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Predicting ovarian cancer survival through tumor-attacking immune cells
Date:12/4/2013

SEATTLE One way to predict survival of many types of cancer is by counting the number of tumor-attacking immune cells that have migrated into the tumor in an effort to eradicate it a sign of the body's immune response to the cancer. However, quantifying these armies of immune cells has been difficult until now.

Scientists at Fred Hutchinson Cancer Research Center have developed a new method for counting a special class of cancer-fighting cells called tumor-infiltrating T lymphocytes, or TILs reliably, quickly and cheaply in patients with early stage and advanced ovarian cancer. They describe their findings online Dec. 4 in Science Translational Medicine.

Such technology, a DNA-amplification technique, has the potential to predict treatment response, cancer recurrence and disease-free survival earlier and more effectively than any current method, according to lead researcher and cancer geneticist Jason H. Bielas, Ph.D., an associate member of the Human Biology and Public Health Sciences divisions at Fred Hutch.

"Our experiments demonstrate an association between higher TIL counts and improved survival among women with ovarian cancer, and are consistent with prior observations that the immune response against ovarian cancer is a meaningful and independent prognostic factor," said Bielas, who was also the paper's corresponding and senior author.

"While variations in the measurement and characterization of TILs have limited their clinical utility as biomarkers of survival, our results highlight the significant translational potential of a robust, standardized, DNA-based assay to assess TILs in a variety of cancer types, including ovarian," he said.

Fred Hutch researchers developed the digital assay to count TILs, determine their frequency and develop a grouping system to determine their "clonality," a measure of the tumor's T-cell population.

In developing the test, Bielas and his team leveraged a technology co-created by first a
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Contact: Kristen Woodward
media@fredhutch.org
206-667-2210
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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