Navigation Links
Predicting ovarian cancer survival through tumor-attacking immune cells
Date:12/4/2013

SEATTLE One way to predict survival of many types of cancer is by counting the number of tumor-attacking immune cells that have migrated into the tumor in an effort to eradicate it a sign of the body's immune response to the cancer. However, quantifying these armies of immune cells has been difficult until now.

Scientists at Fred Hutchinson Cancer Research Center have developed a new method for counting a special class of cancer-fighting cells called tumor-infiltrating T lymphocytes, or TILs reliably, quickly and cheaply in patients with early stage and advanced ovarian cancer. They describe their findings online Dec. 4 in Science Translational Medicine.

Such technology, a DNA-amplification technique, has the potential to predict treatment response, cancer recurrence and disease-free survival earlier and more effectively than any current method, according to lead researcher and cancer geneticist Jason H. Bielas, Ph.D., an associate member of the Human Biology and Public Health Sciences divisions at Fred Hutch.

"Our experiments demonstrate an association between higher TIL counts and improved survival among women with ovarian cancer, and are consistent with prior observations that the immune response against ovarian cancer is a meaningful and independent prognostic factor," said Bielas, who was also the paper's corresponding and senior author.

"While variations in the measurement and characterization of TILs have limited their clinical utility as biomarkers of survival, our results highlight the significant translational potential of a robust, standardized, DNA-based assay to assess TILs in a variety of cancer types, including ovarian," he said.

Fred Hutch researchers developed the digital assay to count TILs, determine their frequency and develop a grouping system to determine their "clonality," a measure of the tumor's T-cell population.

In developing the test, Bielas and his team leveraged a technology co-created by first author Harlan S. Robins, Ph.D., a computational biologist and associate member of the Public Health Sciences and Human Biology divisions at Fred Hutch. They devised a way to easily screen T cells by capturing the genetic information of unique proteins these cells carry on their surface. Fred Hutch licensed the technology to Adaptive Biotechnologies, a company Robins co-founded.

In the present study, Robins, Bielas and colleagues tested this novel technique, called "QuanTILfy," on tumor samples from 30 ovarian cancer patients with known survival outcomes ranging from one to 22 months. They looked at the levels of TILs in their tumors and compared those levels to the women's survival. They found that higher TIL numbers correlated with better survival. For example, the percentage of TILs was approximately threefold higher on average for patients with a survival rate of more than five years as compared to patients with a survival rate of less than two years.

"Now that we have the sensitivity and ability to reproducibly count TILs in tumors, we may be able to stratify and more effectively treat patients based on tumor TIL count," Bielas said.


'/>"/>

Contact: Kristen Woodward
media@fredhutch.org
206-667-2210
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Study examines BI-RADS and MRI in predicting breast cancer
2. Predicting post-traumatic stress disorder before it happens
3. A new model for predicting recovery after spinal cord injury
4. Study uncovers simple way of predicting severe pain following breast cancer surgery
5. Researchers develop non-invasive technique for predicting patients response to chemotherapy
6. Predicting, preventing, and controlling pandemics: Making the case for a strategic action plan
7. Valuable tool for predicting pain genes in people
8. Combining diagnostic tests more accurate at predicting Alzheimers
9. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
10. Predicting hotspots for future flu outbreaks
11. Medtronic Infuse Bone Graft Lawsuits: Bernstein Liebhard LLP Notes New Report Predicting Hundreds of Medtronic Infuse Lawsuits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... Jonathan (Jon) Otterstatter to its board of directors. Otterstatter is co-founder, ... in the development of technological innovations that lead to broad-based healthcare solutions. , ...
(Date:5/24/2016)... ... 2016 , ... WaterAid launched the #perioddrama campaign to mark Menstrual Hygiene Day on ... around the world who do not have access to a toilet, even when they’re on ... dread of #perioddrama. The (sometimes hilarious) results help shine a light on the awkwardness that ...
(Date:5/24/2016)... Milwaukee, WI (PRWEB) , ... May 24, 2016 ... ... Facility In Milwaukee , Out patient Services To Begin In June , Aloria ... is pleased to announce the opening of Aloria Milwaukee, its first treatment facility ...
(Date:5/24/2016)... ... 2016 , ... Global Lyme Alliance (GLA), a leading nonprofit ... has named Scott Santarella as its new CEO. , Santarella is former ... San Francisco, where he successfully helped to grow the organization from a regional ...
(Date:5/24/2016)... ... May 24, 2016 , ... Dignity Health has announced ... The new facility is licensed under Dignity Health Arizona General Hospital, which opened ... Dignity Health in Arizona, said that the new facility will complement Dignity Health’s existing ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016   Purdue Pharma ... into an agreement with Egalet Corporation and Acura ... As part of the agreement the companies will ... enable all three companies to develop and sell ... "This agreement reflects the commitment of Purdue ...
(Date:5/20/2016)... 2016 According to the 2016 home ... demand for affordable healthcare solutions as since the early 2000s, ... In countries like the US, the healthcare cost rose faster ... consumer price index inflation rate stood at an average of ... to 3.62% during the same time period. This can be ...
(Date:5/19/2016)... 2016 According to a new market research ... (U.S., Germany , France , ... and Japan )", published by MarketsandMarkets, The market ... CAGR of 13.9% from 2016 to 2021.      (Logo: ... data Tables spread through 26 Pages and in-depth TOC on ...
Breaking Medicine Technology: