characteristics of the disease and its treatment collude to make it difficult to find ovarian cancer early enough to matter."


'/>"/>
Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Predicting resistance to brain tumor chemotherapy
2. Tools for predicting diabetes exist but are not used, research shows
3. Mayo Clinic study: PSA test valuable in predicting biopsy need, low-risk prostate cancer
4. New research shows PET imaging effective in predicting lung cancer outcomes
5. FDG-PET appears promising for predicting prognosis of patients with inoperable NSCLC
6. Researchers investigate new mechanism for predicting how diseases spread
7. Predicting perilous plaque in coronary arteries via fluid dynamics
8. Predicting Who Will -- and Wont -- Survive a Heart Attack
9. Predicting premature birth possible through markers in mothers blood
10. Predicting serious drug side effects before they occur
11. Progress Reported in Predicting Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... Westside Dental Associates and ... since 1985. After thirty-two years, Dr. Latner has become one of the Los Angeles ... clients over the years with all their dental needs,” said Dr. Latner, who was ...
(Date:4/21/2017)... ... ... Each year, everyone is urged to give back to the earth on ... to a better future. However, supporting the environment should be an everyday practice. ... two to five times more polluted than outdoor air, reports the Environmental Protection Agency ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... familiar? These are five common elements between the Obamacare program that most ... control program which uses Warfarin poison to kill hogs. , Like Obamacare, ...
(Date:4/21/2017)... Indianapolis, Indiana (PRWEB) , ... April 21, 2017 ... ... statewide Network Service Provider, announces a significant bandwidth upgrade infrastructure service to Tele-Media ... to Tele-Media Solutions. One of IFN’s consortium member-owners, Tele-Media Solution’s protect transport ...
(Date:4/21/2017)... ... April 21, 2017 , ... MiracleFeet announced today ... years to help end the disability caused by untreated clubfoot in low-income countries. ... Global Clubfoot Initiative to end disability caused by clubfoot worldwide. , ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017  Zimmer Biomet Holdings, Inc. (NYSE ... today announced that it will be participating in the ... the InterContinental Hotel in Boston, Massachusetts ... present at 11:20 a.m. Eastern Time. A ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com .  ...
(Date:4/20/2017)... 20, 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... consumer product development program, based on its proprietary ... Investigative Dermatology (SID) 76 th Annual Meeting.  ... the sciences relevant to skin health and disease ...
(Date:4/20/2017)... , April 20, 2017  CVS Pharmacy, the ... unveiled a new store design to enhance the ... healthier food, health-focused products and expanded beauty selections ... help customers discover new offerings. Together with its ... evolution of the customer experience at CVS Pharmacy.  ...
Breaking Medicine Technology: